Peer-Reviewed Publication

December 1, 2019

Platform 1

Platform 4

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

E T Wong, J Szostak, B Titz, T Lee, S K Wong, O Lavrynenko, C Merg, M Corciulo, J Simicevic, M Auberson, D Peric, R Dulize, D Bornand, G Loh, KM Lee*, J Zhang*, J Miller IV, W Schlage, E Guedj, T Schneider, B Phillips, P Leroy, MA Choukrallah, N Sierro, A Buettner*, Y Xiang, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

Organ Toxicity and Mechanisms

DOI : 10.1007/s00204-021-03020-4

Article

Peer-Reviewed Publication

April 22, 2021

Platform 4

Effects of whitening toothpaste and bleaching treatment on resin composite discoloration caused by cigarette smoke and electronic vapor aerosol

X Zhao, F Zanetti, L Wang , H Malmstrom*, S Majeed, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.

American Journal of Dentistry

Peer-Reviewed Publication

April 16, 2021

Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds

D Marescotti, G Lo Sasso, D Guerrera, K Renggli , P A Ruiz Castro, R Piault, V Jaquet, F Moine, K Luettich, S Frentzel, M Peitsch, J Hoeng

Frontiers in Pharmacology

DOI : 10.3389/fphar.2021.639716

Article

April 9, 2021

Nicotine: from plants to people

J Olson , W Aryitey, R Costanzo

Medicinska reč (Medical Word)

Research

February 3, 2021

Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE -/- mouse model

U Kogel, E T Wong, J Szostak, W Teck Tan, P Leroy, F Lucci, B Titz, Y Xiang, T Low, S K Wong, E Guedj, NV Ivanov, W Schlage, M Peitsch, A Kuczaj, P Vanscheeuwijck, J Hoeng

Journal of Applied Toxicology

DOI : 10.1002/jat.4149

Publication

March 15, 2021

Platform 4

A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

K Ashutosh*, U Kogel, M Talikka, C Merg, E Guedj, Y Xiang, A Kondylis, B Titz, NV Ivanov, J Hoeng, M Peitsch, J Allen*, A Gupta *, A Skowronek*, K M Lee*
* This author is not affiliated with PMI.

Toxicology Research and Application

DOI : 10.1177%2F2397847321995875

Peer-Reviewed Publication

March 11, 2021

Platform 1

In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy

W Xia, AR Kolli, K Koshibu, F Martin, A Kondylis, A Kuczaj, W Teck Tan, YS Yeo, G Tan, C Teng, K Woon , T Schneider, M Talikka, B Phillips, P Vanscheeuwijck, M Peitsch, J Hoeng

Journal of Natural Products

DOI : 10.1021/acs.jnatprod.0c01044

Peer-Reviewed Publication

November 12, 2020

Platform 1

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

O Lavrynenko, B Titz, S Dijon, D Dos Santos , C Nury, T Schneider, E Guedj, J Szostak, A Kondylis, B Phillips, K Ekroos*, F Martin, M Peitsch, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.

Life Sciences

DOI : 10.1016/j.lfs.2020.118753

Publication

Peer-Reviewed Publication

January 1, 2021

Platform 1

An interlaboratory in vitro aerosol exposure system reference study

Effect of Switching to the Tobacco Heating System Versus Continued Cigarette Smoking on Chronic Generalized Periodontitis Treatment Outcome: Protocol for a Randomized Controlled Multicenter Study

S Pouly, W Teck Ng, M Benzimra, A Soulan, N Blanc, F Zanetti, P Picavet, G Baker, C Haziza

JMIR Research Protocols

DOI : https://doi.org/10.2196/15350

Book Chapter

Use of qualitative research to ensure we measure what matters to users of tobacco and nicotine products

E. F. Afolalu, E Clerc, L Abetz-Webb*, C Chrea
* This author is not affiliated with PMI.

Coresta CROM Symposium

Presentation

December 10, 2020

A Consortium Approach for Consumer Reported Outcome Measures for Assessing Tobacco and Nicotine-Containing Products

C Chrea

Coresta Crom Symposium

Peer-Reviewed Publication

December 29, 2020

Platform 3

State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

S Boue, D Goedertier, J Hoeng, A Iskandar, A Kuczaj, D Marescotti, C Mathis, A May*, B Phillips, M Peitsch, W Schlage, D Sciuscio, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.

Toxicology Research and Application

DOI : 10.1177/2397847320979751

Peer-Reviewed Publication

November 18, 2020

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

A Giralt, A Iskandar, F Martin, E Moschini*, T Serchi*, A Kondylis, D Marescotti, P Leroy, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, AC Gutleb*, J Hoeng
* This author is not affiliated with PMI.

Toxicology Letters

DOI : 10.1016/j.toxlet.2020.11.006

Peer-Reviewed Publication

November 28, 2020

Multispecies aerosol evolution and deposition in a human respiratory tract cast model

M Asgari, F Lucci, A Kuczaj

Journal of Aerosol Science

DOI : 10.1016/j.jaerosci.2020.105720

Publication

November 5, 2020

Platform 2

Reduced levels of biomarkers of exposure in smokers switching to the Carbon-Heated Tobacco Product 1.0: a controlled, randomized, open-label 5-day exposure trial

CT Tran, M Bosilkovska, G de La Bourdonnaye, N Blanc, C Haziza

Scientific Reports

DOI : 10.1038/s41598-020-76222-y

Publication

Peer-Reviewed Publication

November 1, 2020

Tobacco harm reduction: The potential to reduce the risk from smoking: a six-month exposure response study on switching from cigarettes to tobacco heating system (THS)

C Haziza, R Costanzo, G de La Bourdonnaye

Medicinska reč (Medical World)

Peer-Reviewed Publication

October 29, 2020

Heated Tobacco Products

Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity

A van der Plas, S Pouly, N Blanc, C Haziza, G de La Bourdonnaye, B Titz, J Hoeng, NV Ivanov, BV Taranu, A Heremans

Toxicology Reports

DOI : 10.1016/j.toxrep.2020.10.017

Peer-Reviewed Publication

October 12, 2020

Analysis of waterpipe aerosol constituents in accordance with the ISO standard 22486

G Jaccard, D Tafin Djoko, A Korneliou, M Belushkin

Toxicology Reports

DOI : 10.1016/j.toxrep.2020.10.007

Poster

September 21, 2020

Lung/liver-on-a-chip for systemic toxicity studies

D Bovard, A Sandoz, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng

Open Tox

Poster

October 4, 2020

Heated Tobacco Products

Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit

G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater

European Atherosclerosis Society (EAS) 2020

Poster

October 28, 2020

Development and testing of the Independent Holistic Air-Liquid Aerosol Exposure System (InHALES)

S Steiner, P Herve, S Majeed, C Pak, A Kuczaj, J Hoeng

Forum Finanz und Wirtschaft

Poster

October 19, 2020

Nicotine-Containing E-Vapor Products

Plasma Protein Biomarker Identification for Monitoring Molecular Changes in Smokers, Former Smokers, and E-Vapor Product Users Compared with Never Smokers

C Nury, Y Eb-Levadoux, AR Kolli, C Poussin, TM Curran*, LA Baglia*, RA Berg*, Loyse Felber Medlin , S Ansari, E Kishazi, F Martin, B Titz, P Picavet, NV Ivanov, SL Spinelli*, J Hoeng, M Peitsch
* This author is not affiliated with PMI.

Human Proteome Organization World Congress (HUPO Connect 2020)

Article

Publication

Report

September 24, 2020

Scientific Update September 2020 Issue 11

PMI

Peer-Reviewed Publication

July 15, 2020

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

U Marx*, T. Akabane *, TB Andersson *, E. Baker *, M Beilmann*, S Beken*, S. Brendler-Schwaab*, M Cirit*, R. David *, E-M Dehne*, I. Durieux *, L. Ewart *, SC Fitzpatrick*, O Frey*, F Fuchs *, L Griffith *, G Hamilton *, T Hartung*, J Hoeng, H Hogberg *, DJ Hughes *, DE Ingber *, A Iskandar, T Kanamori *, H Kojima*, J Kuehnl*, M Leist*, B Li *, P Loskill *, DL Mendrick *, T Neumann *, G Pallocca *, I Rusyn *, L Smirnova*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, S Tsyb*, M Trapecar*, BVD Water *, JVD Eijnden-van Raaij*, P Vulto*, K Watanabe*, A Wolf*, X Zhou*, A Roth*
* This author is not affiliated with PMI.

ALTEX

DOI : 10.14573/altex.2001241

Peer-Reviewed Publication

September 25, 2020

Heated Tobacco Products

Robustness of HPHC Reduction for THS 2.2 Aerosol Compared with 3R4F Reference Cigarette Smoke Under High Intensity Puffing Conditions

C Goujon-Ginglinger, S Kleinhans, S Maeder, L Poget, JP Schaller

Beiträge zur Tabakforschung International/Contributions to Tobacco Research

DOI : 10.2478/cttr-2020-0008

Peer-Reviewed Publication

October 6, 2020

Heated Tobacco Products

Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

G Rodrigo, G Jaccard, D Tafin Djoko, A Korneliou, M Esposito, M Belushkin

Archives of Toxicology

DOI : 10.1007/s00204-020-02924-x

Peer-Reviewed Publication

October 4, 2020

Nicotine-Containing E-Vapor Products

Collecting e-cigarette aerosols for in vitro applications: A survey of the biomedical literature and opportunities to increase the value of submerged cell culture-based assessments

D Smart, G Phillips*
* This author is not affiliated with PMI.

W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng

Toxicology Reports

DOI : 10.1016/j.toxrep.2020.09.004

Peer-Reviewed Publication

September 12, 2020

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

A Sewer, F Zanetti, A Iskandar, E Guedj, R Dulize, D Peric, D Bornand, C Mathis, F Martin, NV Ivanov, M Peitsch, J Hoeng

Toxicology Reports

DOI : 10.1016/j.toxrep.2020.09.001

Poster

September 7, 2020

Heated Tobacco Products

Human chemical signature — Investigating the influence of human presence and selected activities on concentrations of airborne constituents

C Goujon-Ginglinger, M Mitova, M Rotach, J.H Kim, S Maeder

4th International Conference on Bioresources, Energy, Environment, and Materials Technology (BEEM 2020)

Peer-Reviewed Publication

September 4, 2020

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

D Bovard, A Giralt, K Trivedi, L Neau, Petros Kanellos , A Iskandar, A Kondylis, K Luettich, S Frentzel, J Hoeng, M Peitsch

Current Research in Toxiocology

DOI : 10.1016/j.crtox.2020.08.002

Poster

August 20, 2019

Heated Tobacco Products

Assessment of the impact of human presence and daily activities on Indoor air quality

M Rotach, M Tharin, N Bielik

Peer-Reviewed Publication

August 24, 2020

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

P A Ruiz Castro, U Kogel, G Lo Sasso, B Phillips, A Sewer, B Titz, L Garcia, A Kondylis, E Guedj, D Peric, D Bornand, R Dulize, C Merg, M Corciulo, NV Ivanov, M Peitsch, J Hoeng

Journal of Inflammation

DOI : 10.1186/s12950-020-00260-6

Peer-Reviewed Publication

Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor

A Susz, P Pratte, C Goujon-Ginglinger

Aerosol and Air Quality Research

DOI : 10.4209/aaqr.2019.11.0604

Report

July 23, 2020

Scientific Update July 2020 Issue 10

PMI

Poster

July 12, 2020

Heated Tobacco Products

Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit

G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch

ISTH 2020 Virtual Congress

Peer-Reviewed Publication

July 14, 2020

Metabolic networks of the Nicotiana genus in the spotlight: content, progress and outlook

H Foerster*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI.

Briefings in Bioinformatics

DOI : 10.1093/bib/bbaa136

Presentation

July 6, 2020

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of liquids and corresponding aerosols

NV Ivanov

Presentation

July 7, 2020

The sbvIMPROVER Metagenomics Diagnostics for Inflammatory Bowel Disease Challenge: Results and lessons learned

L Khachatryan

Peer-Reviewed Publication

July 8, 2020

Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish

R Li*, A. Zupanic*, M Talikka, V Belcastro, S Madan*, J. Dörpinghaus*, C. vom Berg*, J Szostak, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

Chemical Research in Toxicology

DOI : 10.1021/acs.chemrestox.0c00095

Presentation

July 1, 2020

Heated Tobacco Products

Tobacco Heating System in mild to moderate chronic obstructive pulmonary disease subjects: An exploratory analysis

F Sergio

Annual Vietnamese Pulmonary Conference

Presentation

July 1, 2020

Heated Tobacco Products

Effects of cigarette smoking tobacco heating system use and smoking cessation on cough

F Sergio

Annual Vietnamese Pulmonary Conference 2020

Poster

December 10, 2019

3D human microvessel-on-a-chip model for studying monocyte-endothelial adhesion under flow - application in systems toxicology

C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.

International MicroNanoConference 2019

Poster

June 1, 2020

Monitoring of exogenous compound kinetics in exhaled breath

T Zikovic Semren, C Laszlo, M Gomez*, G Vidal-de-Miguel*, J Hoeng, M Peitsch, NV Ivanov, P A. Guy*
* This author is not affiliated with PMI.

Poster

Nicotine-Containing E-Vapor Products

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

MK Reumann*, J Schaefer*, B Titz, RH Aspera-Werz*, E T Wong, J Szostak, V Häussling*, S Ehnert*, P Leroy, W Teck Tan, A Kuczaj, C Audretsch*, F Springer*, A Badke*, P Augat*, L Quentanilla-Fend*, M Martella*, K M Lee*, M Peitsch, J Hoeng, AK Nussler*
* This author is not affiliated with PMI.

Archives of Toxicology

DOI : 10.1007/s00204-020-02769-4

Peer-Reviewed Publication

May 13, 2020

Nicotine-Containing E-Vapor Products

Tracing the composition of single e-cigarette aerosol droplets in situ by laser-trapping and Raman scattering

G David*, E A Parmentier*, I Taurino, R Signorell*
* This author is not affiliated with PMI.

Scientific Reports

DOI : 10.1038/s41598-020-64886-5

Peer-Reviewed Publication

Heated Tobacco Products

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng

Computational and Structural Biotechnology Journal

DOI : 10.1016/j.csbj.2020.04.011

Report

April 2, 2020

Scientific Update April 2020 Issue 9

PMI

Peer-Reviewed Publication

February 18, 2020

Heated Tobacco Products

Nicotine-Containing E-Vapor Products

A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke

J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

American Journal of Physiology - Heart and Circulatory Physiology

DOI : 10.1152/ajpheart.00613.2019

Peer-Reviewed Publication

January 23, 2020

In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures

D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng

SLAS TECHNOLOGY: Translating Life Sciences Innovation

DOI : 10.1177/2472630319895473

Peer-Reviewed Publication

January 21, 2020

Platform 1

O Alijevic, D McHugh, L Rufener*, A Mazurov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.

Phytochemistry

DOI : 10.1016/j.phytochem.2019.112187

Presentation

December 10, 2019

Nicotine-Containing E-Vapor Products

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

NV Ivanov

ENDS US 2019 Conference

Peer-Reviewed Publication

December 20, 2019

Nicotine-Containing E-Vapor Products

Selected Harmful and Potentially Harmful Constituents Levels in Commercial e-Cigarettes

M Belushkin, D Tafin Djoko, M Esposito, A Korneliou, C Jeannet, M Lazzerini, G Jaccard

Chemical Research in Toxicology

DOI : 10.1021/acs.chemrestox.9b00470

Peer-Reviewed Publication

November 29, 2019

Addressing traceability in social measurement: establishing a common metric for dependence

T Salzberger, S Cano, L Abetz-Webb*, E Afolalu, C Chrea, R Weitkunat, K Fagerström*, Jed E Rose PhD*
* This author is not affiliated with PMI.

Journal of Physics: Conference Series

DOI : 10.1088/1742-6596/1379/1/012024

Peer-Reviewed Publication

November 22, 2019

Experimental and computational investigation of a nose-only exposure chamber

F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI.

Aerosol Science and Technology

DOI : 10.1080/02786826.2019.1687843

Report

December 17, 2019

Toxicology Reports

DOI : 10.1016/j.toxrep.2019.11.016

Book Chapter

November 15, 2019

How to build your multiorgan-on-a-chip system: a case study

Organ-on-a-chip

DOI : 10.1016/B978-0-12-817202-5.00015-2

Book Chapter

November 15, 2019

Kidney-on-a-chip

F Zanetti

Organ-on-a-chip

DOI : 10.1016/B978-0-12-817202-5.00007-3

Peer-Reviewed Publication

November 13, 2019

Heated Tobacco Products

Heated Tobacco Products

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

D Sciuscio, J Hoeng, M Peitsch, P Vanscheeuwijck

Inhalation Toxicology

DOI : 10.1080/08958378.2019.1662526

Poster

September 9, 2019

Data sharing and meta-analysis of in vitro toxicology assessment of diverse e-liquid and heat-not-burn platforms on the INTERVALS platform

S Boue, A Stan, J Hoeng, M Peitsch

Peer-Reviewed Publication

September 7, 2019

Nicotine-Containing E-Vapor Products

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng

Archives of Toxicology

DOI : 10.1007/s00204-019-02565-9

Peer-Reviewed Publication

September 3, 2019

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

F Martin, S Gubian, M Talikka, J Hoeng, M Peitsch

BMC Bioinformatics

Peer-Reviewed Publication

August 17, 2019

Platform 4

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations

X Zhao, F Zanetti, L Wang*, J Pan*, S Majeed, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.

Journal of Dentistry

Modeling the Population Years of Life Saved in Japan, Italy, Singapore, And in The U.S. by Introducing a Reduced-Risk Product

S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva

Publication

Peer-Reviewed Publication

June 23, 2019

Performance Evaluation of a Nontargeted Platform Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Integrating Computer-Assisted Structure Identification and Automated Semiquantification for the Comprehensive Chemical Characterization of a Complex Matrix

A Knorr, M Almstetter, E Martin, A Castellon, P Pospisil, M Bentley

Analytical Chemistry

DOI : acs.analchem.9b01659

Poster

July 7, 2019

Journal of Natural Products

DOI : 10.1021/np500725a

Publication

January 1, 2013

Advances in Nicotiana Genetic and “Omics” Resources

JND Battey, N Sierro, N Bakaher, NV Ivanov

Heated Tobacco Products

Favorable Changes in Biomarkers of Potential Harm to Reduce the Adverse Health Effects of Smoking in Smokers Switching to the Menthol Tobacco Heating System 2.2 for Three Months (Part 2)

C Haziza, G de La Bourdonnaye, A Donelli, D Skiada, V Poux, R Weitkunat, G Baker, P Picavet, F Lüdicke

Nicotine & Tobacco Research

DOI : 10.1093/ntr/ntx028

Publication

Peer-Reviewed Publication

July 3, 2019

Heated Tobacco Products

Effects of switching to a heat-not-burn tobacco product on biologically-relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial

F Lüdicke, M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, M Peitsch, R Weitkunat

Cancer Epidemiology, Biomarkers & Prevention

DOI : 10.1158/1055-9965.EPI-18-0915

Infoposter

Poster

July 2, 2019

A lung-on-a-chip platform for improved tissue maturation

D Bovard, A Sandoz, M Morelli, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng

2nd European Organ-on-Chip Conference (EUROoC)

Presentation

June 24, 2019

Advanced in vitro models and approaches for toxicity testing of electronic cigarette aerosol exposure

D Marescotti

24th Interdisciplinary Toxicology Conference (Toxcon)

Publication

Peer-Reviewed Publication

June 22, 2019

Systems toxicology approach to unravel early indicators of squamous cell carcinoma rate in rat nasal epithelium induced by formaldehyde exposure

F Martin, M Talikka, J Hoeng, M Peitsch

International Conference on Practical Applications of Computational Biology & Bioinformatics

DOI : 10.1007/978-3-030-23873-5_3

Poster

June 24, 2019

Prediction models of retention indices: application to gas chromatography coupled to high-resolution mass spectrometry for two column types: DB-624 and HP-5ms

A G Haiduc, E Dossin, P Diana, P Guy, NV Ivanov, M Peitsch

Metabolomics 2019

Poster

June 24, 2019

Untargeted Metabolomics Application to Monitor Urine Samples by Ultra-High-Pressure Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

C Laszlo, A G Haiduc, M. Fatarova, E Dossin, F. de Jong*, C. Beecher*, A. Kamleh*, P Guy, NV Ivanov, M Peitsch
* This author is not affiliated with PMI.

Metabolomics 2019

Publication

Peer-Reviewed Publication

Methods and Protocols

June 12, 2019

Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems

C Mathon, D Bovard, Q Dutertre, S Sendyk, M Bentley, J Hoeng, A Knorr

Metabolomics

DOI : 10.1007/s11306-019-1551-0

Presentation

June 13, 2019

Platform 1

The IQOS Story

G Baker

ISoNTech 2019

Poster

June 14, 2019

Platform 1

Tobacco product use after the launch of a heat-not-burn alternative in Japan: results of two cross-sectional surveys

P Langer, L Prieto, C. Rousseau, A. Formey, D Skiada, E. F. Afolalu, Z Sponsiello Wang, K. Fischer, G Baker, R Weitkunat

GFN 2019

Poster

June 14, 2019

Population Health Impact Model Web Application

S Djurdjevic, F Martin, G Baker, R Weitkunat

GFN 2019

Publication

Poster

June 14, 2019

One year of continuous smoking abstinence: a study on biological and functional changes in healthy adult smokers

Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke

GFN 2019

Poster

May 22, 2019

The development of a new measurement instrument to assess health and functioning among tobacco and nicotine product users: the preparatory phase

E Spies, A Bacso, E Afolalu, L Abetz-Webb*, S Gallot, V Law*, D Floyd*, R Weitkunat, C Chrea
* This author is not affiliated with PMI.

ISPOR 2019

Publication

Peer-Reviewed Publication

March 26, 2019

Heated Tobacco Products

A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)

F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch

Frontiers in Pharmacology

DOI : 10.3389/fphar.2019.00198

Poster

May 8, 2019

Aerosol evolution and deposition in the human upper respiratory tract

M Asgari, F Lucci, J Hoeng, A Kuczaj

RDD Europe 2019

Poster

May 9, 2019

Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen

S Steiner, S Ferreira, M Morelli, A Baldi, A Kuczaj, S Frentzel, M Van der Toorn, M Peitsch, J Hoeng

RDD Europe 2019

Peer-Reviewed Publication

April 11, 2019

Systems toxicology meta-analysis – from aerosol exposure to nanotoxicology

M Talikka, V Belcastro, S Gubian, F Martin, M Peitsch, J Hoeng

Current Opinion in Toxicology

DOI : 10.1016/j.cotox.2019.03.010

Peer-Reviewed Publication

April 27, 2019

Platform 1

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

M Mitova, N Bielik, P B Campelos, C Cluse, C Goujon-Ginglinger, A Jaquier, M G Lueso, S Maeder, C Pitton, L Poget, J Polier-Calame, M Rotach, E G R Rouget, M Schaller, M Tharin, V Zaugg

Air Quality, Atmosphere & Health

DOI : 10.1007/s11869-019-00697-6

Presentation

April 9, 2019

A method for determination of tracheobronchial airway geometries from four different strains of mice

J Hoeng, C Foong, F Lucci, D Yeo, J Chua, A Kuczaj, M Peitsch

EB 2019

Publication

Poster

March 12, 2019

Systems toxicology approach for the assessment of zebrafish neurotoxicity

R Li*, C. vom Berg*, M Talikka, S Madan*, J. Dörpinghaus*, J Szostak, F Martin, M Peitsch, J Hoeng, A. Zupanic*
* This author is not affiliated with PMI.

SOT 2019

Publication

Poster

March 12, 2019

A method for determination of tracheobronchial airway geometries from four different strains of mice

C Foong, M J Oldham*, F Lucci, S. Cockram*, S. Luke*, D Yeo, J Chua, J Hoeng, M Peitsch, A Kuczaj
* This author is not affiliated with PMI.

SOT 2019

Publication

Poster

March 12, 2019

Nicotine-Containing E-Vapor Products

Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment

A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng

SOT 2019

Publication

Poster

March 12, 2019

Nicotine-Containing E-Vapor Products

Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment

A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

SOT 2019

Poster

March 12, 2019

Heated Tobacco Products

Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical

S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch

SOT 2019

Presentation

April 4, 2019

Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

L Bovet, A Hilfiker, JND Battey, N Sierro, S Goepfert

CORESTA AP 2019

Publication

Poster

March 12, 2019

Human multi-organ-chip co-culture approach of bronchial airway and liver models for substance exposure studies

S Frentzel, K Schimek*, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, A Winter*, U Marx*, J Hoeng
* This author is not affiliated with PMI.

PMI

Report

March 28, 2019

Smoke-Free Products – Scientific Update March 2019 Issue 07

PMI

Presentation

March 27, 2019

Assessment of potential neuroprotective effects of alkaloids in a human dopaminergic in vitro model of Parkinson’s disease

MB Fares, C Mathis, A Kondylis, O Alijevic, N Sierro, J Hoeng, M Peitsch

AD/PD 2019

Presentation

March 17, 2019

How human presence and activities of daily living influence indoor air quality

M Mitova, M Tharin, M Rotach, C Goujon-Ginglinger

Pittcon 2019

Report

March 20, 2019

Platform 1

Summary of Evidence of Effects of IQOS on Endothelial function

G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch

Poster

March 16, 2019

Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats

AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng

ASCPT 2019

Peer-Reviewed Publication

Platform 1

Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking

G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck

Cardiovascular Research Meeting 2019

Poster

March 12, 2019

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng

SOT 2019

Poster

March 12, 2019

GladiaTOX: global assessment of dose-response indicators in toxicology

V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng

SOT 2019

Presentation

March 14, 2019

Nicotine-Containing E-Vapor Products

A six-month inhalation study in ApoE -/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

J Szostak

Society of Toxicology (SOT 2019)

Peer-Reviewed Publication

February 27, 2019

Optimization of a Novel In Situ Hybridization Technology on 3D Organotypic Cell Cultures

L Neau, C Lorin, S Frentzel, J Hoeng, A Iskandar, P Leroy, K Trivedi

Applied In Vitro Toxicology

DOI : 10.1089/aivt.2018.0021

Peer-Reviewed Publication

March 5, 2019

Platform 4

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

Internal and Emergency Medicine

DOI : 10.1007/s11739-019-02055-x

Peer-Reviewed Publication

February 25, 2019

Platform 1

Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes

G Jaccard, D Tafin Djoko, A Korneliou, R Stabbert, M Belushkin, M Esposito

Toxicology Reports

DOI : 10.1016/j.toxrep.2019.02.009

Presentation

March 4, 2019

Platform 1

Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Events: Translating Basic Science into Clinical Benefit

C Pater

PreHT, HT & CMS 2019

Presentation

TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
* This author is not affiliated with PMI.

SRNT 2019

Poster

February 21, 2019

Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke

F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch

SRNT 2019

Peer-Reviewed Publication

February 19, 2019

Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT™ Toolbox initiative

C Chrea, C Acquadro*, E. F. Afolalu, E Spies, T Salzberger, L Abetz-Webb*, S Cano, B Arnould*, N Mainy, R Weitkunat
* This author is not affiliated with PMI.

F1000Research

Peer-Reviewed Publication

February 12, 2019

Heated Tobacco Products

A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes

B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2019.02.008

Peer-Reviewed Publication

February 14, 2019

Platform 1

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

J Hoeng, S Maeder, P Vanscheeuwijck, M Peitsch

Internal and Emergency Medicine

Peer-Reviewed Publication

February 15, 2019

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract

H Yepiskoposyan, M Talikka, S Vavassori, F Martin, A Sewer, S Gubian, K Luettich, M Peitsch, J Hoeng

Frontiers in Genetics

DOI : 10.3389/fgene.2019.00087

Peer-Reviewed Publication

February 7, 2019

Platform 1

Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches

MA Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov

Current Opinion in Toxicology

DOI : 10.1016/j.cotox.2019.01.001

Peer-Reviewed Publication

February 12, 2019

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models

D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

ALTEX Alternatives to Animal Experimentation

DOI : 10.14573/altex.1811221

Presentation

February 13, 2019

Platform 1

Harm Reduction in Smokers: Could Chronic Respiratory Disorders be Reduced?

C Haziza, F Sergio

COPD topicalities in family doctor work

Report

February 12, 2019

Platform 1

Response to the article entitled “IQOS: examination of Philip Morris International claim of reduced exposure”

G Baker, C Gubelmann, S Maeder, P Picavet, M Smith, M Peitsch

Presentation

February 8, 2019

Platform 1

Chronic Toxicity and Lung Tumorigenesis in A/J Mice Following Lifetime Exposure to Aerosol from the Tobacco Heating System 2.2 in Comparison with Exposure to 3R4F Reference Cigarette Smoke

K Luettich

APTox Porto

Peer-Reviewed Publication

February 5, 2019

Platform 1

Reduction In Exposure To Selected Harmful And Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence In Smokers Switching To The Menthol Tobacco Heating System 2.2 For Three Months (Part 1)

C Haziza, G de La Bourdonnaye, A Donelli, V Poux, D Skiada, R Weitkunat, G Baker, P Picavet, F Lüdicke

Nicotine & Tobacco Research

DOI : 10.1093/ntr/ntz013

Report

January 22, 2019

Platform 1

Scientific substantiation of the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)

M Nordlund, P Picavet, S Maeder, C Goujon-Ginglinger, M Mitova, M Smith, M Peitsch

Report

January 22, 2019

Platform 1

Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP) as well as the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)

PMI

December 18, 2018

Platform 1

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.

F Zanetti, X Zhao, J Pan*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.

Quintessence International

DOI : 10.3290/j.qi.a41601

Poster

December 17, 2018

Establishing the Vitrocell® Powder Chamber as a particle size-selective platform for in vitro dry powder testing

S Steiner, M Hittinger*, K Knoth*, H Gross*, S Frentzel, A Kuczaj, J Hoeng, T Krebs*, M Peitsch
* This author is not affiliated with PMI.

DDL2018

Report

December 11, 2018

Smoke-Free Products – The Scientific Update December 2018 Issue 06

PMI

Presentation

December 10, 2018

Assessing User Behavior and Risk Perceptions: A Case Study from Philip Morris International

E Spies

ENDS US 2018

Poster

December 10, 2018

Optimization and image analysis of RNAscope ® technology on 3D human organotypic ciliated respiratory epithelial culture

L Neau, K Trivedi, P Leroy, A Iskandar, J Hoeng, S Frentzel

Digital Pathology Congress

Report

December 10, 2018

Platform 1

Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells

G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch

Peer-Reviewed Publication

November 21, 2018

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, K Trivedi, E Guedj, Q Dutertre, M Peitsch, J Hoeng

Lab on a Chip

Lab Chip, 2018,18, 3814-3829

DOI : 10.1039/C8LC01029C

Peer-Reviewed Publication

November 29, 2018

The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production

N Sierro, JND Battey, L Bovet, V Liedschulte, S Ouadi, J Thomas, Hervé Broye, H Laparra, A Vuarnoz, G Lang, S Goepfert, M Peitsch, NV Ivanov

BMC Genomics

DOI : 10.1186/s12864-018-5241-5

Presentation

December 3, 2018

Platform 1

Lung inflammation, emphysema, and lung cancer development in A/J mice in response to chronic exposure to aerosol from a heated tobacco product and cigarette smoke

P Vanscheeuwijck

APSR 2018

Poster

December 3, 2018

Platform 1

Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology

U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch

Swisstox 2018

Peer-Reviewed Publication

November 19, 2018

Influence of smoking on levels of urinary 8-iso Prostaglandin F2α

Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS

G Baker, P Picavet, M Smith, P Vanscheeuwijck, M Peitsch

Presentation

November 16, 2018

Heated Tobacco Products

"Risikoreduzierte“ Tabakprodukte Zukunftsoption des Rauchens?

E Helmle

Berner Augenklinik Ophthalmologie–Symposium

Poster

November 15, 2018

Development of a fit-for-purpose tobacco and nicotine product dependence instrument

C Chrea, T Salzberger, L Abetz-Webb*, E. F. Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
* This author is not affiliated with PMI.

ISPOR 2018

Poster

November 15, 2018

Platform 1

Modeling the population years of life saved by introducing a reduced risk product in the US and in Japan

S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva

ISPOR 2018

Peer-Reviewed Publication

November 12, 2018

BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site

J Gordeeva*, N Morozova*, N Sierro, A Isaev*, T Sinkunas*, K Tsvetkova*, M Matlashov*, L Truncaitė*, RD Morgan*, NV Ivanov, V Siksnys*, L Zeng*, K Severinov*
* This author is not affiliated with PMI.

Nucleic Acids Research

DOI : 10.1093/nar/gky1125

Peer-Reviewed Publication

November 14, 2018

Platform 1

Investigation of menthol content and transfer rates in cigarettes and Tobacco Heating System 2.2

G Jaccard, M Belushkin, C Jeannet, EN Aldilla, AO Wijoyo

Regulatory Toxicology and Pharmacology

DOI : 10.1016/j.yrtph.2018.11.004

Poster

November 14, 2018

Measurement Properties of translated versions of measures assessing the subjective effects of tobacco and nicotine containing products: A literature review

C Acquadro*, C Desvignes-Gleizes*, N Mainy, B Arnould*, E Spies, M Hankins, R Weitkunat, C Chrea
* This author is not affiliated with PMI.

ISPOR 2018

Poster

November 8, 2018

The impact of exposure to cigarette smoke on the secreton of inflammatory mediators: Assessment using human organotypic small airway epithelial cultures from five different donors

C Merg, M Corciulo, A Giralt, A Kondylis, L Ortega Torres, S Majeed, T Schneider, A Iskandar, NV Ivanov, J Hoeng

xMAP Connect

Peer-Reviewed Publication

November 9, 2018

Platform 1

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke

MA Choukrallah, N Sierro, F Martin, K Baumer, J Thomas, S Ouadi, J Hoeng, M Peitsch, NV Ivanov

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.11.020

Presentation

November 12, 2018

Platform 1

TOBACCO HARM REDUCTION: An Overview of PMI’s Scientific Approach & Main Results for the Tobacco Heating System (THS) 2.2, a Candidate Modified Risk Tobacco Product

N Fazenda

46th Maghreb Medical Congress

Peer-Reviewed Publication

October 3, 2018

Embracing Transparency Through Data Sharing

S Boue, M Byrne*, AW Hayes, J Hoeng, M Peitsch
* This author is not affiliated with PMI.

International Journal of Toxicology

DOI : 10.1177/1091581818803880

Presentation

November 7, 2018

How innovation will deliver a smoke-free future

R Minhos

5th Annual Conference of Innovations and Good Practices in the Health Sector

Presentation

November 7, 2018

Development of a Novel In Vitro Aerosol Exposure System: the Independent Holistic Air Liquid Aerosol Exposure System (InHALES)

S Steiner

ECOPA 2018

Poster

October 29, 2018

Heated Tobacco Products

Development of a new outcome measure to assess the impact of reduced-risk tobacco- and nicotine-containing products on health and functioning: a comprehensive literature search

E Spies, L Abetz-Webb*, S Gallot, E. F. Afolalu, C Chrea, R Weitkunat
* This author is not affiliated with PMI.

ISOQOL 2018

Presentation

D Khayat*
* This author is not affiliated with PMI.

Poster

October 19, 2018

Numerical characterization of aerosol exposure systems: an analytical model to predict dose deposition

F Lucci, A Kuczaj

ESTIV 2018

Presentation

October 15, 2018

Platform 1

Modeling the population health impact of introducing a reduced-risk product into the Japan market

S Djurdjevic, K Murakami

24th Annual Meeting of Japan Society for Pharmacoepidemiology 2018

Poster

October 8, 2018

Platform 1

Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking

C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke

Eurothrombosis 2018

Poster

October 5, 2018

Platform 1

Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ

C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

HUPO 2018

Poster

September 6, 2018

Platform 1

Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes

J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

EUROTOX 2018

Presentation

September 27, 2018

Assessment of candidate modified risk tobacco products on oral health in vitro

F Zanetti, J Hoeng

The 11th International Sofia Dental Meeting

Poster

September 27, 2018

Platform 1

Discriminating Spontaneous Tumors from Exposure Induced Tumors in the A/J Mouse Lung Cancer Model

Y Xiang, F Martin, K Luettich, K Trivedi, E Guedj, E T Wong, J Hoeng, M Peitsch

German Conference in Bioinformatics (GCB) 2018

Poster

September 24, 2018

Platform 1

Novel Trapping System for the Quantification of Two Tobacco-Specific Nitrosamines in Indoor Air

M G Lueso, M Schaller, M Mitova, M Rotach, C Goujon-Ginglinger

International Symposium on Chromatography (ISC) 2018

Poster

September 21, 2018

Platform 1

Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke

E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng

X Congresso Franco Brasileiro de Oncologia

Presentation

September 27, 2018

Lung/liver-on-a-chip system

D Bovard

EUSAAT 2018

Poster

September 10, 2018

Characterization of the Aerosol Flow, Sampling, and Deposition in a Nose Only Exposure Chamber

F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI.

IAC 2018

Peer-Reviewed Publication

September 21, 2018

Development and validation of a new instrument to measure perceived risks associated with the use of tobacco and nicotine-containing products

S Cano, C Chrea, T Salzberger, T Alfieri*, G Emilien, N Mainy, A Ramazzotti, F Lüdicke, R Weitkunat
* This author is not affiliated with PMI.

Health and Quality of Life Outcomes

DOI : 10.1186/s12955-018-0997-5

Poster

September 17, 2018

DOI : 10.3390/ijms19092775

Presentation

September 17, 2018

The systems biology verification endeavor – harness the power of the crowd to address computational and biological challenges

S Boue

12th Career Fair in Horizons in Molecular Biology 2018

Poster

September 3, 2018

RPackUtils: R Package Dependencies Manager and Bioconductor & CRAN Mirroring Tool

S Cano, S Gubian

EuroSciPy 2018

Poster

Development of a novel in vitro aerosol exposure system: the Independent Holistic Air Liquid Exposure System (InHALES)

S Steiner, P Hervé, S Majeed, C Pak, A Kuczaj, S Frentzel, J Hoeng

EUROTOX 2018

Peer-Reviewed Publication

August 24, 2018

Platform 1

Evaluation of Biological and Functional Changes in Healthy Smokers Switching to the Tobacco Heating System 2.2 Versus Continued Tobacco Smoking: Protocol for a Randomized, Controlled, Multicenter Study

M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, F Lüdicke

RCTs - Protocols/Proposals (non-eHealth)

D Arndt, C Wachsmuth, C Buchholz, M Bentley

EPA 2018

Poster

August 20, 2018

Agile Implementation of Automated Processes Using the BIOVIA Pipeline Pilot System

E Martin, A Castellon, M Bentley, P Pospisil

IDDST 2018

Presentation

Platform 1

The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study

J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.

NSFA Congress 2018

Book Chapter

June 20, 2018

Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling

A Sewer, M Talikka, F Martin, J Hoeng, M Peitsch

Bioinformatics in the Era of Post Genomics and Big Data

DOI : 10.5772/intechopen.75970

Peer-Reviewed Publication

June 1, 2018

Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

G Lacroix*, W Koch*, D Ritter*, AC Gutleb*, ST Larsen*, T Loret*, F Zanetti, S Constant*, S Chortarea*, B Rothen-Rutishauser*, PS Hiemstra*, E Frejafon*, P Hubert*, L Gribaldo*, P Kearns*, JM Aublant*, S Diabaté*, C Weiss*, A de Groot*, I Kooter*
* This author is not affiliated with PMI.

Applied In Vitro Toxicology

Vol. 4, No. 2

DOI : 10.1089/aivt.2017.0034

Peer-Reviewed Publication

July 17, 2018

Platform 2

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells

C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.07.025

Clinical Study

May 4, 2015

A Multi-center, Multi-region Smoking Cessation Study to Understand the Biological and Functional Changes Related to Smoking Cessation in Healthy Smokers Who Are Continuously Abstinent From Smoking for One Year

PMI

Clinical Study

January 13, 2017

Platform 1

Platform 1

A Single-center, Open-label, Randomized, Controlled, Crossover Study to Explore the Nicotine Pharmacokinetic Profile and Safety of Tobacco Heating System (THS) 2.1 Compared to Conventional Cigarettes Following Single and ad Libitum Use in Smoking, But Otherwise Healthy Subjects.

PMI

Clinical Study

January 31, 2013

Platform 1

A Single-center, Open-label, Randomized, Controlled, 2-arm Parallel Group Study to Evaluate the Exposure to Selected Smoke Constituents in Smoking, But Otherwise Healthy Subjects Switching From Conventional Cigarettes to the Tobacco Heating System (THS) 2.1

PMI

Clinical Study

April 4, 2014

A Multi-center Study to Determine the Levels of Biomarkers of Potential Harm and Biomarkers of Exposure to Cigarette Smoke in Asian Adult Smokers and Non-smokers

PMI

Clinical Study

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

F Lucci, ND Castro*, AA Rostami*, M J Oldham*, J Hoeng, YB Pithawalla*, A Kuczaj
* This author is not affiliated with PMI.

Journal of Aerosol Science

Volume 123, September 2018, Pages 141-160

DOI : 10.1016/j.jaerosci.2018.06.015

Peer-Reviewed Publication

July 9, 2018

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures

S Steiner, P Diana, E Dossin, P Guy, G Vuillaume, A Kondylis, S Majeed, S Frentzel, J Hoeng

Toxicology in Vitro

DOI : 10.1016/j.tiv.2018.06.024

Peer-Reviewed Publication

July 2, 2018

Platform 1

Role of testing standards in smoke-free product assessments

M Belushkin, M Esposito, G Jaccard, C Jeannet, A Korneliou, D Tafin Djoko

Regulatory Toxicology and Pharmacology

Volume 98, October 2018, Pages 1-8

DOI : 10.1016/j.yrtph.2018.06.021

Peer-Reviewed Publication

June 12, 2011

International Journal On Advances in Life Sciences

Int J Adv Life Sci 8: 309-319.

Peer-Reviewed Publication

January 5, 2016

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.

S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI.

Scientific Data

Sci Data 3: 150077.

DOI : 10.1038/sdata.2015.77

Presentation

June 9, 2018

Increasing confidence for compound identification by fragmentation database and in silico fragmentation comparison with LC-HRAM-MS-based non-targeted screening of complex matrices

C Buchholz, D Arndt, C Wachsmuth, M Bentley

66th ASMS Conference on Mass Spectrometry and Allied Topics

Peer-Reviewed Publication

June 20, 2018

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

AJ Clippinger*, D Allen*, HP Behrsing *, KA BéruBé*, MB Bolger*, W Casey*, M DeLorme*, M Gaca*, SC Gehen*, K Glover*, P Hayden*, P Hinderliter*, JA Hotchkiss*, A Iskandar, B Keyser*, K Luettich, L Ma-Hock*, A Maione*, P Makena*, J Melbourne*, L Milchak*, SP Ng*, A Paini*, K Page*, G Patlewicz*, P Prieto*, H Raabe*, EN Reinke*, C Roper*, J Rose*, M Sharma*, W Spoo*, PS Thorne*, DM Wilson*, AM Jarabek*
* This author is not affiliated with PMI.

Toxicology in Vitro

Volume 52, Pages 131–145

DOI : 10.1016/j.tiv.2018.06.009

Peer-Reviewed Publication

June 9, 2018

Modeling the impact of changes in tobacco use on individual disease risks

S Djurdjevic, Z Sponsiello Wang, PN Lee*, JS Fry*, R Weitkunat, F Lüdicke, G Baker
* This author is not affiliated with PMI.

Regulatory Toxicology and Pharmacology

Volume 97, Pages 88-97

DOI : 10.1016/j.yrtph.2018.06.001

Peer-Reviewed Publication

June 22, 2018

Platform 4

Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
* This author is not affiliated with PMI.

Inhalation Toxicology

DOI : 10.1080/08958378.2018.1478916

Peer-Reviewed Publication

June 16, 2018

Platform 1

Investigation and comparison of the transfer of TSNA from tobacco to cigarette mainstream smoke and to the aerosol of a heated tobacco product, THS2.2

G Jaccard, A Kondylis, I Gunduz, J Pijnenburg, M Belushkin

Considerations for comparative tobacco product assessments based on smoke constituent yields

M Belushkin, G Jaccard, A Kondylis

Regulatory Toxicology and Pharmacology

Volume 73, Issue 1, October 2015, Pages 105-113

DOI : 10.1016/j.yrtph.2015.06.017

Peer-Reviewed Publication

February 7, 2014

Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons

BSP Schreiner*, R Lehmann*, U Thiel*, PM Ziemba*, LR Beltrán*, MA Sherkheli*, P Jeanbourquin, A Hugi, M Werner*, G Gisselmann*, H Hatt*
* This author is not affiliated with PMI.

Computer-assisted structure identification (CASI)--an automated platform for high-throughput identification of small molecules by two-dimensional gas chromatography coupled to mass spectrometry.

A Knorr, A Monge, M Stueber, A Stratmann, D Arndt, E Martin, P Pospisil

Limitations of cigarette machine smoking regimens.

E Roemer, RA Carchman*
* This author is not affiliated with PMI.

Z Sponsiello Wang, R Weitkunat, PN Lee*
* This author is not affiliated with PMI.

BMC Cancer

8(1):356

DOI : 10.1186/1471-2407-8-356

Infoposter

June 15, 2018

Platform 1

Platform 1

Changes in Biological and Functional Markers after Six Months, in Three Populations: THS 2.2 (IQOS) Users, Continued Smokers, and Smoking Abstinence

C Haziza

GFN 2018

Peer-Reviewed Publication

June 8, 2018

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility

C Poussin, N Sierro, S Boue, JND Battey, E Scotti, V Belcastro, M Peitsch, NV Ivanov, J Hoeng

PMI

Methods and Protocols

June 7, 2018

Platform 1

Analysis of volatiles and semi-volatiles in Platform 1 Aerosol

PMI

Peer-Reviewed Publication

March 7, 2018

Physiological and biological characterization of smokers with and without COPD.

N Chaudhary, K Luettich, M Peck, E Pierri, Loyse Felber Medlin , G Vuillaume, P Leroy, J Hoeng, M Peitsch

F1000Research

Version 2

DOI : 10.12688/f1000research.11698.2

Report

June 6, 2018

Smoke-Free Products – The Scientific Update June 2018 Issue 05

PMI

Book Chapter

May 23, 2018

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

G Lo Sasso, W Schlage, B Phillips, M Peitsch, J Hoeng

Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy

DOI : 10.5772/intechopen.69569

Poster

May 25, 2018

Enabling Systems Toxicology Assessment Studies with State-of-the-Art Biospecimen Data Management Systems

E Dargaud, S Ansari

ISBER 2018

Peer-Reviewed Publication

May 10, 2018

SolCyc: a database hub at the Sol Genomics Network (SGN) for the manual curation of metabolic networks in Solanum and Nicotiana specific databases

H Foerster*, A Bombarely*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI.

Database: The Journal of Biological Databases and Curation

2018

DOI : 10.1093/database/bay035

Presentation

April 27, 2018

Platform 1

Clinical assessment of products aiming at reducing the risk of use compared with continued cigarette smoking

A Donelli

Poster

Mode-of-action analysis of a positive in vitro micronucleus finding in CHO-WBL cells

D McHugh, P Vanscheeuwijck, FR Helbling, D Smart

GTA 2018

Presentation

May 5, 2018

Nicotine-Containing E-Vapor Products

Mode-of-action analysis of genotoxicity detected by the in vitro micronucleus assay: two industry case studies

D Smart

GTA 2018

Presentation

May 21, 2018

Platform 1

Molecular biomarkers elucidate the role of inflammation and oxidative stress in smoking-related diseases

NV Ivanov

11th International Congress on Autoimmunity

Peer-Reviewed Publication

April 19, 2018

Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B2

A van der Plas, S Pouly, G de La Bourdonnaye, W Teck Ng, G Baker, F Lüdicke

Toxicology Reports

DOI : 10.1016/j.toxrep.2018.04.005

Peer-Reviewed Publication

May 7, 2018

Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science

M Peitsch, R Polosa*, C Proctor*, T Hassler*, M Gaca*, E Hill*, J Hoeng, AW Hayes
* This author is not affiliated with PMI.

Toxicology Research and Application

Volume 2: 1–12

DOI : 10.1177/2397847318773701

Presentation

April 11, 2018

A review of analytical approaches to assess transitions in patterns of tobacco product use in the population

E Afolalu

Coresta SG PUB

Peer-Reviewed Publication

May 16, 2018

Platform 1

Modeling the Population Health Impact of Introducing a Modified Risk Tobacco Product into the U.S. Market

S Djurdjevic, PN Lee*, R Weitkunat, Z Sponsiello Wang, F Lüdicke, G Baker
* This author is not affiliated with PMI.

Healthcare

Analysis of Polylactic acid filters of Marlboro Heatsticks: Response to the article entitled “iQOS: evidence of pyrolysis and release of a toxicant from plastic” by Davis B. et al., 2018

A Glabasnia, P Guy, C Goujon-Ginglinger, S Maeder

Peer-Reviewed Publication

April 11, 2018

Platform 2

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.04.015

Peer-Reviewed Publication

December 14, 2017

Platform 1

Pre-market studies from five countries in Asia and Europe to measure the adoption of the tobacco heating system (THS) in smokers

EM Frederix*, A Kuczaj, M Nordlund, M Belka*, F Lizal*, J Jedelsky*, J Elcner*, M Jicha*, BJ Geurts*
* This author is not affiliated with PMI.

Journal of Aerosol Science

DOI : 10.1016/j.jaerosci.2017.10.007

Peer-Reviewed Publication

March 13, 2018

Platform 2

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment

B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.02.058

Poster

Platform 1

Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome

C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng

Proteomics in Cell Biology and Disease Mechanisms

Peer-Reviewed Publication

March 7, 2018

Platform 1

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product

M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich

Toxicology in Vitro

DOI : 10.1016/j.tiv.2018.02.019

Peer-Reviewed Publication

March 1, 2018

Platform 2

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment

A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.02.063

Peer-Reviewed Publication

March 2, 2018

Platform 2

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens

F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng

Food and Chemical Toxicology

Comparative effect of a candidate modified risk tobacco product aerosol and cigarette smoke on color stability of enamel, dentin and dental composite resins

F Zanetti, X Zhao, S Majeed, H Malmstrom*, M Peitsch, Y Ren*, J Hoeng
* This author is not affiliated with PMI.

SRNT 2018

Poster

Platform 1

Determination of eight carbonyl compounds in aerosols trapped in phosphate buffer saline solutions to support in vitro assessment studies

R Buratto, D Correia, M Parel, M Crenna, M Bilger, A Debrick

Talanta

DOI : 10.1016/j.talanta.2018.02.048

Peer-Reviewed Publication

February 13, 2018

Platform 1

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes

D Malińska*, J Szymanski*, P Patalas-Krawczyk*, B Michalska*, A Wojtala*, M Prill*, M Partyka*, K Drabik*, J Walczak*, A Sewer, S Johne, K Luettich, M Peitsch, J Hoeng, J Duszynski*, J Szczepanowska*, M Van der Toorn, M Wieckowski*
* This author is not affiliated with PMI.

Food and Chemical Toxicology

DOI : 10.1016/j.fct.2018.02.013

Poster

February 9, 2018

High-content screening-based phenotypic analysis of 3D organotypic bronchial tissues

D Marescotti, D Bovard, M Morelli, K Luettich, S Frentzel, M Peitsch, J Hoeng

SLAS 2018

Poster

February 5, 2018

Transcriptomic and metabolic analyses of 35S:S523DNR tobacco plants

L Bovet, J Lu*, JND Battey, RS Lewis, S Goepfert, RE Dewey*
* This author is not affiliated with PMI.

SwissPLANT 2018

Presentation

January 18, 2018

Platform 1

Nicotine biosynthesis pathway: beyond tobacco

Publications

Type

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Platform

December 1, 2019

May 17, 2021

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November 12, 2020

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