-
Peer-Reviewed Publication
March 11, 2021
Platform 1
In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy
W Xia, AR Kolli, K Koshibu, F Martin, A Kondylis, A Kuczaj, W Teck Tan, YS Yeo, G Tan, C Teng, K Woon , T Schneider, M Talikka, B Phillips, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1021/acs.jnatprod.0c01044
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Peer-Reviewed Publication
November 12, 2020
Platform 1
Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies
O Lavrynenko, B Titz, S Dijon, D Dos Santos , C Nury, T Schneider, E Guedj, J Szostak, A Kondylis, B Phillips, K Ekroos*, F Martin, M Peitsch, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1016/j.lfs.2020.118753
-
PublicationPeer-Reviewed Publication
January 1, 2021
Platform 1
An interlaboratory in vitro aerosol exposure system reference study
D Thorne*, J Adamson*, E Trelles-Sticken, R Wieczorek*, HP Behrsing *, S Steiner, S Majeed, S Frentzel, S Ishikawa*, S Ito*, L Simms *, K Yoshino*, J Hoeng, M Gaca*
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2F2397847321992752
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Peer-Reviewed Publication
February 19, 2021
Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass
J Lu*, N Chandrakanth*, RS Lewis, K Andres*, L Bovet, S Goepfert, RE Dewey*
* This author is not affiliated with PMI.DOI : 10.1038/s41598-021-83797-7
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Peer-Reviewed Publication
February 17, 2021
Heated Tobacco Products
Are heated tobacco products (HTPs) a public health opportunity?
G Baker, R Costanzo
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Peer-Reviewed Publication
February 7, 2021
Use of micro‐CT to determine tracheobronchial airway geometries in three strains of mice used in inhalation toxicology as disease models
M J Oldham*, F Lucci, C Foong, D Yeo, B Asgharian*, S. Cockram*, S. Luke*, J Chua, M Peitsch, A Kuczaj
* This author is not affiliated with PMI.The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
DOI : 10.1002/ar.24596
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Peer-Reviewed Publication
January 18, 2021
Platform 1
Effect of Switching to the Tobacco Heating System Versus Continued Cigarette Smoking on Chronic Generalized Periodontitis Treatment Outcome: Protocol for a Randomized Controlled Multicenter Study
S Pouly, W Teck Ng, M Benzimra, A Soulan, N Blanc, F Zanetti, P Picavet, G Baker, C Haziza
DOI : https://doi.org/10.2196/15350
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Book Chapter
January 18, 2021
Toxicological Evaluation of Electronic Nicotine Delivery Products
F Zanetti, W Xia, E T Wong, P Vanscheeuwijck, M Van der Toorn, B Titz, M Talikka, J Szostak, M Smith, D Smart, D Sciuscio, W Schlage, JP Schaller, R Savioz*, P Pratte, C Poussin, S Pouly, P Picavet, B Phillips, M Peck, M Mitova, D McHugh, A May*, C Mathis, F Martin, D Marescotti, S Maeder, K Luettich, F Lucci, A Kuczaj, AR Kolli, U Kogel, NV Ivanov, A Iskandar, C Haziza, C Goujon-Ginglinger, S Frentzel, M Firestone , MA Choukrallah, D Bovard, S Boue, M Bentley, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Presentation
November 21, 2020
Platform 1
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit
G Plebani
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Presentation
December 9, 2020
Platform 3
Comparative Assessment of Pharmacokinetics and Acute Lung Inflammation of Nicotine Dry Powder Aerosols Generated by PreciseInhale®
S Lam, R Ng, B Phillips, W Teck Tan, C Teng, C Wong, R Piault, C Merg, D Sciuscio, J Hoeng, P Vanscheeuwijck
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Presentation
December 10, 2020
Use of qualitative research to ensure we measure what matters to users of tobacco and nicotine products
E. F. Afolalu, E Clerc, L Abetz-Webb*, C Chrea
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 29, 2020
Platform 3
State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products
S Boue, D Goedertier, J Hoeng, A Iskandar, A Kuczaj, D Marescotti, C Mathis, A May*, B Phillips, M Peitsch, W Schlage, D Sciuscio, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847320979751
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Peer-Reviewed Publication
November 18, 2020
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures
A Giralt, A Iskandar, F Martin, E Moschini*, T Serchi*, A Kondylis, D Marescotti, P Leroy, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, AC Gutleb*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.toxlet.2020.11.006
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Peer-Reviewed Publication
November 28, 2020
Multispecies aerosol evolution and deposition in a human respiratory tract cast model
M Asgari, F Lucci, A Kuczaj
DOI : 10.1016/j.jaerosci.2020.105720
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Publication
November 5, 2020
Platform 2
Reduced levels of biomarkers of exposure in smokers switching to the Carbon-Heated Tobacco Product 1.0: a controlled, randomized, open-label 5-day exposure trial
CT Tran, M Bosilkovska, G de La Bourdonnaye, N Blanc, C Haziza
DOI : 10.1038/s41598-020-76222-y
-
PublicationPeer-Reviewed Publication
November 1, 2020
Tobacco harm reduction: The potential to reduce the risk from smoking: a six-month exposure response study on switching from cigarettes to tobacco heating system (THS)
C Haziza, R Costanzo, G de La Bourdonnaye
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Peer-Reviewed Publication
October 29, 2020
Heated Tobacco Products
Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity
A van der Plas, S Pouly, N Blanc, C Haziza, G de La Bourdonnaye, B Titz, J Hoeng, NV Ivanov, BV Taranu, A Heremans
DOI : 10.1016/j.toxrep.2020.10.017
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Peer-Reviewed Publication
October 12, 2020
Analysis of waterpipe aerosol constituents in accordance with the ISO standard 22486
G Jaccard, D Tafin Djoko, A Korneliou, M Belushkin
DOI : 10.1016/j.toxrep.2020.10.007
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Poster
September 21, 2020
Lung/liver-on-a-chip for systemic toxicity studies
D Bovard, A Sandoz, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng
-
Poster
October 4, 2020
Heated Tobacco Products
Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater
-
Poster
October 28, 2020
Development and testing of the Independent Holistic Air-Liquid Aerosol Exposure System (InHALES)
-
Poster
October 19, 2020
Nicotine-Containing E-Vapor Products
Plasma Protein Biomarker Identification for Monitoring Molecular Changes in Smokers, Former Smokers, and E-Vapor Product Users Compared with Never Smokers
C Nury, Y Eb-Levadoux, AR Kolli, C Poussin, TM Curran*, LA Baglia*, RA Berg*, Loyse Felber Medlin , S Ansari, E Kishazi, F Martin, B Titz, P Picavet, NV Ivanov, SL Spinelli*, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 15, 2020
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
U Marx*, T. Akabane *, TB Andersson *, E. Baker *, M Beilmann*, S Beken*, S. Brendler-Schwaab*, M Cirit*, R. David *, E-M Dehne*, I. Durieux *, L. Ewart *, SC Fitzpatrick*, O Frey*, F Fuchs *, L Griffith *, G Hamilton *, T Hartung*, J Hoeng, H Hogberg *, DJ Hughes *, DE Ingber *, A Iskandar, T Kanamori *, H Kojima*, J Kuehnl*, M Leist*, B Li *, P Loskill *, DL Mendrick *, T Neumann *, G Pallocca *, I Rusyn *, L Smirnova*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, S Tsyb*, M Trapecar*, BVD Water *, JVD Eijnden-van Raaij*, P Vulto*, K Watanabe*, A Wolf*, X Zhou*, A Roth*
* This author is not affiliated with PMI.DOI : 10.14573/altex.2001241
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Peer-Reviewed Publication
September 25, 2020
Heated Tobacco Products
Robustness of HPHC Reduction for THS 2.2 Aerosol Compared with 3R4F Reference Cigarette Smoke Under High Intensity Puffing Conditions
C Goujon-Ginglinger, S Kleinhans, S Maeder, L Poget, JP Schaller
Beiträge zur Tabakforschung International/Contributions to Tobacco Research
DOI : 10.2478/cttr-2020-0008
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Peer-Reviewed Publication
October 6, 2020
Heated Tobacco Products
Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke
G Rodrigo, G Jaccard, D Tafin Djoko, A Korneliou, M Esposito, M Belushkin
DOI : 10.1007/s00204-020-02924-x
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Peer-Reviewed Publication
October 4, 2020
Nicotine-Containing E-Vapor Products
Collecting e-cigarette aerosols for in vitro applications: A survey of the biomedical literature and opportunities to increase the value of submerged cell culture-based assessments
D Smart, G Phillips*
* This author is not affiliated with PMI.DOI : 10.1002/jat.4064
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Poster
September 7, 2020
Heated Tobacco Products
Dos and don’ts in the design of indoor air quality studies on smoke-free products
C Goujon-Ginglinger, M Mitova, M Rotach, J.H Kim, S Maeder
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Poster
September 17, 2020
Heated Tobacco Products
Compilation of in vitro studies evaluating the impact of exposure to aerosols from heated tobacco products and an electronic vapor device on oral health and dental esthetics.
F Zanetti, A Nussbaum, A Iskandar, X Zhao, Y Ren*, S Majeed, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 12, 2020
Heated Tobacco Products
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.004
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Peer-Reviewed Publication
September 12, 2020
A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products
A Sewer, F Zanetti, A Iskandar, E Guedj, R Dulize, D Peric, D Bornand, C Mathis, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.001
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Poster
September 7, 2020
Heated Tobacco Products
Human chemical signature — Investigating the influence of human presence and selected activities on concentrations of airborne constituents
C Goujon-Ginglinger, M Mitova, M Rotach, J.H Kim, S Maeder
-
Peer-Reviewed Publication
September 4, 2020
Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors
D Bovard, A Giralt, K Trivedi, L Neau, Petros Kanellos , A Iskandar, A Kondylis, K Luettich, S Frentzel, J Hoeng, M Peitsch
Current Research in Toxiocology
DOI : 10.1016/j.crtox.2020.08.002
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Poster
August 20, 2019
Heated Tobacco Products
Assessment of the impact of human presence and daily activities on Indoor air quality
M Rotach, M Tharin, N Bielik
-
Peer-Reviewed Publication
August 24, 2020
Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
P A Ruiz Castro, U Kogel, G Lo Sasso, B Phillips, A Sewer, B Titz, L Garcia, A Kondylis, E Guedj, D Peric, D Bornand, R Dulize, C Merg, M Corciulo, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1186/s12950-020-00260-6
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Peer-Reviewed Publication
August 7, 2020
Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients
G Lo Sasso, L Khachatryan, A Kondylis, JND Battey, N Sierro, NA Danilova*, TV Grigoryeva*, MI Markelova*, DR Khusnutdinova*, AV Laikov*, II Salafutdinov*, YD Romanova*, MN Siniagina*, IY Vasiliev*, EA Boulygina*, VV Solovyeva*, EE Garanina*, KV Kitaeva*, KY Ivanov*, DS Chulpanova*, KS Kletenkov*, AR Valeeva*, A Kh Odintsova*, MD Ardatskaya*, RA Abdulkhakov*, NV Ivanov, M Peitsch, J Hoeng, SR Abdulkhakov*
* This author is not affiliated with PMI.DOI : 10.1093/ibd/izaa188
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice
B Titz, A Sewer, K Luettich, E T Wong, E Guedj, C Nury, T Schneider, Y Xiang, K Trivedi, G Vuillaume, P Leroy, A Buettner*, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa132
-
Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke
E T Wong, K Luettich, S Krishnan, S K Wong, WT Lim, D Yeo, A Buettner*, P Leroy, G Vuillaume, S Boue, J Hoeng, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa131
-
Peer-Reviewed Publication
August 20, 2020
Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor
A Susz, P Pratte, C Goujon-Ginglinger
Aerosol and Air Quality Research
DOI : 10.4209/aaqr.2019.11.0604
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Poster
July 12, 2020
Heated Tobacco Products
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch
-
Peer-Reviewed Publication
July 14, 2020
Metabolic networks of the Nicotiana genus in the spotlight: content, progress and outlook
H Foerster*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI.DOI : 10.1093/bib/bbaa136
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Presentation
July 7, 2020
The sbvIMPROVER Metagenomics Diagnostics for Inflammatory Bowel Disease Challenge: Results and lessons learned
L Khachatryan
-
Peer-Reviewed Publication
July 8, 2020
Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish
R Li*, A. Zupanic*, M Talikka, V Belcastro, S Madan*, J. Dörpinghaus*, C. vom Berg*, J Szostak, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.0c00095
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Presentation
July 1, 2020
Heated Tobacco Products
Tobacco Heating System in mild to moderate chronic obstructive pulmonary disease subjects: An exploratory analysis
F Sergio
-
Presentation
July 1, 2020
Heated Tobacco Products
Effects of cigarette smoking tobacco heating system use and smoking cessation on cough
F Sergio
-
Poster
December 10, 2019
3D human microvessel-on-a-chip model for studying monocyte-endothelial adhesion under flow - application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI. -
Poster
June 1, 2020
Monitoring of exogenous compound kinetics in exhaled breath
T Zikovic Semren, C Laszlo, M Gomez*, G Vidal-de-Miguel*, J Hoeng, M Peitsch, NV Ivanov, P A. Guy*
* This author is not affiliated with PMI. -
Poster
March 3, 2020
Nicotine-Containing E-Vapor Products
A structure-based grouping approach for evaluating the toxicity of e-cigarette flavor ingredients: A 5-week inhalation study in A/J mice
D Sciuscio, K Ashutosh*, P Leroy, A Nussbaum, K M Lee*, E T Wong, P Vanscheeuwijck, M Peitsch, K Luettich, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 17, 2020
Heated Tobacco Products
Workshop Series to Identify, Discuss, and Develop Recommendations for the Optimal Generation and Use of In Vitro Assay Data for Tobacco Product Evaluation: Phase 1 Genotoxicity Assays
M M Moore*, J Clements*, P Desai*, U Doshi*, M Gaca*, X Guo*, T Hashizume*, K G Jordan*, K M Lee*, R Leverette*, D McHugh, J Miller-Holt*, G Phillips*, H Raabe*, L Recio*, S Roy*, D Smart, L F Stankowski, Jr.*, D Thorne*, E Weber*, R Wieczorek*, K Yoshino*, R Curren*
* This author is not affiliated with PMI.DOI : 10.1089/aivt.2020.0004
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Peer-Reviewed Publication
June 24, 2020
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes
L Gijzen*, D Marescotti, E Raineri*, A Nicolas*, HL Lanz*, D Guerrera*, R van Vught*, J Joore*, P Vulto*, M Peitsch, J Hoeng, G Lo Sasso, D Kurek*
* This author is not affiliated with PMI.DOI : 10.1177/2472630320924999
-
Peer-Reviewed Publication
June 4, 2020
Heated Tobacco Products
Estimating the population health impact of recently introduced modified risk tobacco products: a comparison of different approaches
PN Lee*, D Abrams*, A Bachand*, G Baker, R Black*, O Camacho*, G Curtin*, S Djurdjevic, A Hill*, D Mendez*, R S Muhammad-Kah*, J L Murillo*, R Niaura*, YB Pithawalla*, B Poland*, S Sulsky*, L Wei*, R Weitkunat
* This author is not affiliated with PMI.DOI : 10.1093/ntr/ntaa102
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Peer-Reviewed Publication
June 8, 2020
Alkaloid chemophenetics and transcriptomics of the Nicotiana genus
K P. Kaminski, L Bovet, H Laparra, G Lang, D De Palo, N Sierro, S Goepfert, NV Ivanov
DOI : 10.1016/j.phytochem.2020.112424
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Peer-Reviewed Publication
June 10, 2020
Heated Tobacco Products
Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC–MS deconvolution procedures
A Haiduc, F Zanetti, X Zhao, W Schlage, M Scherer*, N Pluym*, P Schlenger*, NV Ivanov, S Majeed, J Hoeng, M Peitsch, Y Ren*, P A. Guy*
* This author is not affiliated with PMI.DOI : 10.1016/j.jchromb.2020.122228
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Peer-Reviewed Publication
April 27, 2020
Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence
A Isaev*, A Drobiazko*, N Sierro, J Gordeeva*, I Yosef*, U Qimron*, NV Ivanov, K Severinov*
* This author is not affiliated with PMI.DOI : 10.1093/nar/gkaa290
-
Peer-Reviewed Publication
June 5, 2020
Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES)
S Steiner, P Herve, C Pak, S Majeed, A Sandoz, A Kuczaj, J Hoeng
DOI : 10.1016/j.tiv.2020.104909
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Peer-Reviewed Publication
May 14, 2020
Nicotine-Containing E-Vapor Products
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model
MK Reumann*, J Schaefer*, B Titz, RH Aspera-Werz*, E T Wong, J Szostak, V Häussling*, S Ehnert*, P Leroy, W Teck Tan, A Kuczaj, C Audretsch*, F Springer*, A Badke*, P Augat*, L Quentanilla-Fend*, M Martella*, K M Lee*, M Peitsch, J Hoeng, AK Nussler*
* This author is not affiliated with PMI.DOI : 10.1007/s00204-020-02769-4
-
Peer-Reviewed Publication
May 13, 2020
Nicotine-Containing E-Vapor Products
Tracing the composition of single e-cigarette aerosol droplets in situ by laser-trapping and Raman scattering
G David*, E A Parmentier*, I Taurino, R Signorell*
* This author is not affiliated with PMI.DOI : 10.1038/s41598-020-64886-5
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Peer-Reviewed Publication
May 12, 2020
Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies
K Schimek*, S Frentzel, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, H Erfurth*, E-M Dehne*, A Winter*, U Marx*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1038/s41598-020-64219-6
-
Peer-Reviewed Publication
May 11, 2020
Platform 1
Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2
J Walczak*, D Malińska*, K Drabik*, B Michalska*, M Prill*, S Johne, K Luettich, J Szymanski*, M Peitsch, J Hoeng, J Duszynski*, M Wieckowski*, M Van der Toorn, J Szczepanowska*
* This author is not affiliated with PMI.Cellular Physiology and Biochemistry
DOI : DOI.ORG/10.33594/000000216
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Peer-Reviewed Publication
May 6, 2020
Heated Tobacco Products
Exposure to harmful and potentially harmful constituents decreased in smokers switching to Carbon-Heated Tobacco Product
M Bosilkovska, CT Tran, G de La Bourdonnaye, BV Taranu, M Benzimra, C Haziza
DOI : 10.1016/j.toxlet.2020.04.013
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Peer-Reviewed Publication
May 5, 2020
Nicotine-Containing E-Vapor Products
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J Ho, D Sciuscio, U Kogel, B Titz, P Leroy, G Vuillaume, M Talikka, E Martin, P Pospisil, S Lebrun, W Xia, T Lee, Y X Chng, B Phillips, E Veljkovic, E Guedj, Y Xiang, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
DOI : 10.1007/s00204-020-02759-6
-
Peer-Reviewed Publication
April 25, 2020
Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective
K Ekroos*, O Lavrynenko, B Titz, C Pater, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1016/j.plipres.2020.101030
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Peer-Reviewed Publication
April 21, 2020
Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system
M J Oldham*, ND Castro*, J Zhang*, F Lucci, P Kosachevsky*, AA Rostami*, I G Gilman*, YB Pithawalla*, A Kuczaj, J Hoeng, K M Lee*
* This author is not affiliated with PMI.DOI : 10.1016/j.tiv.2020.104870
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Peer-Reviewed Publication
April 25, 2020
Heated Tobacco Products
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng
Computational and Structural Biotechnology Journal
DOI : 10.1016/j.csbj.2020.04.011
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Peer-Reviewed Publication
February 18, 2020
Heated Tobacco Products
Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening
M Bentley, M Almstetter, D Arndt, A Knorr, E Martin, P Pospisil, S Maeder
Analytical and Bioanalytical Chemistry
DOI : 10.1007/s00216-020-02502-1
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Peer-Reviewed Publication
February 18, 2020
Alternatives to Animal Use in Risk Assessment of Mixtures
AW Hayes, A Muriana*, A Alzualde*, DB Fernandez*, A Iskandar, M Peitsch, A Kuczaj, J Hoeng
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581820905088
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Peer-Reviewed Publication
February 13, 2020
Anthropometry-based generation of personalized and population-specific human airway models
R Kannan*, ZJ Chen*, A Przekwas*, P Segars*, F Martin, A Kuczaj, J Hoeng
* This author is not affiliated with PMI.International Journal for Numerical Methods in Biomedical Engineering
DOI : 10.1002/cnm.3324
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
January 23, 2020
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures
D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng
SLAS TECHNOLOGY: Translating Life Sciences Innovation
DOI : 10.1177/2472630319895473
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Peer-Reviewed Publication
January 21, 2020
Platform 1
State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products
S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847319897869
-
Peer-Reviewed Publication
September 3, 2019
A complex matrix characterization approach, applied to cigarette smoke, that integrates multiple analytical methods and compound identification strategies for non‐targeted liquid chromatography with high‐resolution mass spectrometry
D Arndt, C Wachsmuth, C Buchholz, M Bentley
Rapid Communications in Mass Spectrometry
DOI : doi.org/10.1002/rcm.8571
-
Peer-Reviewed Publication
January 7, 2020
Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of in Vitro Aerosol Exposure Experiments
C Frege, M Asgari, S Steiner, S Ferreira, S Majeed, F Lucci, S Frentzel, J Hoeng, A Kuczaj
Chemical Research in Toxicology
DOI : doi.org/10.1021/acs.chemrestox.9b00381
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Peer-Reviewed Publication
December 27, 2019
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro
D Smart, FR Helbling, M Verardo, A Huber, D McHugh, P Vanscheeuwijck
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI : 10.1016/j.mrgentox.2019.503129
-
Peer-Reviewed Publication
January 6, 2020
Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond
Critical Reviews in Toxicology
DOI : 10.1080/10408444.2019.1692780
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Peer-Reviewed Publication
December 21, 2019
Applying Systems Toxicology Methods to Drug Safety
M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch
DOI : 10.1016/B978-0-12-801238-3.11522-3
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Peer-Reviewed Publication
December 19, 2019
An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
O Alijevic, D McHugh, L Rufener*, A Mazurov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1016/j.phytochem.2019.112187
-
Presentation
December 10, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
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Peer-Reviewed Publication
December 20, 2019
Nicotine-Containing E-Vapor Products
Selected Harmful and Potentially Harmful Constituents Levels in Commercial e-Cigarettes
M Belushkin, D Tafin Djoko, M Esposito, A Korneliou, C Jeannet, M Lazzerini, G Jaccard
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.9b00470
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Peer-Reviewed Publication
November 29, 2019
Addressing traceability in social measurement: establishing a common metric for dependence
T Salzberger, S Cano, L Abetz-Webb*, E Afolalu, C Chrea, R Weitkunat, K Fagerström*, Jed E Rose PhD*
* This author is not affiliated with PMI.Journal of Physics: Conference Series
DOI : 10.1088/1742-6596/1379/1/012024
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Peer-Reviewed Publication
November 22, 2019
Experimental and computational investigation of a nose-only exposure chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1687843
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Peer-Reviewed Publication
December 1, 2019
Nicotine-Containing E-Vapor Products
Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay
D Smart, FR Helbling, D McHugh, P Vanscheeuwijck
Toxicology Research and Application
DOI : 10.1177/2397847319887904
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Peer-Reviewed Publication
December 4, 2019
Platform 1
An experimental investigation into the operation of an electrically heated tobacco system
V Cozzani*, F. *, T McGrath, M. Mahler, M Nordlund, M Smith, JP Schaller, G Zuber
* This author is not affiliated with PMI.DOI : 10.1016/j.tca.2019.178475
-
Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
-
Book Chapter
November 15, 2019
How to build your multiorgan-on-a-chip system: a case study
DOI : 10.1016/B978-0-12-817202-5.00015-2
-
Peer-Reviewed Publication
November 13, 2019
Heated Tobacco Products
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
M Van der Toorn, K Koshibu, W Schlage, S Majeed, P Pospisil, J Hoeng, M Peitsch
DOI : 10.1016/j.toxrep.2019.11.008
-
Peer-Reviewed Publication
November 15, 2019
Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration
European Journal of Pharmacology
DOI : 10.1016/j.ejphar.2019.172809
-
Peer-Reviewed Publication
November 11, 2019
Asparagine Synthesis During Tobacco Leaf Curing
L Bovet, C Cheval, A Hilfiker, JND Battey, D Langlet, Hervé Broye, J D Schwaar, P Ozelley, G Lang, N Bakaher, H Laparra, S Goepfert
DOI : 10.3390/plants8110492
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Peer-Reviewed Publication
November 6, 2019
Human chemical signature: Investigation on the influence of human presence and selected activities on concentrations of airborne constituents
M Mitova, C Cluse, C Goujon-Ginglinger, S Kleinhans, M Rotach, M Tharin
DOI : 10.1016/j.envpol.2019.113518
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
September 30, 2019
Using data on snus use in Sweden to compare different modelling approaches to estimate the population health impact of introducing a smoke-free tobacco product
S Djurdjevic, L Pecze*, R Weitkunat, F Lüdicke, JS Fry*, PN Lee*
* This author is not affiliated with PMI.DOI : 10.21203/rs.2.10935/v3
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Peer-Reviewed Publication
October 10, 2019
Deposition Efficiency and Uniformity of Monodisperse Solid Particle Deposition in the Vitrocell® 24/48 Air-Liquid-Interface in-vitro Exposure System
M J Oldham*, ND Castro*, J Zhang*, AA Rostami*, F Lucci, YB Pithawalla*, A Kuczaj, I G Gilman*, P Kosachevsky*, J Hoeng, K M Lee*
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1676877
-
Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Peer-Reviewed Publication
February 24, 2019
Heated Tobacco Products
Potential predictors of adoption of the Tobacco Heating System by U.S. adult smokers: An actual use study [version 1; peer review: 1 approved, 2 approved with reservations]
S Roulet, C Chrea, Claudia Kanitscheider*, G Kallischnigg, PP Magnani, R Weitkunat
* This author is not affiliated with PMI.DOI : 10.12688/f1000research.17606.1
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Peer-Reviewed Publication
September 10, 2019
Nicotine-Containing E-Vapor Products
Lysosomotropic-related limitations of the BALB/c 3T3 cell-based neutral red uptake assay and an alternative testing approach for assessing e-liquid cytotoxicity
G Cudazzo, D Smart, D McHugh, P Vanscheeuwijck
DOI : 10.1016/j.tiv.2019.104647
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Peer-Reviewed Publication
September 9, 2019
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles
DOI : 10.1080/08958378.2019.1662526
-
Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
-
Peer-Reviewed Publication
September 3, 2019
NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
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Peer-Reviewed Publication
August 17, 2019
Platform 4
Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations
X Zhao, F Zanetti, L Wang*, J Pan*, S Majeed, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.DOI : 10.1016/j.jdent.2019.103182
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Poster
August 26, 2019
Multispecies aerosol evolution and deposition in the Human Respiratory Tract
M Asgari, F Lucci, A Kuczaj
-
Poster
August 27, 2019
Evaluation of a small whole-body exposure chamber for mice
W Teck Tan, S Krishnan, B Phillips, A Kuczaj, J Hoeng, P Vanscheeuwijck
-
Poster
August 19, 2019
Evaluation of selected portable solutions for the assessment of indoor air quality
E G R Rouget, C Medan, M Tharin, A Glabasnia, M Mitova, C Goujon-Ginglinger
-
Poster
May 21, 2019
Heated Tobacco Products
Modeling the Population Years of Life Saved in Japan, Italy, Singapore, And in The U.S. by Introducing a Reduced-Risk Product
S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva
-
PublicationPeer-Reviewed Publication
June 23, 2019
Performance Evaluation of a Nontargeted Platform Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Integrating Computer-Assisted Structure Identification and Automated Semiquantification for the Comprehensive Chemical Characterization of a Complex Matrix
A Knorr, M Almstetter, E Martin, A Castellon, P Pospisil, M Bentley
DOI : acs.analchem.9b01659
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Poster
July 7, 2019
Downregulation of a putative nitrate transporter (CLC-Nt2) substantially reduces the accumulation of tobacco-specific nitrosamines in air-cured tobaccos
A Hilfiker, L Bovet, J Lu*, P Campanoni, H Laparra, J D Schwaar, RS Lewis, RE Dewey*, S Goepfert
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 3, 2019
Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
S Schorderet Weber, K P. Kaminski, JL Perret*, P Leroy, A Mazurov, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.110660
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Peer-Reviewed Publication
July 11, 2019
Mode‐of‐action analysis of the effects induced by nicotine in the in vitro micronucleus assay
D Smart, FR Helbling, M Verardo, D McHugh, P Vanscheeuwijck
Environmental and Molecular Mutagenesis
DOI : 10.1002/em.22314
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Peer-Reviewed Publication
March 1, 2017
Impairing both HMA4 homeologs is required for cadmium reduction in tobacco
V Liedschulte, H Laparra, JND Battey, J D Schwaar, Hervé Broye, R Mark, M Klein, S Goepfert, L Bovet
DOI : 10.1111/pce.12870
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Peer-Reviewed Publication
June 1, 2017
Genomic insights into the evolution of the nicotine biosynthesis pathway in tobacco
M Kajikawa*, N Sierro, H Kawaguchi*, N Bakaher, NV Ivanov, T Hashimoto*, T Shoji*
* This author is not affiliated with PMI.DOI : 10.1104/pp.17.00070
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Peer-Reviewed Publication
July 14, 2017
A model for evolution and regulation of nicotine biosynthesis regulon in tobacco
M Kajikawa*, N Sierro, T Hashimoto*, T Shoji*
* This author is not affiliated with PMI.DOI : 10.1080/15592324.2017.1338225
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Peer-Reviewed Publication
July 27, 2017
Multiple disease resistance loci affect soil-borne disease resistance in tobacco (Nicotiana tabacum L.)
K Drake-Stowe*, N Bakaher, S Goepfert, B Philippon, R Mark, P Peterson*, RS Lewis
* This author is not affiliated with PMI.DOI : 10.1094/PHYTO-03-17-0118-R
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Peer-Reviewed Publication
November 17, 2016
Structured plant metabolomics for the simultaneous exploration of multiple factors
N Vasilev*, J Boccard*, G Lang, U Grömping*, R Fischer*, S Goepfert, S Rudaz*, S Schillberg*
* This author is not affiliated with PMI.DOI : 10.1038/srep37390
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Peer-Reviewed Publication
January 23, 2016
Expression of a constitutively active nitrate reductase variant in tobacco reduces tobacco-specific nitrosamine accumulation in cured leaves and cigarette smoke
J Lu*, L Zhang*, RS Lewis, L Bovet, S Goepfert, A M Jack*, J D Crutchfield*, H Ji*, RE Dewey*
* This author is not affiliated with PMI.DOI : 10.1111/pbi.12510
-
Peer-Reviewed Publication
November 1, 2016
Identification of CYP82E21 as a functional nicotine N-demethylase in tobacco flowers
V Liedschulte, J D Schwaar, H Laparra, A Vuarnoz, B Philippon, N Bakaher, N Sierro, L Bovet, G Lang, S Goepfert
DOI : 10.1016/j.phytochem.2016.08.004
-
Peer-Reviewed Publication
December 19, 2014
Matrix-bound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in tobacco: Quantification and evidence for an origin from lignin-incorporated alkaloids
G Lang, A Vuarnoz
DOI : 10.1021/np500725a
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Publication
January 1, 2013
Advances in Nicotiana Genetic and “Omics” Resources
JND Battey, N Sierro, N Bakaher, NV Ivanov
Genomics of Plant Genetic Resources Volume 1. Managing, sequencing and mining genetic resources
pp 511-532
DOI : 10.1007/978-94-007-7572-5
-
Peer-Reviewed Publication
May 15, 2013
Whole genome profiling physical map and ancestral annotation of tobacco Hicks Broadleaf
N Sierro, J van Oeveren*, M J T van Eijk*, F Martin, K Stormo*, M Peitsch, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1111/tpj.12247
-
Peer-Reviewed Publication
August 6, 2013
Controlled vocabularies for plant anatomical parts optimized for use in data analysis tools and for cross-species studies
R Meskauskiene*, O Laule*, NV Ivanov, F Martin, M Wyss*, W Gruissem*, Philip Zimmermann*
* This author is not affiliated with PMI.DOI : 10.1186/1746-4811-9-33
-
Peer-Reviewed Publication
June 1, 2012
Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes
Christophe Sallaud*, Cécile Giacalone*, Romy Töpfer, S Goepfert, N Bakaher, Sandrine Rösti, Alain Tissier*
* This author is not affiliated with PMI.DOI : 10.1111/j.1365-313X.2012.05068.x
-
Peer-Reviewed Publication
November 28, 2012
Design of a tobacco exon array with application to investigate the differential cadmium accumulation property in two tobacco varieties
F Martin, L Bovet, A Cordier, M Stanke, I Gunduz, M Peitsch, NV Ivanov
DOI : 10.1186/1471-2164-13-674
-
Peer-Reviewed Publication
March 21, 2012
Molecular diversity, population structure, and linkage disequilibrium in a worldwide collection of tobacco (Nicotiana tabacum L.) germplasm
Agostino Fricano*, N Bakaher, Marcello Del Corvo*, Pietro Piffanelli*, P Donini, Alessandra Stella*, NV Ivanov, Carlo Pozzi
* This author is not affiliated with PMI.DOI : 10.1186/1471-2156-13-18
-
Peer-Reviewed Publication
July 1, 2011
A high density genetic map of tobacco (Nicotiana tabacum L.) obtained from large scale microsatellite marker development
G Bindler, Jörg Plieske*, N Bakaher, I Gunduz, NV Ivanov, R Van Der Hoeven, Martin Ganal*, P Donini
* This author is not affiliated with PMI.Theoretical and Applied Genetics
DOI : 10.1007/s00122-011-1578-8
-
Peer-Reviewed Publication
February 1, 2010
COSII genetic maps of two diploid Nicotiana species provide a detailed picture of synteny with tomato and insights into chromosome evolution in tetraploid N. tabacum
Feinan Wu*, Nancy T. Eannetta*, Yimin Xu*, Jörg Plieske*, Martin Ganal*, Carlo Pozzi, N Bakaher, Steven D. Tanksley*
* This author is not affiliated with PMI.Theoretical and Applied Genetics
DOI : 10.1007/s00122-009-1206-z
-
PublicationPeer-Reviewed Publication
May 24, 2019
Heated Tobacco Products
Favorable Changes in Biomarkers of Potential Harm to Reduce the Adverse Health Effects of Smoking in Smokers Switching to the Menthol Tobacco Heating System 2.2 for Three Months (Part 2)
C Haziza, G de La Bourdonnaye, A Donelli, D Skiada, V Poux, R Weitkunat, G Baker, P Picavet, F Lüdicke
DOI : 10.1093/ntr/ntx028
-
PublicationPeer-Reviewed Publication
July 3, 2019
Heated Tobacco Products
Effects of switching to a heat-not-burn tobacco product on biologically-relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial
F Lüdicke, M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, M Peitsch, R Weitkunat
Cancer Epidemiology, Biomarkers & Prevention
DOI : 10.1158/1055-9965.EPI-18-0915
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InfoposterPoster
July 2, 2019
A lung-on-a-chip platform for improved tissue maturation
D Bovard, A Sandoz, M Morelli, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng
-
PublicationPeer-Reviewed Publication
June 22, 2019
Systems toxicology approach to unravel early indicators of squamous cell carcinoma rate in rat nasal epithelium induced by formaldehyde exposure
International Conference on Practical Applications of Computational Biology & Bioinformatics
DOI : 10.1007/978-3-030-23873-5_3
-
Poster
June 24, 2019
Prediction models of retention indices: application to gas chromatography coupled to high-resolution mass spectrometry for two column types: DB-624 and HP-5ms
A G Haiduc, E Dossin, P Diana, P Guy, NV Ivanov, M Peitsch
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Poster
June 24, 2019
Untargeted Metabolomics Application to Monitor Urine Samples by Ultra-High-Pressure Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
C Laszlo, A G Haiduc, M. Fatarova, E Dossin, F. de Jong*, C. Beecher*, A. Kamleh*, P Guy, NV Ivanov, M Peitsch
* This author is not affiliated with PMI. -
PublicationPeer-Reviewed Publication
June 10, 2019
Development of a realistic human respiratory tract cast representing physiological thermal conditions
M Asgari, F Lucci, J Bialek, B Dunan*, G Andreatta*, R Smajda*, S Lani*, N Blondiaux*, S Majeed, S Steiner, JP Schaller, S Frentzel, J Hoeng, A Kuczaj
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1612839
-
PublicationPeer-Reviewed Publication
June 13, 2019
Mitochondria as a possible target for nicotine action
D Malińska*, M Wieckowski*, B Michalska*, K Drabik*, M Prill*, P Patalas-Krawczyk*, J Walczak*, J Szymanski*, C Mathis, M Van der Toorn, K Luettich, J Hoeng, M Peitsch, J Duszynski*, J Szczepanowska*
* This author is not affiliated with PMI.Journal of Bioenergetics and Biomembranes
DOI : 10.1007/s10863-019-09800-z
-
Peer-Reviewed Publication
June 7, 2019
Heated Tobacco Products
Biological and functional changes in healthy adult smokers who are continuously abstinent from smoking for one year: Protocol for a prospective, observational, multicenter cohort study
CT Tran, Loyse Felber Medlin , N Lama, BV Taranu, W Teck Ng, C Haziza, P Picavet, G Baker, F Lüdicke
DOI : 10.2196/12138
-
PublicationPeer-Reviewed PublicationMethods and Protocols
June 12, 2019
Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems
C Mathon, D Bovard, Q Dutertre, S Sendyk, M Bentley, J Hoeng, A Knorr
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Poster
June 14, 2019
Platform 1
Tobacco product use after the launch of a heat-not-burn alternative in Japan: results of two cross-sectional surveys
P Langer, L Prieto, C. Rousseau, A. Formey, D Skiada, E. F. Afolalu, Z Sponsiello Wang, K. Fischer, G Baker, R Weitkunat
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Poster
June 14, 2019
Population Health Impact Model Web Application
-
PublicationPoster
June 14, 2019
One year of continuous smoking abstinence: a study on biological and functional changes in healthy adult smokers
Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke
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Poster
May 22, 2019
The development of a new measurement instrument to assess health and functioning among tobacco and nicotine product users: the preparatory phase
E Spies, A Bacso, E Afolalu, L Abetz-Webb*, S Gallot, V Law*, D Floyd*, R Weitkunat, C Chrea
* This author is not affiliated with PMI. -
PublicationPeer-Reviewed Publication
March 26, 2019
Heated Tobacco Products
A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)
F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch
DOI : 10.3389/fphar.2019.00198
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Poster
May 8, 2019
Aerosol evolution and deposition in the human upper respiratory tract
-
Poster
May 9, 2019
Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen
S Steiner, S Ferreira, M Morelli, A Baldi, A Kuczaj, S Frentzel, M Van der Toorn, M Peitsch, J Hoeng
-
Peer-Reviewed Publication
April 11, 2019
Systems toxicology meta-analysis – from aerosol exposure to nanotoxicology
M Talikka, V Belcastro, S Gubian, F Martin, M Peitsch, J Hoeng
DOI : 10.1016/j.cotox.2019.03.010
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Peer-Reviewed Publication
April 27, 2019
Platform 1
Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions
M Mitova, N Bielik, P B Campelos, C Cluse, C Goujon-Ginglinger, A Jaquier, M G Lueso, S Maeder, C Pitton, L Poget, J Polier-Calame, M Rotach, E G R Rouget, M Schaller, M Tharin, V Zaugg
Air Quality, Atmosphere & Health
DOI : 10.1007/s11869-019-00697-6
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Presentation
April 9, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
J Hoeng, C Foong, F Lucci, D Yeo, J Chua, A Kuczaj, M Peitsch
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PublicationPoster
March 12, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
C Foong, M J Oldham*, F Lucci, S. Cockram*, S. Luke*, D Yeo, J Chua, J Hoeng, M Peitsch, A Kuczaj
* This author is not affiliated with PMI. -
PublicationPoster
March 12, 2019
Nicotine-Containing E-Vapor Products
Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
-
PublicationPoster
March 12, 2019
Nicotine-Containing E-Vapor Products
Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment
A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
March 12, 2019
Heated Tobacco Products
Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical
S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch
-
Presentation
April 4, 2019
Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence
L Bovet, A Hilfiker, JND Battey, N Sierro, S Goepfert
-
PublicationPoster
March 12, 2019
Human multi-organ-chip co-culture approach of bronchial airway and liver models for substance exposure studies
S Frentzel, K Schimek*, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, A Winter*, U Marx*, J Hoeng
* This author is not affiliated with PMI. -
Clinical Study
February 12, 2019
Platform 1
A controlled, open-label, 3-arm parallel group, multi-center study to evaluate the Abdominal Aortic Aneurysm (AAA) growth rate in adult smoking patients randomized to either cigarette smoking or Platform 1 use and to compare with the AAA growth rate in patients who had stopped smoking
PMI
-
Methods and Protocols
March 28, 2019
Platform 1
Analysis of hydrogen cyanide in Platform 1 aerosol
PMI
-
Methods and Protocols
March 28, 2019
Platform 1
Analysis of seven phenolic compounds in THS aerosol
PMI
-
Presentation
March 27, 2019
Assessment of potential neuroprotective effects of alkaloids in a human dopaminergic in vitro model of Parkinson’s disease
MB Fares, C Mathis, A Kondylis, O Alijevic, N Sierro, J Hoeng, M Peitsch
-
Presentation
March 17, 2019
How human presence and activities of daily living influence indoor air quality
M Mitova, M Tharin, M Rotach, C Goujon-Ginglinger
-
Report
March 20, 2019
Platform 1
Summary of Evidence of Effects of IQOS on Endothelial function
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
-
Poster
March 16, 2019
Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats
AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng
-
Peer-Reviewed Publication
March 18, 2019
GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1093/bioinformatics/btz187
-
Peer-Reviewed Publication
March 18, 2019
Platform 1
Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2019.03.007
-
Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
-
Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
-
Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
-
Poster
March 12, 2019
GladiaTOX: global assessment of dose-response indicators in toxicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
-
Presentation
March 14, 2019
Nicotine-Containing E-Vapor Products
A six-month inhalation study in ApoE -/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke
-
Peer-Reviewed Publication
February 27, 2019
Optimization of a Novel In Situ Hybridization Technology on 3D Organotypic Cell Cultures
L Neau, C Lorin, S Frentzel, J Hoeng, A Iskandar, P Leroy, K Trivedi
DOI : 10.1089/aivt.2018.0021
-
Peer-Reviewed Publication
March 5, 2019
Platform 4
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Internal and Emergency Medicine
DOI : 10.1007/s11739-019-02055-x
-
Peer-Reviewed Publication
February 25, 2019
Platform 1
Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes
G Jaccard, D Tafin Djoko, A Korneliou, R Stabbert, M Belushkin, M Esposito
DOI : 10.1016/j.toxrep.2019.02.009
-
Presentation
March 4, 2019
Platform 1
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Events: Translating Basic Science into Clinical Benefit
C Pater
-
Presentation
March 4, 2019
Tabakerhitzer (Heat-not-Burn): Das Potenzial für Harm Reduction
A Nussbaum
-
Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng
-
Poster
February 22, 2019
Platform 1
Differences in Perceived Health Risk of Cigarettes and IQOS® by Current Product Use Categories and Intention to Quit: A Cross-Sectional Study in Japan
E Spies, M Dobrynina, G Kallischnigg, B Zwisele*, C Chrea, L Prieto, P Langer, R Weitkunat
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Platform 1
Test-Retest Reliability of the Lifestyle Questionnaire: Post-hoc Analysis of a Smoking Cessation Study
N Mainy, G Kallischnigg, B Zwisele*, W Teck Ng, P Langer, M Hankins, C Haziza, R Weitkunat
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Psychometric Validation of the ABOUT–Dependence : A Fit-for-Purpose Instrument to Assess Global Dependence on Tobacco and Nicotine Products
C Chrea, T Salzberger, L Abetz-Webb*, E. F. Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Platform 3
Nicotine Pharmacokinetics and Subjective Effects Following Use of a Novel Nicotine-Containing Powder Product
M Bosilkovska, S Fredersdorf, J Almodovar, N Lama, BV Taranu, E Pierri, M Radicioni*, J Ancerewicz, C Haziza, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Platform 4
Nicotine Pharmacokinetics and Pharmacodynamic Effects of P4M3 Compared with Subjects’ Own Electronic Cigarette
S Fredersdorf, M Dobrynina, BV Taranu, A Teichert, J Ancerewicz, C Haziza, F Lüdicke
-
Poster
February 22, 2019
Platform 1
Impact of Switching to a Heat-Not-Burn Tobacco Product on CYP1A2 Activity: A Review of Four Clinical Studies
A van der Plas, N Blanc, C Haziza, B Titz, BV Taranu, N Ciuria, S Ciprietti, C Witt-Gonzalez, D Ancin, V Riccitelli, I D'Errico, M Pietro, L Prieto, R Weitkunat, NV Ivanov, F Lüdicke
-
Poster
February 22, 2019
Platform 1
Exploring Discriminant Capacity of Urinary CEMA as Combustion Marker in Tobacco Users - A Population Pharmacokinetic Approach
A Claussen*, A Donelli, W Copalu*, N Lama, R Weitkunat, C Haziza, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Platform 2
Decreased Levels of Biomarkers of Exposure in Smokers Switching to Carbon-Heated Tobacco Product 1.2 compared with those who continued to smoke: A Randomized, Controlled, Open-Label 90-Day Exposure Study
CT Tran, M Bosilkovska, G de La Bourdonnaye, N Blanc, M Benzimra, J Ancerewicz, C Haziza, F Lüdicke
-
Poster
February 22, 2019
Creating a Repository for the Assessment of Tobacco-Related Behavioral Outcomes: A Case Example
E Clerc, N Mainy, C Perret*, C Acquadro*, P Binggeli, C Chrea
* This author is not affiliated with PMI. -
Poster
February 22, 2019
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) Compared with Continued Smoking
C Pater, C Haziza, A Elamin, M S Ansari, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke
-
Poster
February 22, 2019
A Multicenter, Multiregional Study on Biological and Functional Changes in Healthy Adult Smokers During One Year of Continuous Smoking Abstinence
Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke
-
Poster
February 18, 2019
Platform 1
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Events: Translating Basic Science into Clinical Benefit
C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke
-
Poster
February 22, 2019
Platform 1
Sociodemographic Characteristics of “Heat-not-Burn” Product Users Compared with Cigarette Smokers: First-Year Results of a Repeated Cross-Sectional Survey in Japan
P Langer, E. F. Afolalu, L Prieto, D Skiada, M Dobrynina, Z Sponsiello Wang, G Baker, R Weitkunat, F Lüdicke
-
Poster
February 21, 2019
Platform 4
Interfacial Dynamics of the Model Pulmonary Surfactant in the Presence of Glycerol/Propylene Glycol Mixtures
TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
* This author is not affiliated with PMI. -
Poster
February 21, 2019
Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke
F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
-
Peer-Reviewed Publication
February 19, 2019
Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT™ Toolbox initiative
C Chrea, C Acquadro*, E. F. Afolalu, E Spies, T Salzberger, L Abetz-Webb*, S Cano, B Arnould*, N Mainy, R Weitkunat
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
-
Peer-Reviewed Publication
February 14, 2019
Platform 1
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
-
Peer-Reviewed Publication
February 15, 2019
Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract
H Yepiskoposyan, M Talikka, S Vavassori, F Martin, A Sewer, S Gubian, K Luettich, M Peitsch, J Hoeng
DOI : 10.3389/fgene.2019.00087
-
Peer-Reviewed Publication
February 7, 2019
Platform 1
Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches
MA Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov
DOI : 10.1016/j.cotox.2019.01.001
-
Peer-Reviewed Publication
February 12, 2019
How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models
D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.ALTEX Alternatives to Animal Experimentation
DOI : 10.14573/altex.1811221
-
Presentation
February 13, 2019
Platform 1
Harm Reduction in Smokers: Could Chronic Respiratory Disorders be Reduced?
C Haziza, F Sergio
-
Presentation
February 8, 2019
Platform 1
Chronic Toxicity and Lung Tumorigenesis in A/J Mice Following Lifetime Exposure to Aerosol from the Tobacco Heating System 2.2 in Comparison with Exposure to 3R4F Reference Cigarette Smoke
K Luettich
-
Peer-Reviewed Publication
February 5, 2019
Platform 1
Reduction In Exposure To Selected Harmful And Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence In Smokers Switching To The Menthol Tobacco Heating System 2.2 For Three Months (Part 1)
C Haziza, G de La Bourdonnaye, A Donelli, V Poux, D Skiada, R Weitkunat, G Baker, P Picavet, F Lüdicke
DOI : 10.1093/ntr/ntz013
-
Report
January 22, 2019
Platform 1
Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP)
M Nordlund, M Smith, S Maeder, T McGrath, JP Schaller, P Pratte, P Picavet, M Peitsch
-
Peer-Reviewed Publication
December 10, 2018
Platform 1
Household Surveys in the General Population and Web-Based Surveys in IQOS Users Registered at the Philip Morris International IQOS User Database: Protocols on the Use of Tobacco- and Nicotine-Containing Products in Germany, Italy, and the United Kingdom (Greater London), 2018-2020
Z Sponsiello Wang, P Langer, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke
DOI : 10.2196/12061
-
Peer-Reviewed Publication
January 3, 2019
Platform 1
New approaches to risk assessment of chemical mixtures.
AW Hayes, R Li*, J Hoeng, A Iskandar, M Peitsch, ML Dourson*
* This author is not affiliated with PMI.Toxicology Research and Application
3: 2397847318820768
-
Peer-Reviewed Publication
January 2, 2019
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.
F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.12.056
-
Peer-Reviewed Publication
December 12, 2018
Multispecies aerosol evolution and deposition in a bent pipe.
M Asgari, F Lucci, A Kuczaj
Journal of Aerosol Science 129: 53-70.
DOI : 10.1016/j.jaerosci.2018.12.007
-
Peer-Reviewed Publication
December 18, 2018
Platform 1
Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.
F Zanetti, X Zhao, J Pan*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.DOI : 10.3290/j.qi.a41601
-
Poster
December 17, 2018
Establishing the Vitrocell® Powder Chamber as a particle size-selective platform for in vitro dry powder testing
S Steiner, M Hittinger*, K Knoth*, H Gross*, S Frentzel, A Kuczaj, J Hoeng, T Krebs*, M Peitsch
* This author is not affiliated with PMI. -
Presentation
December 10, 2018
Assessing User Behavior and Risk Perceptions: A Case Study from Philip Morris International
E Spies
-
Poster
December 10, 2018
Optimization and image analysis of RNAscope ® technology on 3D human organotypic ciliated respiratory epithelial culture
L Neau, K Trivedi, P Leroy, A Iskandar, J Hoeng, S Frentzel
-
Report
December 10, 2018
Platform 1
Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
-
Peer-Reviewed Publication
November 21, 2018
A lung/liver-on-a-chip platform for acute and chronic toxicity studies
D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, K Trivedi, E Guedj, Q Dutertre, M Peitsch, J Hoeng
-
Peer-Reviewed Publication
November 29, 2018
The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production
N Sierro, JND Battey, L Bovet, V Liedschulte, S Ouadi, J Thomas, Hervé Broye, H Laparra, A Vuarnoz, G Lang, S Goepfert, M Peitsch, NV Ivanov
DOI : 10.1186/s12864-018-5241-5
-
Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
-
Peer-Reviewed Publication
November 19, 2018
Influence of smoking on levels of urinary 8-iso Prostaglandin F2α
A van der Plas, S Pouly, G de La Bourdonnaye, G Baker, F Lüdicke
DOI : 10.1016/j.toxrep.2018.11.011
-
Presentation
November 26, 2018
Heated Tobacco Products
Tobacco Harm Reduction & Reduced Risk Products
R Minhos
-
Presentation
November 26, 2018
Platform 1
Assessment of candidate modified risk tobacco products on oral health in vitro
E Veljkovic, F Zanetti
-
Presentation
November 16, 2018
Heated Tobacco Products
Methods for Tobacco Harm Reduction: Introducing the Scientific Assessment Program of PMI Science
A Nussbaum
-
Presentation
November 15, 2018
Heated Tobacco Products
Uncovering Recent ENDS Scientific Research Data
A Nussbaum
-
Presentation
November 19, 2018
Platform 1
Respiratory Effects Observed When Using the Tobacco Heating System (THS) Compared with Continued Smoking
-
Report
November 20, 2018
Platform 1
Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS
-
Presentation
November 16, 2018
Heated Tobacco Products
"Risikoreduzierte“ Tabakprodukte Zukunftsoption des Rauchens?
E Helmle
-
Poster
November 15, 2018
Development of a fit-for-purpose tobacco and nicotine product dependence instrument
C Chrea, T Salzberger, L Abetz-Webb*, E. F. Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
* This author is not affiliated with PMI. -
Poster
November 15, 2018
Platform 1
Modeling the population years of life saved by introducing a reduced risk product in the US and in Japan
S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva
-
Peer-Reviewed Publication
November 12, 2018
BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site
J Gordeeva*, N Morozova*, N Sierro, A Isaev*, T Sinkunas*, K Tsvetkova*, M Matlashov*, L Truncaitė*, RD Morgan*, NV Ivanov, V Siksnys*, L Zeng*, K Severinov*
* This author is not affiliated with PMI.DOI : 10.1093/nar/gky1125
-
Peer-Reviewed Publication
November 14, 2018
Platform 1
Investigation of menthol content and transfer rates in cigarettes and Tobacco Heating System 2.2
G Jaccard, M Belushkin, C Jeannet, EN Aldilla, AO Wijoyo
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2018.11.004
-
Poster
November 14, 2018
Measurement Properties of translated versions of measures assessing the subjective effects of tobacco and nicotine containing products: A literature review
C Acquadro*, C Desvignes-Gleizes*, N Mainy, B Arnould*, E Spies, M Hankins, R Weitkunat, C Chrea
* This author is not affiliated with PMI. -
Poster
November 8, 2018
The impact of exposure to cigarette smoke on the secreton of inflammatory mediators: Assessment using human organotypic small airway epithelial cultures from five different donors
C Merg, M Corciulo, A Giralt, A Kondylis, L Ortega Torres, S Majeed, T Schneider, A Iskandar, NV Ivanov, J Hoeng
-
Peer-Reviewed Publication
November 9, 2018
Platform 1
Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke
MA Choukrallah, N Sierro, F Martin, K Baumer, J Thomas, S Ouadi, J Hoeng, M Peitsch, NV Ivanov
DOI : 10.1016/j.fct.2018.11.020
-
Presentation
November 12, 2018
Platform 1
TOBACCO HARM REDUCTION: An Overview of PMI’s Scientific Approach & Main Results for the Tobacco Heating System (THS) 2.2, a Candidate Modified Risk Tobacco Product
N Fazenda
-
Peer-Reviewed Publication
October 3, 2018
Embracing Transparency Through Data Sharing
S Boue, M Byrne*, AW Hayes, J Hoeng, M Peitsch
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581818803880
-
Presentation
November 7, 2018
How innovation will deliver a smoke-free future
R Minhos
-
Presentation
November 7, 2018
Development of a Novel In Vitro Aerosol Exposure System: the Independent Holistic Air Liquid Aerosol Exposure System (InHALES)
S Steiner
-
Poster
October 29, 2018
Heated Tobacco Products
Development of a new outcome measure to assess the impact of reduced-risk tobacco- and nicotine-containing products on health and functioning: a comprehensive literature search
E Spies, L Abetz-Webb*, S Gallot, E. F. Afolalu, C Chrea, R Weitkunat
* This author is not affiliated with PMI. -
Presentation
October 29, 2018
Alternatives to cytotoxicity assessment of eliquids using the neutral red uptake assay
D McHugh, G Cudazzo, P Vanscheeuwijck
-
Poster
October 29, 2018
Platform 1
Patterns of Use Behaviors in a Sample of Japanese "Heat-Not-Burn" Tobacco Product (IQOS®) Users
E. F. Afolalu, P Langer, L Prieto, D Skiada, M Dobrynina, Z Sponsiello Wang, R Weitkunat, F Lüdicke
-
Poster
October 29, 2018
Platform 1
Cross-Sectional Surveys on the Use of Tobacco Products in the General Population and in Users of IQOS in Germany, Italy, and London (2018-2020): Introducing the Study Protocols
Z Sponsiello Wang, P Langer, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke
-
Peer-Reviewed Publication
October 17, 2018
Platform 1
Development and validation of a method for quantification of two tobacco-specific nitrosamines in indoor air
M G Lueso, M Mitova, N Mottier, M Schaller, M Rotach, C Goujon-Ginglinger
DOI : 10.1016/j.chroma.2018.10.037
-
Peer-Reviewed Publication
October 20, 2018
Platform 1
Estimating the population health impact of introducing a reduced-risk tobacco product into Japan. The effect of differing assumptions, and some comparisons with the U.S.
PN Lee*, S Djurdjevic, R Weitkunat, G Baker
* This author is not affiliated with PMI. -
Presentation
September 1, 2018
Platform 1
Smoking and Non-Communicable Diseases in Hong Kong
D Khayat*
* This author is not affiliated with PMI. -
Presentation
August 30, 2018
Platform 1
Cancer and its Causes in Korea
D Khayat*
* This author is not affiliated with PMI. -
Poster
October 19, 2018
Numerical characterization of aerosol exposure systems: an analytical model to predict dose deposition
F Lucci, A Kuczaj
-
Presentation
October 15, 2018
Platform 1
Modeling the population health impact of introducing a reduced-risk product into the Japan market
S Djurdjevic, K Murakami
-
Poster
October 8, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke
-
Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Presentation
September 27, 2018
Assessment of candidate modified risk tobacco products on oral health in vitro
F Zanetti, J Hoeng
-
Poster
September 27, 2018
Platform 1
Discriminating Spontaneous Tumors from Exposure Induced Tumors in the A/J Mouse Lung Cancer Model
Y Xiang, F Martin, K Luettich, K Trivedi, E Guedj, E T Wong, J Hoeng, M Peitsch
-
Poster
September 24, 2018
Platform 1
Novel Trapping System for the Quantification of Two Tobacco-Specific Nitrosamines in Indoor Air
M G Lueso, M Schaller, M Mitova, M Rotach, C Goujon-Ginglinger
-
Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
-
Poster
September 10, 2018
Characterization of the Aerosol Flow, Sampling, and Deposition in a Nose Only Exposure Chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 21, 2018
Development and validation of a new instrument to measure perceived risks associated with the use of tobacco and nicotine-containing products
S Cano, C Chrea, T Salzberger, T Alfieri*, G Emilien, N Mainy, A Ramazzotti, F Lüdicke, R Weitkunat
* This author is not affiliated with PMI.Health and Quality of Life Outcomes
DOI : 10.1186/s12955-018-0997-5
-
Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
-
Poster
September 10, 2018
Enabling Systems Toxicology Assessment Studies with State-of-the-Art Biospecimen Information Management Systems
E Dargaud, S Ansari
-
Poster
September 10, 2018
Fourier Transformed Infrared (FTIR) Method For Continuous Real-Time Aerosol Characterization For In Vivo Studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Presentation
September 10, 2018
Numerical Model for the Aerosol Formation Process in an Electrically Heated Tobacco Product
-
Presentation
September 10, 2018
A novel method for multi-component continuous real-time aerosol monitoring using Fourier Transformed Infrared (FTIR) spectroscopy for in vivo studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 3, 2018
RPackUtils: R Package Dependencies Manager and Bioconductor & CRAN Mirroring Tool
S Cano, S Gubian
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Poster
September 7, 2018
Characterization of a lung-liver organ-on-a-chip model
D Bovard, A Sandoz, M Morelli, D Marescotti, K Trivedi, K Luettich, S Frentzel, J Hoeng
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Poster
September 7, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Poster
September 7, 2018
Development of a novel in vitro aerosol exposure system: the Independent Holistic Air Liquid Exposure System (InHALES)
S Steiner, P Hervé, S Majeed, C Pak, A Kuczaj, S Frentzel, J Hoeng
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Peer-Reviewed Publication
August 24, 2018
Platform 1
Evaluation of Biological and Functional Changes in Healthy Smokers Switching to the Tobacco Heating System 2.2 Versus Continued Tobacco Smoking: Protocol for a Randomized, Controlled, Multicenter Study
M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, F Lüdicke
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Poster
August 16, 2018
Platform 1
Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry
A Knorr, E Martin, M Almstetter, A Castellon, P Pospisil, M Bentley
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Publication
August 16, 2018
Platform 1
Non-targeted screening using GC×GC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product
M Almstetter, A Knorr, M Rhouma, E Martin, A Castellon, P Pospisil, M Bentley
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Poster
August 16, 2018
Platform 1
In-depth characterization of chemical differences between heat-not-burn tobacco products and cigarettes using LC-HRAM-MS-based non-targeted differential screening (NTDS)
D Arndt, C Wachsmuth, C Buchholz, M Bentley
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Poster
August 20, 2018
Agile Implementation of Automated Processes Using the BIOVIA Pipeline Pilot System
E Martin, A Castellon, M Bentley, P Pospisil
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Presentation
August 20, 2018
Building an Efficient R&D Chemo-Centric Data Repository System that Leads to Knowledge Discovery
P Pospisil, E Martin, A Castellon, M Bentley
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Data
April 10, 2018
Platform 1
90-day OECD rat inhalation study with THS 2.2 (TG413 guideline)
PMI
-
Poster
July 9, 2018
Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge
C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI. -
Poster
July 30, 2018
Platform 1
Air quality assessment during indoor use of the Tobacco Heating System THS 2.2
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Poster
June 8, 2018
Comprehensive chemical characterization of complex matrices through integration of multiple analytical modes and databases for LC-HRAMMS-based non-targeted screening
C Wachsmuth, D Arndt, E Martin, C Buchholz, M Bentley
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Poster
June 8, 2018
Platform 1
In-depth characterization of chemical differences between heat-not-burn tobacco products and cigarettes using LC-HRAMMS-based non-targeted differential screening (NTDS)
D Arndt, C Wachsmuth, C Buchholz, M Bentley
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Poster
July 20, 2018
Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence
L Bovet, A Lenglet, JND Battey, S Goepfert
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Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Book Chapter
June 20, 2018
Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling
Bioinformatics in the Era of Post Genomics and Big Data
DOI : 10.5772/intechopen.75970
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Peer-Reviewed Publication
June 1, 2018
Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations
G Lacroix*, W Koch*, D Ritter*, AC Gutleb*, ST Larsen*, T Loret*, F Zanetti, S Constant*, S Chortarea*, B Rothen-Rutishauser*, PS Hiemstra*, E Frejafon*, P Hubert*, L Gribaldo*, P Kearns*, JM Aublant*, S Diabaté*, C Weiss*, A de Groot*, I Kooter*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Clinical Study
January 13, 2017
Platform 1
An Observational Cohort Study in Japan to Assess the Patterns of Product Use and Changes in Health Outcomes Associated With the Use of HeatSticks With the Tobacco Heating System
PMI
-
Clinical Study
November 10, 2010
A European, Multi-centre Study to Determine the Exposure of Adult Smokers and Non-smokers to Cigarette Smoke Constituents
PMI
-
Clinical Study
January 31, 2013
Platform 1
A Single-center, Open-label, Randomized, Controlled, Crossover Study to Explore the Nicotine Pharmacokinetic Profile and Safety of Tobacco Heating System (THS) 2.1 Compared to Conventional Cigarettes Following Single and ad Libitum Use in Smoking, But Otherwise Healthy Subjects.
PMI
-
Clinical Study
January 31, 2013
Platform 1
A Single-center, Open-label, Randomized, Controlled, 2-arm Parallel Group Study to Evaluate the Exposure to Selected Smoke Constituents in Smoking, But Otherwise Healthy Subjects Switching From Conventional Cigarettes to the Tobacco Heating System (THS) 2.1
PMI
-
Clinical Study
December 7, 2017
Platform 1
A 6-month Randomized, Controlled, Open-label, 2-arm Parallel Group, Multicenter Study to Evaluate the Effect of Switching From Cigarette Smoking to the Use of Platform 1 in Smokers With Generalized Chronic Periodontitis on the Response to Mechanical Periodontal Treatment and Oral Health Status.
PMI
-
Clinical Study
December 20, 2017
Platform 4
A Single-center, Open-label, Concentration-ranging Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of the P4M3 Variants
PMI
-
Clinical Study
May 16, 2018
Platform 1
Cross Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in Italy (2018-2020)
PMI
-
Clinical Study
May 16, 2018
Platform 1
Cross-Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in Germany (2018-2020)
PMI
-
Clinical Study
May 16, 2018
Platform 1
Cross Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in London (2018-2020)
PMI
-
Clinical Study
June 11, 2018
Platform 1
Assessment of passive environmental aerosol exposure through the Tobacco Heating System (THS) in a restaurant setting where THS use, but not cigarette smoking, is allowed
PMI
-
Peer-Reviewed Publication
June 30, 2018
Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency
F Lucci, ND Castro*, AA Rostami*, M J Oldham*, J Hoeng, YB Pithawalla*, A Kuczaj
* This author is not affiliated with PMI.Volume 123, September 2018, Pages 141-160
DOI : 10.1016/j.jaerosci.2018.06.015
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Peer-Reviewed Publication
July 9, 2018
Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures
S Steiner, P Diana, E Dossin, P Guy, G Vuillaume, A Kondylis, S Majeed, S Frentzel, J Hoeng
DOI : 10.1016/j.tiv.2018.06.024
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Peer-Reviewed Publication
July 2, 2018
Platform 1
Role of testing standards in smoke-free product assessments
M Belushkin, M Esposito, G Jaccard, C Jeannet, A Korneliou, D Tafin Djoko
Regulatory Toxicology and Pharmacology
Volume 98, October 2018, Pages 1-8
DOI : 10.1016/j.yrtph.2018.06.021
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Peer-Reviewed Publication
June 12, 2011
Modeling Early Initiation Processes in Smoking-Induced Lung Adenocarcinomas
G Vuillaume, T Mueller, M Talikka, Y Cheng, G Diserens, M Peitsch, J Hoeng, F Tobin*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
January 1, 2017
Menthol Cigarettes, Time to First Cigarette, and Smoking Cessation
EB Sanders, R Weitkunat, R Dempsey
-
Peer-Reviewed Publication
March 1, 2017
The Adverse Outcome Pathway for Oxidative Stress-Mediated EGFR Activation Leading to Decreased Lung Function
K Luettich, M Talikka, FJ Lowe*, LE Haswell, J Park*, M Gaca*, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 1, 2017
Development of an adverse outcome pathway for the onset of hypertension by oxidative stress-mediated perturbation of endothelial nitric oxide bioavailability
FJ Lowe*, K Luettich, M Talikka, V Hoang*, LE Haswell, J Hoeng, M Gaca*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 31, 2017
Systems toxicology: Real World Applications and Opportunities
T Hartung*, RE FitzGerald*, P Jennings*, Gary R. Mirams*, M Peitsch, A Rostami-Hodjegan*, I Shah*, MF Wilks*, SJ Sturla*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 5, 2017
Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.
S Boue, T Exner*, D Ghosh, V Belcastro, J Dokler*, D Page, A Boda, F Bonjour, B Hardy*, P Vanscheeuwijck, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 19, 2016
Evaluation of oscillation-free fluid-porous interface treatments for segregated finite volume flow solvers
M Stanic*, M Nordlund, EM Frederix*, A Kuczaj, BJ Geurts*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 30, 2018
Advancing Risk Assessment through the Application of Systems Toxicology.
JM Sauer*, A Kleensang*, M Peitsch, AW Hayes
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
January 22, 2016
Heterocyclic aromatic amines and their contribution to the bacterial mutagenicity of the particulate phase of cigarette smoke.
E Roemer, T Meisgen, J Diekmann, LL Conroy, R Stabbert
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Peer-Reviewed Publication
May 15, 2016
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
U Marx*, TB Andersson *, A Bahinski*, M Beilmann*, S Beken*, FR Cassee*, M Cirit*, M Daneshian *, S Fitzpatrick*, O Frey *, C Gaertner*, C Giese *, L Griffith *, T Hartung*, MB Heringa*, J Hoeng, WH de Jong *, H Kojima*, J Kuehnl*, M Leist*, A Luch *, I Maschmeyer*, D Sakharov*, AJAM Sips*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, T Tralau*, S Tsyb*, A van de Stolpe *, R Vandebriel*, P Vulto*, J Wang*, J Wiest*, M Rodenburg*, A Roth*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
August 20, 2016
Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)
J Fluck*, S Madan*, S Ansari, AT Kodamullil*, R Karki*, M Rastegar-Mojarad*, NL Catlett*, WS Hayes, J Szostak, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 31, 2016
Improved knowledge acquisition and creation of structured knowledge for systems toxicology.
S Ansari, J Szostak, M Talikka, J Fluck*, J Hoeng
* This author is not affiliated with PMI.International Journal On Advances in Life Sciences
Int J Adv Life Sci 8: 309-319.
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Peer-Reviewed Publication
January 5, 2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI. -
Presentation
June 9, 2018
Platform 1
Thermal decomposition behavior of the tobacco material used in a heated tobacco product
-
Poster
June 8, 2018
Platform 1
Non-targeted screening using GC×GC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product
M Almstetter, A Knorr, M Rhouma, E Martin, A Castellon, P Pospisil, M Bentley
-
Poster
June 8, 2018
Platform 1
Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry
A Knorr, E Martin, M Almstetter, A Castellon, P Pospisil, M Bentley
-
Poster
June 8, 2018
Increasing confidence for compound identification by fragmentation database and in silico fragmentation comparison with LC-HRAM-MS-based non-targeted screening of complex matrices
C Buchholz, D Arndt, C Wachsmuth, M Bentley
-
Peer-Reviewed Publication
June 20, 2018
Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity
AJ Clippinger*, D Allen*, HP Behrsing *, KA BéruBé*, MB Bolger*, W Casey*, M DeLorme*, M Gaca*, SC Gehen*, K Glover*, P Hayden*, P Hinderliter*, JA Hotchkiss*, A Iskandar, B Keyser*, K Luettich, L Ma-Hock*, A Maione*, P Makena*, J Melbourne*, L Milchak*, SP Ng*, A Paini*, K Page*, G Patlewicz*, P Prieto*, H Raabe*, EN Reinke*, C Roper*, J Rose*, M Sharma*, W Spoo*, PS Thorne*, DM Wilson*, AM Jarabek*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 9, 2018
Modeling the impact of changes in tobacco use on individual disease risks
S Djurdjevic, Z Sponsiello Wang, PN Lee*, JS Fry*, R Weitkunat, F Lüdicke, G Baker
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 22, 2018
Platform 4
Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures
TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2018.1478916
-
Peer-Reviewed Publication
June 16, 2018
Platform 1
Investigation and comparison of the transfer of TSNA from tobacco to cigarette mainstream smoke and to the aerosol of a heated tobacco product, THS2.2
G Jaccard, A Kondylis, I Gunduz, J Pijnenburg, M Belushkin
-
Peer-Reviewed Publication
January 18, 2015
Synergy, suppression and immorality: forward differences of the entropy function.
J Whittaker*, F Martin, Y Xiang
* This author is not affiliated with PMI.1501.04368
-
Peer-Reviewed Publication
June 17, 2015
Construction of biological networks from unstructured information based on a semi-automated curation workflow.
J Szostak, S Ansari, S Madan*, J Fluck*, M Talikka, A Iskandar, H De Leon, M Hofmann-Apitius*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/database/bav057
-
Peer-Reviewed Publication
March 23, 2015
Systems Toxicology: The Future of Risk Assessment.
JM Sauer*, T Hartung*, M Leist*, TB Knudsen*, J Hoeng, AW Hayes
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
May 1, 2015
An Improved GC-MS Method for Cigarette Smoke Characterization Using a Novel Cold Trap, Dual Column, and Cryofocusing System
M Rotach, E G R Rouget, J R Crudo
Volume 28, Issue 5, pg 258–264
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Peer-Reviewed Publication
May 19, 2015
Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas–vapor phase of cigarette smoke.
E Roemer, V Zenzen, LL Conroy, K Luedemann, R Dempsey, C Schunck*, E TrellesSticken*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 2, 2015
Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion.
-
Peer-Reviewed Publication
November 3, 2014
Differences in cadmium transfer from tobacco to cigarette smoke, compared to arsenic or lead
JJ Piadé, G Jaccard, C Dolka, M Belushkin, S Wajrock
-
Peer-Reviewed Publication
May 26, 2015
Median estimation of chemical constituents for sampling on two occasions under a log-normal model.
A Kondylis
-
Peer-Reviewed Publication
August 13, 2015
Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.
U Kogel, I Gonzalez-Suarez, Y Xiang, E Dossin, P Guy, C Mathis, D Marescotti, D Goedertier, F Martin, M Peitsch, J Hoeng
-
Peer-Reviewed Publication
February 15, 2015
Where are we at regarding species translation? A review of the sbv IMPROVER challenge.
J Hoeng, M Peitsch, P Meyer*, I Jurisica
* This author is not affiliated with PMI.Volume 31, Issue 4, Pages 451–452,
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Peer-Reviewed Publication
April 30, 2015
Extension of the compressible PISO algorithm to single-species aerosol formation and transport
EM Frederix*, M Stanic*, A Kuczaj, M Nordlund, BJ Geurts*
* This author is not affiliated with PMI.International Journal of Multiphase Flow
Volume 74, September 2015, Pages 184-194
DOI : 10.1016/j.ijmultiphaseflow.2015.04.015
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Peer-Reviewed Publication
June 25, 2015
Considerations for comparative tobacco product assessments based on smoke constituent yields
M Belushkin, G Jaccard, A Kondylis
Regulatory Toxicology and Pharmacology
Volume 73, Issue 1, October 2015, Pages 105-113
DOI : 10.1016/j.yrtph.2015.06.017
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Peer-Reviewed Publication
February 7, 2014
Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons
BSP Schreiner*, R Lehmann*, U Thiel*, PM Ziemba*, LR Beltrán*, MA Sherkheli*, P Jeanbourquin, A Hugi, M Werner*, G Gisselmann*, H Hatt*
* This author is not affiliated with PMI.European Journal of Pharmacology
Volume 728, 5 April 2014, Pages 48-58
DOI : 10.1016/j.ejphar.2014.01.060
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Peer-Reviewed Publication
June 13, 2014
A decade of Systems Biology: where are we and where are we going to?
M Peitsch, D de Graaf*
* This author is not affiliated with PMI.DOI : 10.1016/j.drudis.2013.06.002
-
Peer-Reviewed Publication
January 1, 2013
A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.
JW Westra*, W Schlage, A Hengstermann*, S Gebel*, C Mathis, TM Thomson, B Wong*, V Hoang*, E Veljkovic, M Peck, RB Lichtner, D Weisensee, M Talikka, R Deehan*, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
November 11, 2013
Computer-assisted structure identification (CASI)--an automated platform for high-throughput identification of small molecules by two-dimensional gas chromatography coupled to mass spectrometry.
A Knorr, A Monge, M Stueber, A Stratmann, D Arndt, E Martin, P Pospisil
-
Peer-Reviewed Publication
December 5, 2013
Assessing smoking behaviour and tobacco smoke exposure: definitions and methods
E Gregg*, T Bachmann, R Bito*, X Cahours*, M McEwan*, P Nelson*, K Prasad*, G Scherer*, M Stiles*
* This author is not affiliated with PMI.Beiträge zur Tabakforschung International
Volume 25, No. 8
-
Peer-Reviewed Publication
August 15, 2013
Menthol addition to cigarettes using breakable capsules in the filter. Impact on the mainstream smoke yields of the Health Canada list constituents.
C Dolka, JJ Piadé, M Belushkin, G Jaccard
Chemical Research in Toxicology
DOI : 10.1021/tx400146x
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Peer-Reviewed Publication
January 12, 2012
Does the use of ingredients added to tobacco increase cigarette addictiveness?: a detailed analysis.
EB Sanders, R Weitkunat, A Utan, R Dempsey
DOI : 10.3109/08958378.2012.663006
-
Peer-Reviewed Publication
February 6, 2012
Headspace Volumetric Karl Fischer Titration for the Determination of Water Content in Finished Tobacco Products
N Aydin, F Chardonnens, M Rotach
-
Peer-Reviewed Publication
February 14, 2011
Limitations of cigarette machine smoking regimens.
E Roemer, RA Carchman*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 10, 2011
Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study.
D Lindner, S Smith*, C Martin Leroy, A R Tricker
* This author is not affiliated with PMI.Cancer Epidemiology, Biomarkers & Prevention
DOI : 10.1158/1055-9965.EPI-10-1186
-
Peer-Reviewed Publication
December 13, 2010
Cigarette smoke enhances abdominal aortic aneurysm formation in angiotensin II-treated apolipoprotein E-deficient mice.
K Stolle, A Berges, M Lietz, S Lebrun, T Wallerath
-
Peer-Reviewed Publication
December 30, 2014
The Addition of Cocoa, Glycerol, and Saccharose to the Tobacco of Cigarettes: Implications for Smoke Chemistry, In Vitro Cytotoxicity, Mutagenicity and Further Endpoints
E Roemer, S Wittke, E TrellesSticken*, JJ Piade*, T Bonk, MK Schorp*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 10, 2009
Biotransformation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Lung Tissue from Mouse, Rat, Hamster, and Man
E Richter*, J Engl*, S Friesenegger*, A R Tricker
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 30, 2014
A Modelling Approach to Develop Machine Smoking Protocols Reflecting Human Puffing Behaviour for Conventional Cigarettes
HJ Urban, W Gomm, MK Schorp*
* This author is not affiliated with PMI.DOI : 10.2478/cttr-2013-0844
-
Peer-Reviewed Publication
January 10, 2009
Systematic review of the relation between smokeless tobacco and cancer of the pancreas in Europe and North America
Z Sponsiello Wang, R Weitkunat, PN Lee*
* This author is not affiliated with PMI. -
Infoposter
June 15, 2018
Platform 1
Product experience and risk perceptions in Platform 1 users: a cross-sectional survey in Japan
P Langer, Z Sponsiello Wang, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke
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Infoposter
June 15, 2018
Potential Predictors of Intended Use of a Novel Heat-Not-Burn Tobacco Product
F Beacher, PP Magnani, A Ramazzotti, S Colman*, F Lüdicke, R Weitkunat, G Kallischnigg, B Zwisele*
* This author is not affiliated with PMI. -
Infoposter
June 15, 2018
A Multi-Center, Multi-Regional, Study on Biological and Functional Changes in Healthy Adult Smokers during One Year of Continuous Smoking Abstinence
C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Infoposter
June 15, 2018
Modeling the Population Health Impact of introducing a Reduced Risk Product into the Japan market
S Djurdjevic, G Baker, T Iida, E Konishi, F Lüdicke
-
Infoposter
June 15, 2018
Evaluation of biological and functional changes in healthy smokers after switching from cigarettes to Tobacco Heating System (THS) 2.2 for 6 months
S Ansari, N Lama, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Infoposter
June 15, 2018
Assessing consumer responses to reduced risk products: experience at Philip Morris International in developing fit-for-purpose self-report instruments
C Chrea, E Spies, E Afolalu, N Mainy, S Gallot, P Binggeli, E Clerc, R Weitkunat, T Salzberger, S Cano, C Acquadro*, B Arnould*, V Brunel*, J Lambert*, C Marcuccilli*, L Abetz-Webb*, Jed E Rose PhD*, K Fagerström*
* This author is not affiliated with PMI. -
Presentation
June 15, 2018
Platform 1
Changes in Biological and Functional Markers after Six Months, in Three Populations: THS 2.2 (IQOS) Users, Continued Smokers, and Smoking Abstinence
C Haziza
-
Poster
June 11, 2018
Platform 1
Changes in Clinical Risk Endpoints Linked to Cardiovascular and Other Smoking-Related Diseases after Switching from Cigarettes to the Tobacco Heating System (THS) 2.2 for Six Months
C Haziza, S Ansari, N Lama, M Bosilkovska, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, F Lüdicke
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Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Methods and Protocols
June 7, 2018
Platform 1
Analysis of water, nicotine, triacetin in Platform 1 aerosol
PMI
-
Methods and Protocols
June 7, 2018
Platform 1
Analysis of volatiles and semi-volatiles in Platform 1 Aerosol
PMI
-
Peer-Reviewed Publication
March 7, 2018
Physiological and biological characterization of smokers with and without COPD.
N Chaudhary, K Luettich, M Peck, E Pierri, Loyse Felber Medlin , G Vuillaume, P Leroy, J Hoeng, M Peitsch
-
Book Chapter
May 23, 2018
Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases
Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy
DOI : 10.5772/intechopen.69569
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Poster
May 25, 2018
Enabling Systems Toxicology Assessment Studies with State-of-the-Art Biospecimen Data Management Systems
E Dargaud, S Ansari
-
Peer-Reviewed Publication
May 10, 2018
SolCyc: a database hub at the Sol Genomics Network (SGN) for the manual curation of metabolic networks in Solanum and Nicotiana specific databases
H Foerster*, A Bombarely*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI. -
Presentation
April 27, 2018
Platform 1
Clinical assessment of products aiming at reducing the risk of use compared with continued cigarette smoking
A Donelli
-
Poster
May 9, 2018
Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology
C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 5, 2018
Platform 4
Establishing the baseline effects of non-flavoured e-liquids and flavour compounds in the in vitro micronucleus assay
D Smart, P Vanscheeuwijck, D McHugh, E Nallet, FR Helbling
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Poster
May 5, 2018
Mode-of-action analysis of a positive in vitro micronucleus finding in CHO-WBL cells
D McHugh, P Vanscheeuwijck, FR Helbling, D Smart
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Presentation
May 5, 2018
Nicotine-Containing E-Vapor Products
Mode-of-action analysis of genotoxicity detected by the in vitro micronucleus assay: two industry case studies
D Smart
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Presentation
May 21, 2018
Platform 1
Molecular biomarkers elucidate the role of inflammation and oxidative stress in smoking-related diseases
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Peer-Reviewed Publication
April 19, 2018
Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B2
A van der Plas, S Pouly, G de La Bourdonnaye, W Teck Ng, G Baker, F Lüdicke
DOI : 10.1016/j.toxrep.2018.04.005
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Peer-Reviewed Publication
May 7, 2018
Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science
M Peitsch, R Polosa*, C Proctor*, T Hassler*, M Gaca*, E Hill*, J Hoeng, AW Hayes
* This author is not affiliated with PMI. -
Presentation
April 11, 2018
A review of analytical approaches to assess transitions in patterns of tobacco product use in the population
E Afolalu
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Peer-Reviewed Publication
May 16, 2018
Platform 1
Modeling the Population Health Impact of Introducing a Modified Risk Tobacco Product into the U.S. Market
S Djurdjevic, PN Lee*, R Weitkunat, Z Sponsiello Wang, F Lüdicke, G Baker
* This author is not affiliated with PMI.DOI : 10.3390/healthcare6020047
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Report
May 9, 2016
Appendix 2: Independent Expert Risk Benefit Assessment
R Bass*
* This author is not affiliated with PMI. -
Report
May 27, 2016
Appendix 1: Expert Report of Prof. Dr. Valerio Cozzani
V Cozzani*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Peer-Reviewed Publication
December 14, 2017
Platform 1
Pre-market studies from five countries in Asia and Europe to measure the adoption of the tobacco heating system (THS) in smokers
S Roulet, N Mainy, C Chrea, PP Magnani, R Weitkunat, G Kallischnigg, A Ramazzotti
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Peer-Reviewed Publication
December 15, 2017
Perceived risks associated with the use of tobacco and nicotine-containing products: Findings from qualitative research
T Salzberger, C Chrea, S Cano, M Martin, M Atkison*, G Emilien, N Mainy, A Ramazzotti, R Weitkunat, F Lüdicke
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 10, 2017
Nicotine-Containing E-Vapor Products
In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use.
HP Behrsing *, R Devlin*, R Tice*, S Fitzpatrick*, H Raabe*, E Hill*, K Pinkerton*, G Oberdörster*, C Wright*, R Wieczorek*, M Aufderheide*, S Steiner, T Krebs*, B Asgharian*, R Corley*, M J Oldham*, J Adamson*, X Li*, I Rahman*, S Grego*, PH Chu*, S McCullough*, R Curren*
* This author is not affiliated with PMI.45(3): 117-158.
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Peer-Reviewed Publication
October 18, 2017
Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways
EM Frederix*, A Kuczaj, M Nordlund, M Belka*, F Lizal*, J Jedelsky*, J Elcner*, M Jicha*, BJ Geurts*
* This author is not affiliated with PMI.DOI : 10.1016/j.jaerosci.2017.10.007
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
March 16, 2018
Four-Week Continuous Nicotine Treatment of Immortalized Bronchial Epithelial Cells Does Not Contribute to Tumorigenesis
M Van der Toorn, K Baumer, D Peric, D Bornand, R Dulize, E Guedj, A Sewer, D Marescotti, K Luettich, NV Ivanov, M Peitsch, J Hoeng
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Poster
March 16, 2018
Platform 1
Characterization of clones derived from human bronchial epithelial cells after long-term treatment with TPM from reference cigarettes versus THS 2.2
M Van der Toorn, M Sgandurra, D Marescotti, M Peitsch, J Hoeng, K Luettich
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Poster
March 16, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Poster
March 16, 2018
Human In Vitro Models for Respiratory Toxicology: Evaluation of Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays
S Frentzel, M Aragon*, J Hoeng, S Ito*, S Ishikawa*, J Budde*, A Maione*, P Hayden*, W Fields*, B Keyser*, LE Haswell, D Azzopardi*, HP Behrsing *
* This author is not affiliated with PMI. -
Poster
March 9, 2018
Platform 1
Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome
C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 7, 2018
Platform 1
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product
M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich
DOI : 10.1016/j.tiv.2018.02.019
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Peer-Reviewed Publication
March 1, 2018
Platform 2
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.063
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Peer-Reviewed Publication
March 2, 2018
Platform 2
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens
F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.062
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Methods and Protocols
March 14, 2017
Platform 1
Analysis of ethylene oxide and vinyl chloride in THS aerosol
PMI
-
Methods and Protocols
March 14, 2017
Platform 1
Analysis of 12 polycyclic aromatic hydrocarbons in THS aerosol
PMI
-
Methods and Protocols
August 17, 2016
Platform 1
Procedure for accurately quantify water in mainstream aerosol of THS aerosol using the in situ extraction method
PMI
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Poster
May 2, 2016
Platform 1
Lung Inflammation and Toxicological Assessment in A/J Mice in Response to Chronic Exposure to Mainstream Aerosol from Candidate Modified Risk Tobacco Product and Smoke from Conventional Cigarettes
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, E Veljkovic, AW Hayes, P Leroy, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
May 2, 2016
Platform 1
Xenobiotic Metabolism Responses of Nasal, Oral and Bronchial Organotypic Epithelial Cultures: A Comparison of Tobacco Heating System Aerosol and Combustible Cigarette Smoke
A Iskandar, S Majeed, L Ortega Torres, D Kuehn, S Johne, F Martin, Y Xiang, A Sewer, P Leroy, R Dulize, E Guedj, NV Ivanov, C Mathis, AW Hayes, J Hoeng, M Peitsch
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Poster
March 20, 2015
Sytems toxicological-based assessment of sex-related differences in response to cigarette smoke within an OECD rat inhalation study
U Kogel, A Sewer, G Vuillaume, S Boue, M Talikka, E T Wong, WS Hayes, P Vanscheeuwijck, J Hoeng, M Peitsch
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Poster
March 17, 2017
Modeling controlled deposition of polydisperse aerosol in 3D in-vitro exposure systems
F Lucci, A Kuczaj
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Poster
March 12, 2017
Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Aerosol System
Chris Wynne*, A Teichert, P Brossard, Loyse Felber Medlin , Larissa Sandalic, J Ancerewicz, M Franzon, Murray Laugesen, F Lüdicke
* This author is not affiliated with PMI. -
Poster
March 12, 2017
Nicotine Population Pharmacokinetics in Healthy Adult Smokers
P Brossard, M Marchand*, N Lama, R Weitkunat, H Merdjan*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
March 12, 2017
Intention to use the Tobacco Heating System, associated with variants of a potential product brochure
F Beacher, PP Magnani, A Ramazzotti, R Weitkunat, G Kallischnigg, S Colman*, T Alfieri*
* This author is not affiliated with PMI. -
Poster
February 27, 2018
Platform 1
Comparative effect of a candidate modified risk tobacco product aerosol and cigarette smoke on color stability of enamel, dentin and dental composite resins
F Zanetti, X Zhao, S Majeed, H Malmstrom*, M Peitsch, Y Ren*, J Hoeng
* This author is not affiliated with PMI. -
Poster
February 27, 2018
Prediction of disease-specific death rates by using forecasts of their key predictive ecological indicators
S Djurdjevic, A van der Plas, H Brenner*, G Baker, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 27, 2018
Platform 1
Psychometric evaluation of the mCEQ applied to cigarettes and heat-notburn products in the US and Japan
T Salzberger, S Cano, N Mainy, C Chrea, S Vandyke, C Haziza, R Weitkunat, Jed E Rose PhD*
* This author is not affiliated with PMI. -
Poster
February 26, 2018
Platform 1
Methodology for monitoring adverse event reports for potential modified risk tobacco products: experience at Philip Morris International
J Magnette, N Blanc, M Pietro, L Prieto, F Lüdicke
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Poster
February 26, 2018
Platform 1
Potential Predictors of Intended Use of a Novel Heat-not-burn Tobacco Product
F Beacher, PP Magnani, G Kallischnigg, B Zwisele*, S Colman*, F Lüdicke, A Ramazzotti, R Weitkunat
* This author is not affiliated with PMI. -
Poster
February 26, 2018
Development of a tobacco and nicotine products dependence instrument
C Chrea, T Salzberger, L Abetz-Webb*, E Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
* This author is not affiliated with PMI. -
Poster
February 26, 2018
A multi-center multiregional study on biological and functional changes in healthy adult smokers during one year of continuous smoking abstinence
C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Poster
February 26, 2018
Linguistic validation of the Perceived Risk Instrument (PRI) into French, German, Italian, Japanese, Polish and Russian
C Acquadro*, A Belay*, A Popielnicki*, N Mainy, R Weitkunat, C Chrea
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
February 16, 2018
Platform 1
Determination of eight carbonyl compounds in aerosols trapped in phosphate buffer saline solutions to support in vitro assessment studies
R Buratto, D Correia, M Parel, M Crenna, M Bilger, A Debrick
DOI : 10.1016/j.talanta.2018.02.048
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Peer-Reviewed Publication
February 13, 2018
Platform 1
Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes
D Malińska*, J Szymanski*, P Patalas-Krawczyk*, B Michalska*, A Wojtala*, M Prill*, M Partyka*, K Drabik*, J Walczak*, A Sewer, S Johne, K Luettich, M Peitsch, J Hoeng, J Duszynski*, J Szczepanowska*, M Van der Toorn, M Wieckowski*
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.02.013
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Poster
February 9, 2018
High-content screening-based phenotypic analysis of 3D organotypic bronchial tissues
D Marescotti, D Bovard, M Morelli, K Luettich, S Frentzel, M Peitsch, J Hoeng
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Poster
February 5, 2018
Transcriptomic and metabolic analyses of 35S:S523DNR tobacco plants
L Bovet, J Lu*, JND Battey, RS Lewis, S Goepfert, RE Dewey*
* This author is not affiliated with PMI. -
Presentation
January 18, 2018
Platform 1
Nicotine biosynthesis pathway: beyond tobacco
M Kajikawa*, N Sierro, H Kawaguchi*, N Bakaher, NV Ivanov, T Hashimoto*, T Shoji*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 14, 2017
Platform 1
Systems Biology: Methods and Applications
B Titz, A Knorr, A Sewer, F Martin, NV Ivanov, M Talikka, I Gonzalez-Suarez, M Peitsch, J Hoeng
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Pages 434–480
DOI : 10.1016/B978-0-12-409547-2.12333-9
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Peer-Reviewed Publication
February 5, 2018
Organization of the TC and TE cT-DNA regions in Nicotiana otophora and functional analysis of three diverged TE-6b genes
K Chen*, F Dorlhac de Borne*, N Sierro, NV Ivanov, M Alouia*, S Koechler*, L Otten*
* This author is not affiliated with PMI.DOI : 10.1111/tpj.13853
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Book Chapter
January 3, 2018
Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases 1st Edition
E Veljkovic, W Xia, B Phillips, E T Wong, J Ho, A Oviedo, J Hoeng, M Peitsch
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Peer-Reviewed Publication
December 29, 2017
Platform 1
Accuracy of the Smoking Questionnaire
Z Sponsiello Wang, G de La Bourdonnaye, M David, F Lüdicke, R Weitkunat
Beiträge zur Tabakforschung International/Contributions to Tobacco Research
DOI : 10.1515/cttr-2017-0023
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Peer-Reviewed Publication
December 29, 2017
Platform 1
Determination of Mercury in Aerosol by Inductively Coupled Plasma Mass Spectrometry
I Hofer, M Gremaud, A Marchese, S Le Bouhellec
Beiträge zur Tabakforschung International/Contributions to Tobacco Research
Volume 27, Issue 8, Pages 186–194
DOI : 10.1515/cttr-2017-0020
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Peer-Reviewed Publication
January 9, 2018
Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products
M Peck, EB Sanders, G Scherer*, F Lüdicke, R Weitkunat
* This author is not affiliated with PMI.DOI : 10.1080/1354750X.2017.1419284
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Peer-Reviewed Publication
December 28, 2017
Platform 1
Innovative methodology based on thermo-denuder principle for the detection of combustion related solid particles or high boiling point droplets: Applications to cigarette and the Tobacco Heating System THS 2.2
P Pratte, S Cosandey, C Goujon-Ginglinger
DOI : 10.1016/j.jaerosci.2017.12.011
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Peer-Reviewed Publication
January 2, 2018
Platform 1
Effects of cigarette smoking on color stability of dental resin composites.
X Zhao, F Zanetti, S Majeed, J Pan*, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.American Journal of Dentistry.
30(6):316-322.
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Peer-Reviewed Publication
December 13, 2017
Exploring the microbiome in health and disease: Implications for toxicology
