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Platform

  • Peer-Reviewed Publication

    January 18, 2021

    Platform 1

    Effect of Switching to the Tobacco Heating System Versus Continued Cigarette Smoking on Chronic Generalized Periodontitis Treatment Outcome: Protocol for a Randomized Controlled Multicenter Study

    S Pouly, W Teck Ng, M Benzimra, A Soulan, N Blanc, F Zanetti, P Picavet, G Baker, C Haziza

    JMIR Research Protocols

    DOI : https://doi.org/10.2196/15350

  • Book Chapter

    January 18, 2021

    Toxicological Evaluation of Electronic Nicotine Delivery Products

    M Peitsch, J Hoeng

    Academic Press

  • Presentation

    November 21, 2020

    Platform 1

    Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit

    G Plebani

    The 7th International Conference on Prehypertension, Hypertension, Metabolic Disorders, and Cardiovascular Disease (PreHT 2020)

  • Presentation

    December 9, 2020

    Platform 3

    Comparative Assessment of Pharmacokinetics and Acute Lung Inflammation of Nicotine Dry Powder Aerosols Generated by PreciseInhale®

    S Lam, R Ng, B Phillips, W Teck Tan, C Teng, C Wong, R Piault, C Merg, D Sciuscio, J Hoeng, P Vanscheeuwijck

    Drug Delivery to the Lungs (DDL) Conference 2020

  • Presentation

    December 10, 2020

    Use of qualitative research to ensure we measure what matters to users of tobacco and nicotine products

    E. F. Afolalu, E Clerc, L Abetz-Webb*, C Chrea
    * This author is not affiliated with PMI.

    Coresta CROM Symposium

  • Presentation

    December 10, 2020

    A Consortium Approach for Consumer Reported Outcome Measures for Assessing Tobacco and Nicotine-Containing Products

    C Chrea

    Coresta Crom Symposium

  • Peer-Reviewed Publication

    December 29, 2020

    Platform 3

    State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

    S Boue, D Goedertier, J Hoeng, A Iskandar, A Kuczaj, D Marescotti, C Mathis, A May*, B Phillips, M Peitsch, W Schlage, D Sciuscio, W Teck Tan, P Vanscheeuwijck
    * This author is not affiliated with PMI.

    Toxicology Research and Application

    DOI : 10.1177/2397847320979751

  • Peer-Reviewed Publication

    November 18, 2020

    Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

    A Giralt, A Iskandar, F Martin, E Moschini*, T Serchi*, A Kondylis, D Marescotti, P Leroy, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, AC Gutleb*, J Hoeng
    * This author is not affiliated with PMI.

    Toxicology Letters

    DOI : 10.1016/j.toxlet.2020.11.006

  • Peer-Reviewed Publication

    November 28, 2020

    Multispecies aerosol evolution and deposition in a human respiratory tract cast model

    M Asgari, F Lucci, A Kuczaj

    Toxicology Letters

    DOI : 10.1016/j.jaerosci.2020.105720

  • Publication

    November 5, 2020

    Platform 2

    Reduced levels of biomarkers of exposure in smokers switching to the Carbon-Heated Tobacco Product 1.0: a controlled, randomized, open-label 5-day exposure trial

    CT Tran, M Bosilkovska, G de La Bourdonnaye, N Blanc, C Haziza

    Scientific Reports

    DOI : 10.1038/s41598-020-76222-y

  • Publication
    Peer-Reviewed Publication

    November 1, 2020

    Tobacco harm reduction: The potential to reduce the risk from smoking: a six-month exposure response study on switching from cigarettes to tobacco heating system (THS)

    C Haziza, R Costanzo, G de La Bourdonnaye

    Medicinska reč (Medical World)

  • Peer-Reviewed Publication

    October 29, 2020

    Heated Tobacco Products

    Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity

    A van der Plas, S Pouly, N Blanc, C Haziza, G de La Bourdonnaye, B Titz, J Hoeng, NV Ivanov, BV Taranu, A Heremans

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2020.10.017

  • Peer-Reviewed Publication

    October 12, 2020

    Analysis of waterpipe aerosol constituents in accordance with the ISO standard 22486

    G Jaccard, D Tafin Djoko, A Korneliou, M Belushkin

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2020.10.007

  • Poster

    September 21, 2020

    Lung/liver-on-a-chip for systemic toxicity studies

    D Bovard, A Sandoz, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng

    Open Tox

  • Poster

    October 4, 2020

    Heated Tobacco Products

    Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit

    G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater

    European Atherosclerosis Society (EAS) 2020

  • Poster

    October 28, 2020

    Development and testing of the Independent Holistic Air-Liquid Aerosol Exposure System (InHALES)

    S Steiner, P Herve, S Majeed, C Pak, A Kuczaj, J Hoeng

    Forum Finanz und Wirtschaft

  • Poster

    October 19, 2020

    Nicotine-Containing E-Vapor Products

    Plasma Protein Biomarker Identification for Monitoring Molecular Changes in Smokers, Former Smokers, and E-Vapor Product Users Compared with Never Smokers

    C Nury, Y Eb-Levadoux, AR Kolli, C Poussin, TM Curran*, LA Baglia*, RA Berg*, Loyse Felber Medlin , S Ansari, E Kishazi, F Martin, B Titz, P Picavet, NV Ivanov, SL Spinelli*, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    Human Proteome Organization World Congress (HUPO Connect 2020)

  • Article
    Publication
    Report

    September 24, 2020

    Scientific Update September 2020 Issue 11

    PMI

  • Peer-Reviewed Publication

    July 15, 2020

    Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

    U Marx*, T. Akabane *, TB Andersson *, E. Baker *, M Beilmann*, S Beken*, S. Brendler-Schwaab*, M Cirit*, R. David *, E-M Dehne*, I. Durieux *, L. Ewart *, SC Fitzpatrick*, O Frey*, F Fuchs *, L Griffith *, G Hamilton *, T Hartung*, J Hoeng, H Hogberg *, DJ Hughes *, DE Ingber *, A Iskandar, T Kanamori *, H Kojima*, J Kuehnl*, M Leist*, B Li *, P Loskill *, DL Mendrick *, T Neumann *, G Pallocca *, I Rusyn *, L Smirnova*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, S Tsyb*, M Trapecar*, BVD Water *, JVD Eijnden-van Raaij*, P Vulto*, K Watanabe*, A Wolf*, X Zhou*, A Roth*
    * This author is not affiliated with PMI.

    ALTEX

    DOI : 10.14573/altex.2001241

  • Peer-Reviewed Publication

    September 25, 2020

    Heated Tobacco Products

    Robustness of HPHC Reduction for THS 2.2 Aerosol Compared with 3R4F Reference Cigarette Smoke Under High Intensity Puffing Conditions

    C Goujon-Ginglinger, S Kleinhans, S Maeder, L Poget, JP Schaller

    Beiträge zur Tabakforschung International/Contributions to Tobacco Research

    DOI : 10.2478/cttr-2020-0008

  • Peer-Reviewed Publication

    October 6, 2020

    Heated Tobacco Products

    Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

    G Rodrigo, G Jaccard, D Tafin Djoko, A Korneliou, M Esposito, M Belushkin

    Archives of Toxicology

    DOI : 10.1007/s00204-020-02924-x

  • Peer-Reviewed Publication

    October 4, 2020

    Nicotine-Containing E-Vapor Products

    Collecting e-cigarette aerosols for in vitro applications: A survey of the biomedical literature and opportunities to increase the value of submerged cell culture-based assessments

    D Smart, G Phillips*
    * This author is not affiliated with PMI.

    Journal of Applied Toxicology

    DOI : 10.1002/jat.4064

  • Poster

    September 7, 2020

    Heated Tobacco Products

    Dos and don’ts in the design of indoor air quality studies on smoke-free products

    C Goujon-Ginglinger, M Mitova, M Rotach, J.H Kim, S Maeder

    4th International Conference on Bioresources, Energy, Environment, and Materials Technology (BEEM 2020)

  • Poster

    September 17, 2020

    Heated Tobacco Products

    Compilation of in vitro studies evaluating the impact of exposure to aerosols from heated tobacco products and an electronic vapor device on oral health and dental esthetics.

    F Zanetti, A Nussbaum, A Iskandar, X Zhao, Y Ren*, S Majeed, NV Ivanov, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    DG PARO

  • Peer-Reviewed Publication

    September 12, 2020

    Heated Tobacco Products

    Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

    W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2020.09.004

  • Peer-Reviewed Publication

    September 12, 2020

    A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

    A Sewer, F Zanetti, A Iskandar, E Guedj, R Dulize, D Peric, D Bornand, C Mathis, F Martin, NV Ivanov, M Peitsch, J Hoeng

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2020.09.001

  • Poster

    September 7, 2020

    Heated Tobacco Products

    Human chemical signature — Investigating the influence of human presence and selected activities on concentrations of airborne constituents

    C Goujon-Ginglinger, M Mitova, M Rotach, J.H Kim, S Maeder

    4th International Conference on Bioresources, Energy, Environment, and Materials Technology (BEEM 2020)

  • Peer-Reviewed Publication

    September 4, 2020

    Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

    D Bovard, A Giralt, K Trivedi, L Neau, Petros Kanellos , A Iskandar, A Kondylis, K Luettich, S Frentzel, J Hoeng, M Peitsch

    Current Research in Toxiocology

    DOI : 10.1016/j.crtox.2020.08.002

  • Poster

    August 20, 2019

    Heated Tobacco Products

    Assessment of the impact of human presence and daily activities on Indoor air quality

    M Rotach, M Tharin, N Bielik

  • Peer-Reviewed Publication

    August 24, 2020

    Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

    P A Ruiz Castro, U Kogel, G Lo Sasso, B Phillips, A Sewer, B Titz, L Garcia, A Kondylis, E Guedj, D Peric, D Bornand, R Dulize, C Merg, M Corciulo, NV Ivanov, M Peitsch, J Hoeng

    Journal of Inflammation

    DOI : 10.1186/s12950-020-00260-6

  • Peer-Reviewed Publication

    August 7, 2020

    Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients

    G Lo Sasso, L Khachatryan, A Kondylis, JND Battey, N Sierro, NA Danilova*, TV Grigoryeva*, MI Markelova*, DR Khusnutdinova*, AV Laikov*, II Salafutdinov*, YD Romanova*, MN Siniagina*, IY Vasiliev*, EA Boulygina*, VV Solovyeva*, EE Garanina*, KV Kitaeva*, KY Ivanov*, DS Chulpanova*, KS Kletenkov*, AR Valeeva*, A Kh Odintsova*, MD Ardatskaya*, RA Abdulkhakov*, NV Ivanov, M Peitsch, J Hoeng, SR Abdulkhakov*
    * This author is not affiliated with PMI.

    Inflammatory Bowel Diseases

    DOI : 10.1093/ibd/izaa188

  • Peer-Reviewed Publication

    August 11, 2020

    Heated Tobacco Products

    Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice

    B Titz, A Sewer, K Luettich, E T Wong, E Guedj, C Nury, T Schneider, Y Xiang, K Trivedi, G Vuillaume, P Leroy, A Buettner*, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch
    * This author is not affiliated with PMI.

    Toxicological Sciences

    DOI : 10.1093/toxsci/kfaa132

  • Peer-Reviewed Publication

    August 11, 2020

    Heated Tobacco Products

    Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke

    E T Wong, K Luettich, S Krishnan, S K Wong, WT Lim, D Yeo, A Buettner*, P Leroy, G Vuillaume, S Boue, J Hoeng, P Vanscheeuwijck, M Peitsch
    * This author is not affiliated with PMI.

    Toxicological Sciences

    DOI : 10.1093/toxsci/kfaa131

  • Peer-Reviewed Publication

    August 20, 2020

    Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor

    A Susz, P Pratte, C Goujon-Ginglinger

    Aerosol and Air Quality Research

    DOI : 10.4209/aaqr.2019.11.0604

  • Report

    July 23, 2020

    Scientific Update July 2020 Issue 10

    PMI

  • Poster

    July 12, 2020

    Heated Tobacco Products

    Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit

    G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch

    ISTH 2020 Virtual Congress

  • Peer-Reviewed Publication

    July 14, 2020

    Metabolic networks of the Nicotiana genus in the spotlight: content, progress and outlook

    H Foerster*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
    * This author is not affiliated with PMI.

    Briefings in Bioinformatics

    DOI : 10.1093/bib/bbaa136

  • Presentation

    July 6, 2020

    Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of liquids and corresponding aerosols

    NV Ivanov

  • Presentation

    July 7, 2020

    The sbvIMPROVER Metagenomics Diagnostics for Inflammatory Bowel Disease Challenge: Results and lessons learned

    L Khachatryan

  • Peer-Reviewed Publication

    July 8, 2020

    Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish

    R Li*, A. Zupanic*, M Talikka, V Belcastro, S Madan*, J. Dörpinghaus*, C. vom Berg*, J Szostak, F Martin, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    Chemical Research in Toxicology

    DOI : 10.1021/acs.chemrestox.0c00095

  • Presentation

    July 1, 2020

    Heated Tobacco Products

    Tobacco Heating System in mild to moderate chronic obstructive pulmonary disease subjects: An exploratory analysis

    F Sergio

    Annual Vietnamese Pulmonary Conference

  • Presentation

    July 1, 2020

    Heated Tobacco Products

    Effects of cigarette smoking tobacco heating system use and smoking cessation on cough

    F Sergio

    Annual Vietnamese Pulmonary Conference 2020

  • Poster

    December 10, 2019

    3D human microvessel-on-a-chip model for studying monocyte-endothelial adhesion under flow - application in systems toxicology

    C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
    * This author is not affiliated with PMI.

    International MicroNanoConference 2019

  • Poster

    June 1, 2020

    Monitoring of exogenous compound kinetics in exhaled breath

    T Zikovic Semren, C Laszlo, M Gomez*, G Vidal-de-Miguel*, J Hoeng, M Peitsch, NV Ivanov, P A. Guy*
    * This author is not affiliated with PMI.

  • Poster

    March 3, 2020

    Nicotine-Containing E-Vapor Products

    A structure-based grouping approach for evaluating the toxicity of e-cigarette flavor ingredients: A 5-week inhalation study in A/J mice

    D Sciuscio, K Ashutosh*, P Leroy, A Nussbaum, K M Lee*, E T Wong, P Vanscheeuwijck, M Peitsch, K Luettich, J Hoeng
    * This author is not affiliated with PMI.

  • Peer-Reviewed Publication

    June 17, 2020

    Heated Tobacco Products

    Workshop Series to Identify, Discuss, and Develop Recommendations for the Optimal Generation and Use of In Vitro Assay Data for Tobacco Product Evaluation: Phase 1 Genotoxicity Assays

    M M Moore*, J Clements*, P Desai*, U Doshi*, M Gaca*, X Guo*, T Hashizume*, K G Jordan*, K M Lee*, R Leverette*, D McHugh, J Miller-Holt*, G Phillips*, H Raabe*, L Recio*, S Roy*, D Smart, L F Stankowski, Jr.*, D Thorne*, E Weber*, R Wieczorek*, K Yoshino*, R Curren*
    * This author is not affiliated with PMI.

    Applied In Vitro Toxicology

    DOI : 10.1089/aivt.2020.0004

  • Peer-Reviewed Publication

    June 24, 2020

    An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes

    L Gijzen*, D Marescotti, E Raineri*, A Nicolas*, HL Lanz*, D Guerrera*, R van Vught*, J Joore*, P Vulto*, M Peitsch, J Hoeng, G Lo Sasso, D Kurek*
    * This author is not affiliated with PMI.

    SLAS Technology

    DOI : 10.1177/2472630320924999

  • Peer-Reviewed Publication

    June 4, 2020

    Heated Tobacco Products

    Estimating the population health impact of recently introduced modified risk tobacco products: a comparison of different approaches

    PN Lee*, D Abrams*, A Bachand*, G Baker, R Black*, O Camacho*, G Curtin*, S Djurdjevic, A Hill*, D Mendez*, R S Muhammad-Kah*, J L Murillo*, R Niaura*, YB Pithawalla*, B Poland*, S Sulsky*, L Wei*, R Weitkunat
    * This author is not affiliated with PMI.

    Nicotine & Tobacco Research

    DOI : 10.1093/ntr/ntaa102

  • Peer-Reviewed Publication

    June 8, 2020

    Alkaloid chemophenetics and transcriptomics of the Nicotiana genus

    K P. Kaminski, L Bovet, H Laparra, G Lang, D De Palo, N Sierro, S Goepfert, NV Ivanov

    Phytochemistry

    DOI : 10.1016/j.phytochem.2020.112424

  • Peer-Reviewed Publication

    June 10, 2020

    Heated Tobacco Products

    Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC–MS deconvolution procedures

    A Haiduc, F Zanetti, X Zhao, W Schlage, M Scherer*, N Pluym*, P Schlenger*, NV Ivanov, S Majeed, J Hoeng, M Peitsch, Y Ren*, P A. Guy*
    * This author is not affiliated with PMI.

    Journal of Chromatography B

    DOI : 10.1016/j.jchromb.2020.122228

  • Peer-Reviewed Publication

    April 27, 2020

    Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence

    A Isaev*, A Drobiazko*, N Sierro, J Gordeeva*, I Yosef*, U Qimron*, NV Ivanov, K Severinov*
    * This author is not affiliated with PMI.

    Nucleic Acids Research

    DOI : 10.1093/nar/gkaa290

  • Peer-Reviewed Publication

    June 5, 2020

    Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES)

    S Steiner, P Herve, C Pak, S Majeed, A Sandoz, A Kuczaj, J Hoeng

    Toxicology in Vitro

    DOI : 10.1016/j.tiv.2020.104909

  • Peer-Reviewed Publication

    May 14, 2020

    Nicotine-Containing E-Vapor Products

    E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

    MK Reumann*, J Schaefer*, B Titz, RH Aspera-Werz*, E T Wong, J Szostak, V Häussling*, S Ehnert*, P Leroy, W Teck Tan, A Kuczaj, C Audretsch*, F Springer*, A Badke*, P Augat*, L Quentanilla-Fend*, M Martella*, K M Lee*, M Peitsch, J Hoeng, AK Nussler*
    * This author is not affiliated with PMI.

    Archives of Toxicology

    DOI : 10.1007/s00204-020-02769-4

  • Peer-Reviewed Publication

    May 13, 2020

    Nicotine-Containing E-Vapor Products

    Tracing the composition of single e-cigarette aerosol droplets in situ by laser-trapping and Raman scattering

    G David*, E A Parmentier*, I Taurino, R Signorell*
    * This author is not affiliated with PMI.

    Scientific Reports

    DOI : 10.1038/s41598-020-64886-5

  • Peer-Reviewed Publication

    May 12, 2020

    Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

    K Schimek*, S Frentzel, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, H Erfurth*, E-M Dehne*, A Winter*, U Marx*, J Hoeng
    * This author is not affiliated with PMI.

    Scientific Reports

    DOI : 10.1038/s41598-020-64219-6

  • Peer-Reviewed Publication

    May 11, 2020

    Platform 1

    Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2

    J Walczak*, D Malińska*, K Drabik*, B Michalska*, M Prill*, S Johne, K Luettich, J Szymanski*, M Peitsch, J Hoeng, J Duszynski*, M Wieckowski*, M Van der Toorn, J Szczepanowska*
    * This author is not affiliated with PMI.

    Cellular Physiology and Biochemistry

    DOI : DOI.ORG/10.33594/000000216

  • Peer-Reviewed Publication

    May 6, 2020

    Heated Tobacco Products

    Exposure to harmful and potentially harmful constituents decreased in smokers switching to Carbon-Heated Tobacco Product

    M Bosilkovska, CT Tran, G de La Bourdonnaye, BV Taranu, M Benzimra, C Haziza

    Toxicology Letters

    DOI : 10.1016/j.toxlet.2020.04.013

  • Peer-Reviewed Publication

    May 5, 2020

    Nicotine-Containing E-Vapor Products

    Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

    J Ho, D Sciuscio, U Kogel, B Titz, P Leroy, G Vuillaume, M Talikka, E Martin, P Pospisil, S Lebrun, W Xia, T Lee, Y X Chng, B Phillips, E Veljkovic, E Guedj, Y Xiang, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck

    Archives of Toxicology

    DOI : 10.1007/s00204-020-02759-6

  • Peer-Reviewed Publication

    April 25, 2020

    Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective

    K Ekroos*, O Lavrynenko, B Titz, C Pater, J Hoeng, NV Ivanov
    * This author is not affiliated with PMI.

    Progress in Lipid Research

    DOI : 10.1016/j.plipres.2020.101030

  • Peer-Reviewed Publication

    April 21, 2020

    Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system

    M J Oldham*, ND Castro*, J Zhang*, F Lucci, P Kosachevsky*, AA Rostami*, I G Gilman*, YB Pithawalla*, A Kuczaj, J Hoeng, K M Lee*
    * This author is not affiliated with PMI.

    Toxicology in Vitro

    DOI : 10.1016/j.tiv.2020.104870

  • Peer-Reviewed Publication

    April 25, 2020

    Heated Tobacco Products

    Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

    B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng

    Computational and Structural Biotechnology Journal

    DOI : 10.1016/j.csbj.2020.04.011

  • Report

    April 2, 2020

    Scientific Update April 2020 Issue 9

    PMI

  • Peer-Reviewed Publication

    February 18, 2020

    Heated Tobacco Products

    Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening

    M Bentley, M Almstetter, D Arndt, A Knorr, E Martin, P Pospisil, S Maeder

    Analytical and Bioanalytical Chemistry

    DOI : 10.1007/s00216-020-02502-1

  • Peer-Reviewed Publication

    February 18, 2020

    Alternatives to Animal Use in Risk Assessment of Mixtures

    AW Hayes, A Muriana*, A Alzualde*, DB Fernandez*, A Iskandar, M Peitsch, A Kuczaj, J Hoeng
    * This author is not affiliated with PMI.

    International Journal of Toxicology

    DOI : 10.1177/1091581820905088

  • Peer-Reviewed Publication

    February 13, 2020

    Anthropometry-based generation of personalized and population-specific human airway models

    R Kannan*, ZJ Chen*, A Przekwas*, P Segars*, F Martin, A Kuczaj, J Hoeng
    * This author is not affiliated with PMI.

    International Journal for Numerical Methods in Biomedical Engineering

    DOI : 10.1002/cnm.3324

  • Peer-Reviewed Publication

    January 24, 2020

    Nicotine-Containing E-Vapor Products

    A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke

    J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    American Journal of Physiology - Heart and Circulatory Physiology

    DOI : 10.1152/ajpheart.00613.2019

  • Peer-Reviewed Publication

    January 23, 2020

    In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures

    D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng

    SLAS TECHNOLOGY: Translating Life Sciences Innovation

    DOI : 10.1177/2472630319895473

  • Peer-Reviewed Publication

    January 21, 2020

    Platform 1

    State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products

    S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
    * This author is not affiliated with PMI.

    Toxicology Research and Application

    DOI : 10.1177/2397847319897869

  • Peer-Reviewed Publication

    September 3, 2019

    A complex matrix characterization approach, applied to cigarette smoke, that integrates multiple analytical methods and compound identification strategies for non‐targeted liquid chromatography with high‐resolution mass spectrometry

    D Arndt, C Wachsmuth, C Buchholz, M Bentley

    Rapid Communications in Mass Spectrometry

    DOI : doi.org/10.1002/rcm.8571

  • Peer-Reviewed Publication

    January 7, 2020

    Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of in Vitro Aerosol Exposure Experiments

    C Frege, M Asgari, S Steiner, S Ferreira, S Majeed, F Lucci, S Frentzel, J Hoeng, A Kuczaj

    Chemical Research in Toxicology

    DOI : doi.org/10.1021/acs.chemrestox.9b00381

  • Peer-Reviewed Publication

    December 27, 2019

    Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro

    D Smart, FR Helbling, M Verardo, A Huber, D McHugh, P Vanscheeuwijck

    Mutation Research/Genetic Toxicology and Environmental Mutagenesis

    DOI : 10.1016/j.mrgentox.2019.503129

  • Peer-Reviewed Publication

    January 6, 2020

    Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond

    AR Kolli, A Kuczaj, F Martin, AW Hayes, M Peitsch, J Hoeng

    Critical Reviews in Toxicology

    DOI : 10.1080/10408444.2019.1692780

  • Peer-Reviewed Publication

    December 21, 2019

    Applying Systems Toxicology Methods to Drug Safety

    M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch

    DOI : 10.1016/B978-0-12-801238-3.11522-3

  • Peer-Reviewed Publication

    December 19, 2019

    An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors

    O Alijevic, D McHugh, L Rufener*, A Mazurov, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    Phytochemistry

    DOI : 10.1016/j.phytochem.2019.112187

  • Presentation

    December 10, 2019

    Nicotine-Containing E-Vapor Products

    Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

    NV Ivanov

    ENDS US 2019 Conference

  • Peer-Reviewed Publication

    December 20, 2019

    Nicotine-Containing E-Vapor Products

    Selected Harmful and Potentially Harmful Constituents Levels in Commercial e-Cigarettes

    M Belushkin, D Tafin Djoko, M Esposito, A Korneliou, C Jeannet, M Lazzerini, G Jaccard

    Chemical Research in Toxicology

    DOI : 10.1021/acs.chemrestox.9b00470

  • Peer-Reviewed Publication

    November 29, 2019

    Addressing traceability in social measurement: establishing a common metric for dependence

    T Salzberger, S Cano, L Abetz-Webb*, E Afolalu, C Chrea, R Weitkunat, K Fagerström*, Jed E Rose PhD*
    * This author is not affiliated with PMI.

    Journal of Physics: Conference Series

    DOI : 10.1088/1742-6596/1379/1/012024

  • Peer-Reviewed Publication

    November 22, 2019

    Experimental and computational investigation of a nose-only exposure chamber

    F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
    * This author is not affiliated with PMI.

    Aerosol Science and Technology

    DOI : 10.1080/02786826.2019.1687843

  • Report

    December 17, 2019

    Smoke-Free Products - Scientific Update December 2019 Issue 8

    PMI

  • Peer-Reviewed Publication

    December 1, 2019

    Nicotine-Containing E-Vapor Products

    Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay

    D Smart, FR Helbling, D McHugh, P Vanscheeuwijck

    Toxicology Research and Application

    DOI : 10.1177/2397847319887904

  • Peer-Reviewed Publication

    December 4, 2019

    Platform 1

    An experimental investigation into the operation of an electrically heated tobacco system

    V Cozzani*, F. *, T McGrath, M. Mahler, M Nordlund, M Smith, JP Schaller, G Zuber
    * This author is not affiliated with PMI.

    Thermochimica Acta

    DOI : 10.1016/j.tca.2019.178475

  • Peer-Reviewed Publication

    November 25, 2019

    Nicotine-Containing E-Vapor Products

    Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

    D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2019.11.016

  • Book Chapter

    November 15, 2019

    How to build your multiorgan-on-a-chip system: a case study

    Organ-on-a-chip

    DOI : 10.1016/B978-0-12-817202-5.00015-2

  • Book Chapter

    November 15, 2019

    Kidney-on-a-chip

    F Zanetti

    Organ-on-a-chip

    DOI : 10.1016/B978-0-12-817202-5.00007-3

  • Peer-Reviewed Publication

    November 13, 2019

    Heated Tobacco Products

    Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

    M Van der Toorn, K Koshibu, W Schlage, S Majeed, P Pospisil, J Hoeng, M Peitsch

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2019.11.008

  • Peer-Reviewed Publication

    November 15, 2019

    Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration

    W Xia, E Veljkovic, K Koshibu, M Peitsch, J Hoeng

    European Journal of Pharmacology

    DOI : 10.1016/j.ejphar.2019.172809

  • Peer-Reviewed Publication

    November 11, 2019

    Asparagine Synthesis During Tobacco Leaf Curing

    L Bovet, C Cheval, A Hilfiker, JND Battey, D Langlet, Hervé Broye, J D Schwaar, P Ozelley, G Lang, N Bakaher, H Laparra, S Goepfert

    Plants

    DOI : 10.3390/plants8110492

  • Peer-Reviewed Publication

    November 6, 2019

    Human chemical signature: Investigation on the influence of human presence and selected activities on concentrations of airborne constituents

    M Mitova, C Cluse, C Goujon-Ginglinger, S Kleinhans, M Rotach, M Tharin

    Environmental Pollution

    DOI : 10.1016/j.envpol.2019.113518

  • Peer-Reviewed Publication

    November 6, 2019

    Heated Tobacco Products

    Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke

    J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    Chemico-Biological Interactions

    DOI : 10.1016/j.cbi.2019.108887

  • Peer-Reviewed Publication

    September 30, 2019

    Using data on snus use in Sweden to compare different modelling approaches to estimate the population health impact of introducing a smoke-free tobacco product

    S Djurdjevic, L Pecze*, R Weitkunat, F Lüdicke, JS Fry*, PN Lee*
    * This author is not affiliated with PMI.

    BMC Public Health

    DOI : 10.21203/rs.2.10935/v3

  • Peer-Reviewed Publication

    October 10, 2019

    Deposition Efficiency and Uniformity of Monodisperse Solid Particle Deposition in the Vitrocell® 24/48 Air-Liquid-Interface in-vitro Exposure System

    M J Oldham*, ND Castro*, J Zhang*, AA Rostami*, F Lucci, YB Pithawalla*, A Kuczaj, I G Gilman*, P Kosachevsky*, J Hoeng, K M Lee*
    * This author is not affiliated with PMI.

    Aerosol Science and Technology

    DOI : 10.1080/02786826.2019.1676877

  • Peer-Reviewed Publication

    August 22, 2019

    Heated Tobacco Products

    3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology

    C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
    * This author is not affiliated with PMI.

    ALTEX

    DOI : 10.14573/altex.1811301

  • Peer-Reviewed Publication

    February 24, 2019

    Heated Tobacco Products

    Potential predictors of adoption of the Tobacco Heating System by U.S. adult smokers: An actual use study [version 1; peer review: 1 approved, 2 approved with reservations]

    S Roulet, C Chrea, Claudia Kanitscheider*, G Kallischnigg, PP Magnani, R Weitkunat
    * This author is not affiliated with PMI.

    F1000Research

    DOI : 10.12688/f1000research.17606.1

  • Peer-Reviewed Publication

    September 10, 2019

    Nicotine-Containing E-Vapor Products

    Lysosomotropic-related limitations of the BALB/c 3T3 cell-based neutral red uptake assay and an alternative testing approach for assessing e-liquid cytotoxicity

    G Cudazzo, D Smart, D McHugh, P Vanscheeuwijck

    Toxicology in Vitro

    DOI : 10.1016/j.tiv.2019.104647

  • Peer-Reviewed Publication

    September 9, 2019

    Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

    D Sciuscio, J Hoeng, M Peitsch, P Vanscheeuwijck

    Inhalation Toxicology

    DOI : 10.1080/08958378.2019.1662526

  • Poster

    September 9, 2019

    Data sharing and meta-analysis of in vitro toxicology assessment of diverse e-liquid and heat-not-burn platforms on the INTERVALS platform

    S Boue, A Stan, J Hoeng, M Peitsch

  • Peer-Reviewed Publication

    September 7, 2019

    Nicotine-Containing E-Vapor Products

    Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

    A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng

    Archives of Toxicology

    DOI : 10.1007/s00204-019-02565-9

  • Peer-Reviewed Publication

    September 3, 2019

    NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

    F Martin, S Gubian, M Talikka, J Hoeng, M Peitsch

    BMC Bioinformatics

  • Peer-Reviewed Publication

    August 17, 2019

    Platform 4

    Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations

    X Zhao, F Zanetti, L Wang*, J Pan*, S Majeed, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
    * This author is not affiliated with PMI.

    Journal of Dentistry

    DOI : 10.1016/j.jdent.2019.103182

  • Poster

    August 26, 2019

    Multispecies aerosol evolution and deposition in the Human Respiratory Tract

    M Asgari, F Lucci, A Kuczaj

  • Poster

    August 27, 2019

    Evaluation of a small whole-body exposure chamber for mice

    W Teck Tan, S Krishnan, B Phillips, A Kuczaj, J Hoeng, P Vanscheeuwijck

  • Poster

    August 19, 2019

    Evaluation of selected portable solutions for the assessment of indoor air quality

    E G R Rouget, C Medan, M Tharin, A Glabasnia, M Mitova, C Goujon-Ginglinger

  • Poster

    May 21, 2019

    Heated Tobacco Products

    Modeling the Population Years of Life Saved in Japan, Italy, Singapore, And in The U.S. by Introducing a Reduced-Risk Product

    S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva

  • Publication
    Peer-Reviewed Publication

    June 23, 2019

    Performance Evaluation of a Nontargeted Platform Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Integrating Computer-Assisted Structure Identification and Automated Semiquantification for the Comprehensive Chemical Characterization of a Complex Matrix

    A Knorr, M Almstetter, E Martin, A Castellon, P Pospisil, M Bentley

    Analytical Chemistry

    DOI : acs.analchem.9b01659

  • Poster

    July 7, 2019

    Downregulation of a putative nitrate transporter (CLC-Nt2) substantially reduces the accumulation of tobacco-specific nitrosamines in air-cured tobaccos

    A Hilfiker, L Bovet, J Lu*, P Campanoni, H Laparra, J D Schwaar, RS Lewis, RE Dewey*, S Goepfert
    * This author is not affiliated with PMI.

  • Peer-Reviewed Publication

    July 3, 2019

    Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties

    S Schorderet Weber, K P. Kaminski, JL Perret*, P Leroy, A Mazurov, M Peitsch, NV Ivanov, J Hoeng
    * This author is not affiliated with PMI.

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2019.110660

  • Peer-Reviewed Publication

    July 11, 2019

    Mode‐of‐action analysis of the effects induced by nicotine in the in vitro micronucleus assay

    D Smart, FR Helbling, M Verardo, D McHugh, P Vanscheeuwijck

    Environmental and Molecular Mutagenesis

    DOI : 10.1002/em.22314

  • Peer-Reviewed Publication

    March 1, 2017

    Impairing both HMA4 homeologs is required for cadmium reduction in tobacco

    V Liedschulte, H Laparra, JND Battey, J D Schwaar, Hervé Broye, R Mark, M Klein, S Goepfert, L Bovet

    Plant, Cell & Environment

    DOI : 10.1111/pce.12870

  • Peer-Reviewed Publication

    June 1, 2017

    Genomic insights into the evolution of the nicotine biosynthesis pathway in tobacco

    M Kajikawa*, N Sierro, H Kawaguchi*, N Bakaher, NV Ivanov, T Hashimoto*, T Shoji*
    * This author is not affiliated with PMI.

    Plant Physiology

    DOI : 10.1104/pp.17.00070

  • Peer-Reviewed Publication

    July 14, 2017

    A model for evolution and regulation of nicotine biosynthesis regulon in tobacco

    M Kajikawa*, N Sierro, T Hashimoto*, T Shoji*
    * This author is not affiliated with PMI.

    Plant Signaling & Behavior

    DOI : 10.1080/15592324.2017.1338225

  • Peer-Reviewed Publication

    July 27, 2017

    Multiple disease resistance loci affect soil-borne disease resistance in tobacco (Nicotiana tabacum L.)

    K Drake-Stowe*, N Bakaher, S Goepfert, B Philippon, R Mark, P Peterson*, RS Lewis
    * This author is not affiliated with PMI.

    Phytopathology

    DOI : 10.1094/PHYTO-03-17-0118-R

  • Peer-Reviewed Publication

    November 17, 2016

    Structured plant metabolomics for the simultaneous exploration of multiple factors

    N Vasilev*, J Boccard*, G Lang, U Grömping*, R Fischer*, S Goepfert, S Rudaz*, S Schillberg*
    * This author is not affiliated with PMI.

    Scientific Reports

    DOI : 10.1038/srep37390

  • Peer-Reviewed Publication

    January 23, 2016

    Expression of a constitutively active nitrate reductase variant in tobacco reduces tobacco-specific nitrosamine accumulation in cured leaves and cigarette smoke

    J Lu*, L Zhang*, RS Lewis, L Bovet, S Goepfert, A M Jack*, J D Crutchfield*, H Ji*, RE Dewey*
    * This author is not affiliated with PMI.

    Plant Biotechnology Journal

    DOI : 10.1111/pbi.12510

  • Peer-Reviewed Publication

    November 1, 2016

    Identification of CYP82E21 as a functional nicotine N-demethylase in tobacco flowers

    V Liedschulte, J D Schwaar, H Laparra, A Vuarnoz, B Philippon, N Bakaher, N Sierro, L Bovet, G Lang, S Goepfert

    Phytochemistry

    DOI : 10.1016/j.phytochem.2016.08.004

  • Peer-Reviewed Publication

    December 19, 2014

    Matrix-bound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in tobacco: Quantification and evidence for an origin from lignin-incorporated alkaloids

    G Lang, A Vuarnoz

    Journal of Natural Products

    DOI : 10.1021/np500725a

  • Publication

    January 1, 2013

    Advances in Nicotiana Genetic and “Omics” Resources

    JND Battey, N Sierro, N Bakaher, NV Ivanov

    Genomics of Plant Genetic Resources Volume 1. Managing, sequencing and mining genetic resources

    pp 511-532

    DOI : 10.1007/978-94-007-7572-5

  • Peer-Reviewed Publication

    May 15, 2013

    Whole genome profiling physical map and ancestral annotation of tobacco Hicks Broadleaf

    N Sierro, J van Oeveren*, M J T van Eijk*, F Martin, K Stormo*, M Peitsch, NV Ivanov
    * This author is not affiliated with PMI.

    The Plant Journal

    DOI : 10.1111/tpj.12247

  • Peer-Reviewed Publication

    August 6, 2013

    Controlled vocabularies for plant anatomical parts optimized for use in data analysis tools and for cross-species studies

    R Meskauskiene*, O Laule*, NV Ivanov, F Martin, M Wyss*, W Gruissem*, Philip Zimmermann*
    * This author is not affiliated with PMI.

    Plant Methods

    DOI : 10.1186/1746-4811-9-33

  • Peer-Reviewed Publication

    June 1, 2012

    Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes

    Christophe Sallaud*, Cécile Giacalone*, Romy Töpfer, S Goepfert, N Bakaher, Sandrine Rösti, Alain Tissier*
    * This author is not affiliated with PMI.

    The Plant Journal

    DOI : 10.1111/j.1365-313X.2012.05068.x

  • Peer-Reviewed Publication

    November 28, 2012

    Design of a tobacco exon array with application to investigate the differential cadmium accumulation property in two tobacco varieties

    F Martin, L Bovet, A Cordier, M Stanke, I Gunduz, M Peitsch, NV Ivanov

    BMC Genomics

    DOI : 10.1186/1471-2164-13-674

  • Peer-Reviewed Publication

    March 21, 2012

    Molecular diversity, population structure, and linkage disequilibrium in a worldwide collection of tobacco (Nicotiana tabacum L.) germplasm

    Agostino Fricano*, N Bakaher, Marcello Del Corvo*, Pietro Piffanelli*, P Donini, Alessandra Stella*, NV Ivanov, Carlo Pozzi
    * This author is not affiliated with PMI.

    BMC Genetics

    DOI : 10.1186/1471-2156-13-18

  • Peer-Reviewed Publication

    July 1, 2011

    A high density genetic map of tobacco (Nicotiana tabacum L.) obtained from large scale microsatellite marker development

    G Bindler, Jörg Plieske*, N Bakaher, I Gunduz, NV Ivanov, R Van Der Hoeven, Martin Ganal*, P Donini
    * This author is not affiliated with PMI.

    Theoretical and Applied Genetics

    DOI : 10.1007/s00122-011-1578-8

  • Peer-Reviewed Publication

    February 1, 2010

    COSII genetic maps of two diploid Nicotiana species provide a detailed picture of synteny with tomato and insights into chromosome evolution in tetraploid N. tabacum

    Feinan Wu*, Nancy T. Eannetta*, Yimin Xu*, Jörg Plieske*, Martin Ganal*, Carlo Pozzi, N Bakaher, Steven D. Tanksley*
    * This author is not affiliated with PMI.

    Theoretical and Applied Genetics

    DOI : 10.1007/s00122-009-1206-z

  • Publication
    Peer-Reviewed Publication

    May 24, 2019

    Heated Tobacco Products

    Favorable Changes in Biomarkers of Potential Harm to Reduce the Adverse Health Effects of Smoking in Smokers Switching to the Menthol Tobacco Heating System 2.2 for Three Months (Part 2)

    C Haziza, G de La Bourdonnaye, A Donelli, D Skiada, V Poux, R Weitkunat, G Baker, P Picavet, F Lüdicke

    Nicotine & Tobacco Research

    DOI : 10.1093/ntr/ntx028

  • Publication
    Peer-Reviewed Publication

    July 3, 2019

    Heated Tobacco Products

    Effects of switching to a heat-not-burn tobacco product on biologically-relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial

    F Lüdicke, M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, M Peitsch, R Weitkunat

    Cancer Epidemiology, Biomarkers & Prevention

    DOI : 10.1158/1055-9965.EPI-18-0915

  • Infoposter
    Poster

    July 2, 2019

    A lung-on-a-chip platform for improved tissue maturation

    D Bovard, A Sandoz, M Morelli, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng

    2nd European Organ-on-Chip Conference (EUROoC)

  • Presentation

    June 24, 2019

    Advanced in vitro models and approaches for toxicity testing of electronic cigarette aerosol exposure

    D Marescotti

    24th Interdisciplinary Toxicology Conference (Toxcon)

  • Publication
    Peer-Reviewed Publication

    June 22, 2019

    Systems toxicology approach to unravel early indicators of squamous cell carcinoma rate in rat nasal epithelium induced by formaldehyde exposure

    F Martin, M Talikka, J Hoeng, M Peitsch

    International Conference on Practical Applications of Computational Biology & Bioinformatics

    DOI : 10.1007/978-3-030-23873-5_3

  • Poster

    June 24, 2019

    Prediction models of retention indices: application to gas chromatography coupled to high-resolution mass spectrometry for two column types: DB-624 and HP-5ms

    A G Haiduc, E Dossin, P Diana, P Guy, NV Ivanov, M Peitsch

    Metabolomics 2019

  • Poster

    June 24, 2019

    Untargeted Metabolomics Application to Monitor Urine Samples by Ultra-High-Pressure Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

    C Laszlo, A G Haiduc, M. Fatarova, E Dossin, F. de Jong*, C. Beecher*, A. Kamleh*, P Guy, NV Ivanov, M Peitsch
    * This author is not affiliated with PMI.

    Metabolomics 2019

  • Publication
    Peer-Reviewed Publication

    June 10, 2019

    Development of a realistic human respiratory tract cast representing physiological thermal conditions

    M Asgari, F Lucci, J Bialek, B Dunan*, G Andreatta*, R Smajda*, S Lani*, N Blondiaux*, S Majeed, S Steiner, JP Schaller, S Frentzel, J Hoeng, A Kuczaj
    * This author is not affiliated with PMI.

    Aerosol Science and Technology

    DOI : 10.1080/02786826.2019.1612839

  • Publication
    Peer-Reviewed Publication

    June 13, 2019

    Mitochondria as a possible target for nicotine action

    D Malińska*, M Wieckowski*, B Michalska*, K Drabik*, M Prill*, P Patalas-Krawczyk*, J Walczak*, J Szymanski*, C Mathis, M Van der Toorn, K Luettich, J Hoeng, M Peitsch, J Duszynski*, J Szczepanowska*
    * This author is not affiliated with PMI.

    Journal of Bioenergetics and Biomembranes

    DOI : 10.1007/s10863-019-09800-z

  • Peer-Reviewed Publication

    June 7, 2019

    Heated Tobacco Products

    Biological and functional changes in healthy adult smokers who are continuously abstinent from smoking for one year: Protocol for a prospective, observational, multicenter cohort study

    CT Tran, Loyse Felber Medlin , N Lama, BV Taranu, W Teck Ng, C Haziza, P Picavet, G Baker, F Lüdicke

    JMIR Research Protocols

    DOI : 10.2196/12138

  • Publication
    Peer-Reviewed Publication
    Methods and Protocols

    June 12, 2019

    Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems

    C Mathon, D Bovard, Q Dutertre, S Sendyk, M Bentley, J Hoeng, A Knorr

    Metabolomics

     

    DOI : 10.1007/s11306-019-1551-0

  • Presentation

    June 13, 2019

    Platform 1

    The IQOS Story

    G Baker

    ISoNTech 2019

  • Poster

    June 14, 2019

    Platform 1

    Tobacco product use after the launch of a heat-not-burn alternative in Japan: results of two cross-sectional surveys

    P Langer, L Prieto, C. Rousseau, A. Formey, D Skiada, E. F. Afolalu, Z Sponsiello Wang, K. Fischer, G Baker, R Weitkunat

    GFN 2019

  • Poster

    June 14, 2019

    Population Health Impact Model Web Application

    S Djurdjevic, F Martin, G Baker, R Weitkunat

    GFN 2019

  • Publication
    Poster

    June 14, 2019

    One year of continuous smoking abstinence: a study on biological and functional changes in healthy adult smokers

    Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke

    GFN 2019

  • Poster

    May 22, 2019

    The development of a new measurement instrument to assess health and functioning among tobacco and nicotine product users: the preparatory phase

    E Spies, A Bacso, E Afolalu, L Abetz-Webb*, S Gallot, V Law*, D Floyd*, R Weitkunat, C Chrea
    * This author is not affiliated with PMI.

    ISPOR 2019

  • Publication
    Peer-Reviewed Publication

    March 26, 2019

    Heated Tobacco Products

    A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)

    F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch

    Frontiers in Pharmacology

    DOI : 10.3389/fphar.2019.00198

  • Poster

    May 8, 2019

    Aerosol evolution and deposition in the human upper respiratory tract

    M Asgari, F Lucci, J Hoeng, A Kuczaj

    RDD Europe 2019

  • Poster

    May 9, 2019

    Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen

    S Steiner, S Ferreira, M Morelli, A Baldi, A Kuczaj, S Frentzel, M Van der Toorn, M Peitsch, J Hoeng

    RDD Europe 2019

  • Peer-Reviewed Publication

    April 11, 2019

    Systems toxicology meta-analysis – from aerosol exposure to nanotoxicology

    M Talikka, V Belcastro, S Gubian, F Martin, M Peitsch, J Hoeng

    Current Opinion in Toxicology

    DOI : 10.1016/j.cotox.2019.03.010

  • Peer-Reviewed Publication

    April 27, 2019

    Platform 1

    Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

    M Mitova, N Bielik, P B Campelos, C Cluse, C Goujon-Ginglinger, A Jaquier, M G Lueso, S Maeder, C Pitton, L Poget, J Polier-Calame, M Rotach, E G R Rouget, M Schaller, M Tharin, V Zaugg

    Air Quality, Atmosphere & Health

    DOI : 10.1007/s11869-019-00697-6

  • Presentation

    April 9, 2019

    A method for determination of tracheobronchial airway geometries from four different strains of mice

    J Hoeng, C Foong, F Lucci, D Yeo, J Chua, A Kuczaj, M Peitsch

    EB 2019

  • Publication
    Poster

    March 12, 2019

    Systems toxicology approach for the assessment of zebrafish neurotoxicity

    R Li*, C. vom Berg*, M Talikka, S Madan*, J. Dörpinghaus*, J Szostak, F Martin, M Peitsch, J Hoeng, A. Zupanic*
    * This author is not affiliated with PMI.

    SOT 2019

  • Publication
    Poster

    March 12, 2019

    A method for determination of tracheobronchial airway geometries from four different strains of mice

    C Foong, M J Oldham*, F Lucci, S. Cockram*, S. Luke*, D Yeo, J Chua, J Hoeng, M Peitsch, A Kuczaj
    * This author is not affiliated with PMI.

    SOT 2019

  • Publication
    Poster

    March 12, 2019

    Nicotine-Containing E-Vapor Products

    Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment

    A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng

    SOT 2019

  • Publication
    Poster

    March 12, 2019

    Nicotine-Containing E-Vapor Products

    Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment

    A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    SOT 2019

  • Poster

    March 12, 2019

    Heated Tobacco Products

    Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical

    S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch

    SOT 2019

  • Presentation

    April 4, 2019

    Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

    L Bovet, A Hilfiker, JND Battey, N Sierro, S Goepfert

    CORESTA AP 2019

  • Publication
    Poster

    March 12, 2019

    Human multi-organ-chip co-culture approach of bronchial airway and liver models for substance exposure studies

    S Frentzel, K Schimek*, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, A Winter*, U Marx*, J Hoeng
    * This author is not affiliated with PMI.

    SOT 2019

  • Clinical Study

    February 12, 2019

    Platform 1

    A controlled, open-label, 3-arm parallel group, multi-center study to evaluate the Abdominal Aortic Aneurysm (AAA) growth rate in adult smoking patients randomized to either cigarette smoking or Platform 1 use and to compare with the AAA growth rate in patients who had stopped smoking

    PMI

  • Clinical Study

    March 22, 2019

    Platform 1

    A randomized, controlled, open-label, 4-arm parallel group study to evaluate the effect of switching from cigarette smoking to the use of Platform 1 in healthy adult current smokers on exercise capacity and trainability

    PMI

  • Methods and Protocols

    March 28, 2019

    Platform 1

    Analysis of mercury in Platform 1 aerosol

    PMI

  • Methods and Protocols

    March 28, 2019

    Platform 1

    Analysis of hydrogen cyanide in Platform 1 aerosol

    PMI

  • Methods and Protocols

    March 28, 2019

    Platform 1

    Analysis of 20 elements in Platform 1 aerosol

    PMI

  • Methods and Protocols

    March 28, 2019

    Platform 1

    Analysis of seven phenolic compounds in THS aerosol

    PMI

  • Methods and Protocols

    March 29, 2019

    Platform 1

    Analysis of nitrogen oxides in THS aerosol

    PMI

  • Report

    March 28, 2019

    Smoke-Free Products – Scientific Update March 2019 Issue 07

    PMI

  • Presentation

    March 27, 2019

    Assessment of potential neuroprotective effects of alkaloids in a human dopaminergic in vitro model of Parkinson’s disease

    MB Fares, C Mathis, A Kondylis, O Alijevic, N Sierro, J Hoeng, M Peitsch

    AD/PD 2019

  • Presentation

    March 17, 2019

    How human presence and activities of daily living influence indoor air quality

    M Mitova, M Tharin, M Rotach, C Goujon-Ginglinger

    Pittcon 2019

  • Report

    March 20, 2019

    Platform 1

    Summary of Evidence of Effects of IQOS on Endothelial function

    G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch

  • Poster

    March 16, 2019

    Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats

    AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng

    ASCPT 2019

  • Peer-Reviewed Publication

    March 18, 2019

    GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology

    V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng

    Bioinformatics

    DOI : 10.1093/bioinformatics/btz187

  • Peer-Reviewed Publication

    March 18, 2019

    Platform 1

    Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

    S Boue, W Schlage, D Page, J Hoeng, M Peitsch

    Regulatory Toxicology and Pharmacology

    DOI : 10.1016/j.yrtph.2019.03.007

  • Peer-Reviewed Publication

    March 18, 2019

    Nicotine-Containing E-Vapor Products

    Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

    KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
    * This author is not affiliated with PMI.

    Inhalation Toxicology

    DOI : 10.1080/08958378.2019.1576807

  • Presentation

    March 16, 2019

    Platform 1

    Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking

    G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck

    Cardiovascular Research Meeting 2019

  • Poster

    March 12, 2019

    Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

    D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng

    SOT 2019

  • Poster

    March 12, 2019

    GladiaTOX: global assessment of dose-response indicators in toxicology

    V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng

    SOT 2019

  • Presentation

    March 14, 2019

    Nicotine-Containing E-Vapor Products

    A six-month inhalation study in ApoE -/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

    J Szostak

    Society of Toxicology (SOT 2019)

  • Peer-Reviewed Publication

    February 27, 2019

    Optimization of a Novel In Situ Hybridization Technology on 3D Organotypic Cell Cultures

    L Neau, C Lorin, S Frentzel, J Hoeng, A Iskandar, P Leroy, K Trivedi

    Applied In Vitro Toxicology

    DOI : 10.1089/aivt.2018.0021

  • Peer-Reviewed Publication

    March 5, 2019

    Platform 4

    A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

    A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    Internal and Emergency Medicine

    DOI : 10.1007/s11739-019-02055-x

  • Peer-Reviewed Publication

    February 25, 2019

    Platform 1

    Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes

    G Jaccard, D Tafin Djoko, A Korneliou, R Stabbert, M Belushkin, M Esposito

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2019.02.009

  • Presentation

    March 4, 2019

    Platform 1

    Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Events: Translating Basic Science into Clinical Benefit

    C Pater

    PreHT, HT & CMS 2019

  • Presentation

    March 4, 2019

    Tabakerhitzer (Heat-not-Burn): Das Potenzial für Harm Reduction

    A Nussbaum

    4th German Pharm-Tox Summit

  • Poster

    February 28, 2019

    Platform 1

    Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke

    K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng

    4th German Pharm-Tox Summit

  • Poster

    February 22, 2019

    Platform 1

    Differences in Perceived Health Risk of Cigarettes and IQOS® by Current Product Use Categories and Intention to Quit: A Cross-Sectional Study in Japan

    E Spies, M Dobrynina, G Kallischnigg, B Zwisele*, C Chrea, L Prieto, P Langer, R Weitkunat
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 1

    Test-Retest Reliability of the Lifestyle Questionnaire: Post-hoc Analysis of a Smoking Cessation Study

    N Mainy, G Kallischnigg, B Zwisele*, W Teck Ng, P Langer, M Hankins, C Haziza, R Weitkunat
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Psychometric Validation of the ABOUT–Dependence : A Fit-for-Purpose Instrument to Assess Global Dependence on Tobacco and Nicotine Products

    C Chrea, T Salzberger, L Abetz-Webb*, E. F. Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 3

    Nicotine Pharmacokinetics and Subjective Effects Following Use of a Novel Nicotine-Containing Powder Product

    M Bosilkovska, S Fredersdorf, J Almodovar, N Lama, BV Taranu, E Pierri, M Radicioni*, J Ancerewicz, C Haziza, F Lüdicke
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 4

    Nicotine Pharmacokinetics and Pharmacodynamic Effects of P4M3 Compared with Subjects’ Own Electronic Cigarette

    S Fredersdorf, M Dobrynina, BV Taranu, A Teichert, J Ancerewicz, C Haziza, F Lüdicke

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 1

    Impact of Switching to a Heat-Not-Burn Tobacco Product on CYP1A2 Activity: A Review of Four Clinical Studies

    A van der Plas, N Blanc, C Haziza, B Titz, BV Taranu, N Ciuria, S Ciprietti, C Witt-Gonzalez, D Ancin, V Riccitelli, I D'Errico, M Pietro, L Prieto, R Weitkunat, NV Ivanov, F Lüdicke

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 1

    Exploring Discriminant Capacity of Urinary CEMA as Combustion Marker in Tobacco Users - A Population Pharmacokinetic Approach

    A Claussen*, A Donelli, W Copalu*, N Lama, R Weitkunat, C Haziza, F Lüdicke
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 2

    Decreased Levels of Biomarkers of Exposure in Smokers Switching to Carbon-Heated Tobacco Product 1.2 compared with those who continued to smoke: A Randomized, Controlled, Open-Label 90-Day Exposure Study

    CT Tran, M Bosilkovska, G de La Bourdonnaye, N Blanc, M Benzimra, J Ancerewicz, C Haziza, F Lüdicke

    SRNT 2019

  • Poster

    February 22, 2019

    Creating a Repository for the Assessment of Tobacco-Related Behavioral Outcomes: A Case Example

    E Clerc, N Mainy, C Perret*, C Acquadro*, P Binggeli, C Chrea
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 1

    Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) Compared with Continued Smoking

    C Pater, C Haziza, A Elamin, M S Ansari, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke

    SRNT 2019

  • Poster

    February 22, 2019

    Platform 1

    Biomarker discovery for nicotine-containing product assessment can be facilitated by INTERVALS, a platform to share and analyze non-clinical and clinical data.

    S Boue, M Talikka, F Martin, C Poussin, NV Ivanov, J Hoeng, M Peitsch

    SRNT 2019

  • Poster

    February 22, 2019

    A Multicenter, Multiregional Study on Biological and Functional Changes in Healthy Adult Smokers During One Year of Continuous Smoking Abstinence

    Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke

    SRNT 2019

  • Poster

    February 18, 2019

    Platform 1

    Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Events: Translating Basic Science into Clinical Benefit

    C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke

    Cardiology Update 2019

  • Poster

    February 22, 2019

    Platform 1

    Sociodemographic Characteristics of “Heat-not-Burn” Product Users Compared with Cigarette Smokers: First-Year Results of a Repeated Cross-Sectional Survey in Japan

    P Langer, E. F. Afolalu, L Prieto, D Skiada, M Dobrynina, Z Sponsiello Wang, G Baker, R Weitkunat, F Lüdicke

    SRNT 2019

  • Poster

    February 21, 2019

    Platform 4

    Interfacial Dynamics of the Model Pulmonary Surfactant in the Presence of Glycerol/Propylene Glycol Mixtures

    TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
    * This author is not affiliated with PMI.

    SRNT 2019

  • Poster

    February 21, 2019

    Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke

    F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch

    SRNT 2019

  • Peer-Reviewed Publication

    February 19, 2019

    Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT™ Toolbox initiative

    C Chrea, C Acquadro*, E. F. Afolalu, E Spies, T Salzberger, L Abetz-Webb*, S Cano, B Arnould*, N Mainy, R Weitkunat
    * This author is not affiliated with PMI.

    F1000Research

  • Peer-Reviewed Publication

    February 12, 2019

    Heated Tobacco Products

    A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes

    B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
    * This author is not affiliated with PMI.

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2019.02.008

  • Peer-Reviewed Publication

    February 14, 2019

    Platform 1

    Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

    J Hoeng, S Maeder, P Vanscheeuwijck, M Peitsch

    Internal and Emergency Medicine

  • Peer-Reviewed Publication

    February 15, 2019

    Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract

    H Yepiskoposyan, M Talikka, S Vavassori, F Martin, A Sewer, S Gubian, K Luettich, M Peitsch, J Hoeng

    Frontiers in Genetics

    DOI : 10.3389/fgene.2019.00087

  • Peer-Reviewed Publication

    February 7, 2019

    Platform 1

    Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches

    MA Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov

    Current Opinion in Toxicology

    DOI : 10.1016/j.cotox.2019.01.001

  • Peer-Reviewed Publication

    February 12, 2019

    How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models

    D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    ALTEX Alternatives to Animal Experimentation

    DOI : 10.14573/altex.1811221

  • Presentation

    February 13, 2019

    Platform 1

    Harm Reduction in Smokers: Could Chronic Respiratory Disorders be Reduced?

    C Haziza, F Sergio

    COPD topicalities in family doctor work

  • Report

    February 12, 2019

    Platform 1

    Response to the article entitled “IQOS: examination of Philip Morris International claim of reduced exposure”

    G Baker, C Gubelmann, S Maeder, P Picavet, M Smith, M Peitsch

  • Presentation

    February 8, 2019

    Platform 1

    Chronic Toxicity and Lung Tumorigenesis in A/J Mice Following Lifetime Exposure to Aerosol from the Tobacco Heating System 2.2 in Comparison with Exposure to 3R4F Reference Cigarette Smoke

    K Luettich

    APTox Porto

  • Peer-Reviewed Publication

    February 5, 2019

    Platform 1

    Reduction In Exposure To Selected Harmful And Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence In Smokers Switching To The Menthol Tobacco Heating System 2.2 For Three Months (Part 1)

    C Haziza, G de La Bourdonnaye, A Donelli, V Poux, D Skiada, R Weitkunat, G Baker, P Picavet, F Lüdicke

    Nicotine & Tobacco Research

    DOI : 10.1093/ntr/ntz013

  • Report

    January 22, 2019

    Platform 1

    Scientific substantiation of the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)

    M Nordlund, P Picavet, S Maeder, C Goujon-Ginglinger, M Mitova, M Smith, M Peitsch

  • Report

    January 22, 2019

    Platform 1

    Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP) as well as the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)

    PMI

  • Report

    January 22, 2019

    Platform 1

    Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP)

    M Nordlund, M Smith, S Maeder, T McGrath, JP Schaller, P Pratte, P Picavet, M Peitsch

  • Peer-Reviewed Publication

    December 10, 2018

    Platform 1

    Household Surveys in the General Population and Web-Based Surveys in IQOS Users Registered at the Philip Morris International IQOS User Database: Protocols on the Use of Tobacco- and Nicotine-Containing Products in Germany, Italy, and the United Kingdom (Greater London), 2018-2020

    Z Sponsiello Wang, P Langer, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke

    JMIR Research Protocols

    DOI : 10.2196/12061

  • Peer-Reviewed Publication

    January 3, 2019

    Platform 1

    New approaches to risk assessment of chemical mixtures.

    AW Hayes, R Li*, J Hoeng, A Iskandar, M Peitsch, ML Dourson*
    * This author is not affiliated with PMI.

    Toxicology Research and Application

    3: 2397847318820768

  • Peer-Reviewed Publication

    January 2, 2019

    Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.

    F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.12.056

  • Peer-Reviewed Publication

    December 12, 2018

    Multispecies aerosol evolution and deposition in a bent pipe.

    M Asgari, F Lucci, A Kuczaj

    Journal of Aerosol Science

    Journal of Aerosol Science 129: 53-70.

    DOI : 10.1016/j.jaerosci.2018.12.007

  • Peer-Reviewed Publication

    December 18, 2018

    Platform 1

    Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.

    F Zanetti, X Zhao, J Pan*, M Peitsch, J Hoeng, Y Ren*
    * This author is not affiliated with PMI.

    Quintessence International

    DOI : 10.3290/j.qi.a41601

  • Poster

    December 17, 2018

    Establishing the Vitrocell® Powder Chamber as a particle size-selective platform for in vitro dry powder testing

    S Steiner, M Hittinger*, K Knoth*, H Gross*, S Frentzel, A Kuczaj, J Hoeng, T Krebs*, M Peitsch
    * This author is not affiliated with PMI.

    DDL2018

  • Report

    December 11, 2018

    Smoke-Free Products – The Scientific Update December 2018 Issue 06

    PMI

  • Presentation

    December 10, 2018

    Assessing User Behavior and Risk Perceptions: A Case Study from Philip Morris International

    E Spies

    ENDS US 2018

  • Poster

    December 10, 2018

    Optimization and image analysis of RNAscope ® technology on 3D human organotypic ciliated respiratory epithelial culture

    L Neau, K Trivedi, P Leroy, A Iskandar, J Hoeng, S Frentzel

    Digital Pathology Congress

  • Report

    December 10, 2018

    Platform 1

    Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells

    G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch

  • Peer-Reviewed Publication

    November 21, 2018

    A lung/liver-on-a-chip platform for acute and chronic toxicity studies

    D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, K Trivedi, E Guedj, Q Dutertre, M Peitsch, J Hoeng

    Lab on a Chip

    Lab Chip, 2018,18, 3814-3829 

    DOI : 10.1039/C8LC01029C

  • Peer-Reviewed Publication

    November 29, 2018

    The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production

    N Sierro, JND Battey, L Bovet, V Liedschulte, S Ouadi, J Thomas, Hervé Broye, H Laparra, A Vuarnoz, G Lang, S Goepfert, M Peitsch, NV Ivanov

    BMC Genomics

    DOI : 10.1186/s12864-018-5241-5

  • Presentation

    December 3, 2018

    Platform 1

    Lung inflammation, emphysema, and lung cancer development in A/J mice in response to chronic exposure to aerosol from a heated tobacco product and cigarette smoke

    P Vanscheeuwijck

    APSR 2018

  • Poster

    December 3, 2018

    Platform 1

    Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology

    U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch

    Swisstox 2018

  • Peer-Reviewed Publication

    November 19, 2018

    Influence of smoking on levels of urinary 8-iso Prostaglandin F2α

    A van der Plas, S Pouly, G de La Bourdonnaye, G Baker, F Lüdicke

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2018.11.011

  • Presentation

    November 26, 2018

    Heated Tobacco Products

    Tobacco Harm Reduction & Reduced Risk Products

    R Minhos

    4th Jubilee Congress of General Medicine

  • Presentation

    November 26, 2018

    Platform 1

    Assessment of candidate modified risk tobacco products on oral health in vitro

    E Veljkovic, F Zanetti

    15th Symposium of Oral Surgeons and Implantology

  • Presentation

    November 16, 2018

    Heated Tobacco Products

    Methods for Tobacco Harm Reduction: Introducing the Scientific Assessment Program of PMI Science

    A Nussbaum

    Clinical Operations in Oncology Trials Europe 2018

  • Presentation

    November 15, 2018

    Heated Tobacco Products

    Uncovering Recent ENDS Scientific Research Data

    A Nussbaum

    Next Generation Nicotine Delivery 2018

  • Presentation

    November 19, 2018

    Platform 1

    Respiratory Effects Observed When Using the Tobacco Heating System (THS) Compared with Continued Smoking

    P Picavet

    InSpiro Foundation Meeting of Pulmonary Specialists

  • Report

    November 20, 2018

    Platform 1

    Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS

    G Baker, P Picavet, M Smith, P Vanscheeuwijck, M Peitsch

  • Presentation

    November 16, 2018

    Heated Tobacco Products

    "Risikoreduzierte“ Tabakprodukte Zukunftsoption des Rauchens?

    E Helmle

    Berner Augenklinik Ophthalmologie–Symposium

  • Poster

    November 15, 2018

    Development of a fit-for-purpose tobacco and nicotine product dependence instrument

    C Chrea, T Salzberger, L Abetz-Webb*, E. F. Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
    * This author is not affiliated with PMI.

    ISPOR 2018

  • Poster

    November 15, 2018

    Platform 1

    Modeling the population years of life saved by introducing a reduced risk product in the US and in Japan

    S Djurdjevic, R Weitkunat, G Baker, F Lüdicke, NM Silva

    ISPOR 2018

  • Peer-Reviewed Publication

    November 12, 2018

    BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site

    J Gordeeva*, N Morozova*, N Sierro, A Isaev*, T Sinkunas*, K Tsvetkova*, M Matlashov*, L Truncaitė*, RD Morgan*, NV Ivanov, V Siksnys*, L Zeng*, K Severinov*
    * This author is not affiliated with PMI.

    Nucleic Acids Research

    DOI : 10.1093/nar/gky1125

  • Peer-Reviewed Publication

    November 14, 2018

    Platform 1

    Investigation of menthol content and transfer rates in cigarettes and Tobacco Heating System 2.2

    G Jaccard, M Belushkin, C Jeannet, EN Aldilla, AO Wijoyo

    Regulatory Toxicology and Pharmacology

    DOI : 10.1016/j.yrtph.2018.11.004

  • Poster

    November 14, 2018

    Measurement Properties of translated versions of measures assessing the subjective effects of tobacco and nicotine containing products: A literature review

    C Acquadro*, C Desvignes-Gleizes*, N Mainy, B Arnould*, E Spies, M Hankins, R Weitkunat, C Chrea
    * This author is not affiliated with PMI.

    ISPOR 2018

  • Poster

    November 8, 2018

    The impact of exposure to cigarette smoke on the secreton of inflammatory mediators: Assessment using human organotypic small airway epithelial cultures from five different donors

    C Merg, M Corciulo, A Giralt, A Kondylis, L Ortega Torres, S Majeed, T Schneider, A Iskandar, NV Ivanov, J Hoeng

    xMAP Connect

  • Peer-Reviewed Publication

    November 9, 2018

    Platform 1

    Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke

    MA Choukrallah, N Sierro, F Martin, K Baumer, J Thomas, S Ouadi, J Hoeng, M Peitsch, NV Ivanov

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.11.020

  • Presentation

    November 12, 2018

    Platform 1

    TOBACCO HARM REDUCTION: An Overview of PMI’s Scientific Approach & Main Results for the Tobacco Heating System (THS) 2.2, a Candidate Modified Risk Tobacco Product

    N Fazenda

    46th Maghreb Medical Congress

  • Peer-Reviewed Publication

    October 3, 2018

    Embracing Transparency Through Data Sharing

    S Boue, M Byrne*, AW Hayes, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    International Journal of Toxicology

    DOI : 10.1177/1091581818803880

  • Presentation

    November 7, 2018

    How innovation will deliver a smoke-free future

    R Minhos

    5th Annual Conference of Innovations and Good Practices in the Health Sector

  • Presentation

    November 7, 2018

    Development of a Novel In Vitro Aerosol Exposure System: the Independent Holistic Air Liquid Aerosol Exposure System (InHALES)

    S Steiner

    ECOPA 2018

  • Poster

    October 29, 2018

    Heated Tobacco Products

    Development of a new outcome measure to assess the impact of reduced-risk tobacco- and nicotine-containing products on health and functioning: a comprehensive literature search

    E Spies, L Abetz-Webb*, S Gallot, E. F. Afolalu, C Chrea, R Weitkunat
    * This author is not affiliated with PMI.

    ISOQOL 2018

  • Presentation

    October 29, 2018

    Alternatives to cytotoxicity assessment of eliquids using the neutral red uptake assay

    D McHugh, G Cudazzo, P Vanscheeuwijck

    CORESTA 2018

  • Poster

    October 29, 2018

    Platform 1

    Patterns of Use Behaviors in a Sample of Japanese "Heat-Not-Burn" Tobacco Product (IQOS®) Users

    E. F. Afolalu, P Langer, L Prieto, D Skiada, M Dobrynina, Z Sponsiello Wang, R Weitkunat, F Lüdicke

    CORESTA 2018

  • Poster

    October 29, 2018

    Platform 1

    Cross-Sectional Surveys on the Use of Tobacco Products in the General Population and in Users of IQOS in Germany, Italy, and London (2018-2020): Introducing the Study Protocols

    Z Sponsiello Wang, P Langer, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke

    CORESTA 2018

  • Peer-Reviewed Publication

    October 17, 2018

    Platform 1

    Development and validation of a method for quantification of two tobacco-specific nitrosamines in indoor air

    M G Lueso, M Mitova, N Mottier, M Schaller, M Rotach, C Goujon-Ginglinger

    Journal of Chromatography A

    DOI : 10.1016/j.chroma.2018.10.037

  • Peer-Reviewed Publication

    October 20, 2018

    Platform 1

    Estimating the population health impact of introducing a reduced-risk tobacco product into Japan. The effect of differing assumptions, and some comparisons with the U.S.

    PN Lee*, S Djurdjevic, R Weitkunat, G Baker
    * This author is not affiliated with PMI.

    Regulatory Toxicology and Pharmacology

     

    DOI : 10.1016/j.yrtph.2018.10.010

  • Presentation

    September 1, 2018

    Platform 1

    Smoking and Non-Communicable Diseases in Hong Kong

    D Khayat*
    * This author is not affiliated with PMI.

  • Presentation

    August 30, 2018

    Platform 1

    Cancer and its Causes in Korea

    D Khayat*
    * This author is not affiliated with PMI.

  • Poster

    October 19, 2018

    Numerical characterization of aerosol exposure systems: an analytical model to predict dose deposition

    F Lucci, A Kuczaj

    ESTIV 2018

  • Presentation

    October 15, 2018

    Platform 1

    Modeling the population health impact of introducing a reduced-risk product into the Japan market

    S Djurdjevic, K Murakami

    24th Annual Meeting of Japan Society for Pharmacoepidemiology 2018

  • Poster

    October 8, 2018

    Platform 1

    Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking

    C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke

    Eurothrombosis 2018

  • Poster

    October 5, 2018

    Platform 1

    Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ

    C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    HUPO 2018

  • Poster

    September 6, 2018

    Platform 1

    Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes

    J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    EUROTOX 2018

  • Presentation

    September 27, 2018

    Assessment of candidate modified risk tobacco products on oral health in vitro

    F Zanetti, J Hoeng

    The 11th International Sofia Dental Meeting

  • Poster

    September 27, 2018

    Platform 1

    Discriminating Spontaneous Tumors from Exposure Induced Tumors in the A/J Mouse Lung Cancer Model

    Y Xiang, F Martin, K Luettich, K Trivedi, E Guedj, E T Wong, J Hoeng, M Peitsch

    German Conference in Bioinformatics (GCB) 2018

  • Poster

    September 24, 2018

    Platform 1

    Novel Trapping System for the Quantification of Two Tobacco-Specific Nitrosamines in Indoor Air

    M G Lueso, M Schaller, M Mitova, M Rotach, C Goujon-Ginglinger

    International Symposium on Chromatography (ISC) 2018

  • Poster

    September 21, 2018

    Platform 1

    Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke

    E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng

    X Congresso Franco Brasileiro de Oncologia

  • Presentation

    September 27, 2018

    Lung/liver-on-a-chip system

    D Bovard

    EUSAAT 2018

  • Poster

    September 10, 2018

    Characterization of the Aerosol Flow, Sampling, and Deposition in a Nose Only Exposure Chamber

    F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
    * This author is not affiliated with PMI.

    IAC 2018

  • Peer-Reviewed Publication

    September 21, 2018

    Development and validation of a new instrument to measure perceived risks associated with the use of tobacco and nicotine-containing products

    S Cano, C Chrea, T Salzberger, T Alfieri*, G Emilien, N Mainy, A Ramazzotti, F Lüdicke, R Weitkunat
    * This author is not affiliated with PMI.

    Health and Quality of Life Outcomes

    DOI : 10.1186/s12955-018-0997-5

  • Poster

    September 17, 2018

    Platform 1

    Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking

    G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck

    SBC 2018

  • Poster

    September 10, 2018

    Enabling Systems Toxicology Assessment Studies with State-of-the-Art Biospecimen Information Management Systems

    E Dargaud, S Ansari

    EBW 2018

  • Poster

    September 10, 2018

    Fourier Transformed Infrared (FTIR) Method For Continuous Real-Time Aerosol Characterization For In Vivo Studies

    W Teck Tan, AS Krishnan *, P Vanscheeuwijck
    * This author is not affiliated with PMI.

    IAC 2018

  • Presentation

    September 10, 2018

    Numerical Model for the Aerosol Formation Process in an Electrically Heated Tobacco Product

    M Nordlund

    IAC 2018

  • Presentation

    September 10, 2018

    A novel method for multi-component continuous real-time aerosol monitoring using Fourier Transformed Infrared (FTIR) spectroscopy for in vivo studies

    W Teck Tan, AS Krishnan *, P Vanscheeuwijck
    * This author is not affiliated with PMI.

    IAC 2018

  • Peer-Reviewed Publication

    September 15, 2018

    Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

    B Titz, RM Gadaleta, G Lo Sasso, A Elamin, K Ekroos*, NV Ivanov, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    International Journal of Molecular Sciences

    2018, 19, 2775

    DOI : 10.3390/ijms19092775

  • Presentation

    September 17, 2018

    The systems biology verification endeavor – harness the power of the crowd to address computational and biological challenges

    S Boue

    12th Career Fair in Horizons in Molecular Biology 2018

  • Poster

    September 3, 2018

    RPackUtils: R Package Dependencies Manager and Bioconductor & CRAN Mirroring Tool

    S Cano, S Gubian

    EuroSciPy 2018

  • Poster

    September 7, 2018

    Characterization of a lung-liver organ-on-a-chip model

    D Bovard, A Sandoz, M Morelli, D Marescotti, K Trivedi, K Luettich, S Frentzel, J Hoeng

    EUROTOX 2018

  • Poster

    September 7, 2018

    Platform 4

    Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells

    D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng

    EUROTOX 2018

  • Poster

    September 7, 2018

    Platform 2

    Sharing in INTERVALS study details and data from the assessment of the impact of aerosol from the Carbon-Heated Tobacco Product (CHTP) 1.2, a potential modified risk tobacco product, on human organotypic gingival cultures.

    S Boue, F Zanetti, J Hoeng, M Peitsch

    EUROTOX 2018

  • Poster

    September 7, 2018

    Development of a novel in vitro aerosol exposure system: the Independent Holistic Air Liquid Exposure System (InHALES)

    S Steiner, P Hervé, S Majeed, C Pak, A Kuczaj, S Frentzel, J Hoeng

    EUROTOX 2018

  • Peer-Reviewed Publication

    August 24, 2018

    Platform 1

    Evaluation of Biological and Functional Changes in Healthy Smokers Switching to the Tobacco Heating System 2.2 Versus Continued Tobacco Smoking: Protocol for a Randomized, Controlled, Multicenter Study

    M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, F Lüdicke

    RCTs - Protocols/Proposals (non-eHealth)

    Vol 7, No 8 (2018): August

    DOI : 10.2196/11294

  • Poster

    August 16, 2018

    Platform 1

    Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry

    A Knorr, E Martin, M Almstetter, A Castellon, P Pospisil, M Bentley

    EPA 2018

  • Publication

    August 16, 2018

    Platform 1

    Non-targeted screening using GC×GC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product

    M Almstetter, A Knorr, M Rhouma, E Martin, A Castellon, P Pospisil, M Bentley

    EPA 2018

  • Poster

    August 16, 2018

    Platform 1

    In-depth characterization of chemical differences between heat-not-burn tobacco products and cigarettes using LC-HRAM-MS-based non-targeted differential screening (NTDS)

    D Arndt, C Wachsmuth, C Buchholz, M Bentley

    EPA 2018

  • Poster

    August 20, 2018

    Agile Implementation of Automated Processes Using the BIOVIA Pipeline Pilot System

    E Martin, A Castellon, M Bentley, P Pospisil

    IDDST 2018

  • Presentation

    August 20, 2018

    Building an Efficient R&D Chemo-Centric Data Repository System that Leads to Knowledge Discovery

    P Pospisil, E Martin, A Castellon, M Bentley

    IDDST 2018

  • Presentation

    July 9, 2018

    sbv IMPROVER: Systems Biology Verification combined with Industrial Methodology for Process Verification in Research

    J Hoeng, C Poussin

    ISMB 2018

  • Data

    April 10, 2018

    Platform 1

    90-day OECD rat inhalation study with THS 2.2 (TG413 guideline)

    PMI

    INTERVALS

  • Poster

    July 9, 2018

    Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge

    C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
    * This author is not affiliated with PMI.

    ISMB 2018

  • Poster

    July 30, 2018

    Platform 1

    Air quality assessment during indoor use of the Tobacco Heating System THS 2.2

    C Goujon-Ginglinger, M Mitova, S Maeder, P Pratte, M Rotach

    INDOOR AIR 2018

  • Poster

    June 8, 2018

    Comprehensive chemical characterization of complex matrices through integration of multiple analytical modes and databases for LC-HRAMMS-based non-targeted screening

    C Wachsmuth, D Arndt, E Martin, C Buchholz, M Bentley

    66th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics

  • Poster

    June 8, 2018

    Platform 1

    In-depth characterization of chemical differences between heat-not-burn tobacco products and cigarettes using LC-HRAMMS-based non-targeted differential screening (NTDS)

    D Arndt, C Wachsmuth, C Buchholz, M Bentley

    66th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics

  • Poster

    July 20, 2018

    Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

    L Bovet, A Lenglet, JND Battey, S Goepfert

    ASPB 2018

  • Poster

    June 25, 2018

    Platform 1

    The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study

    J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    NSFA Congress 2018

  • Book Chapter

    June 20, 2018

    Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling

    A Sewer, M Talikka, F Martin, J Hoeng, M Peitsch

    Bioinformatics in the Era of Post Genomics and Big Data

    DOI : 10.5772/intechopen.75970

  • Peer-Reviewed Publication

    June 1, 2018

    Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

    G Lacroix*, W Koch*, D Ritter*, AC Gutleb*, ST Larsen*, T Loret*, F Zanetti, S Constant*, S Chortarea*, B Rothen-Rutishauser*, PS Hiemstra*, E Frejafon*, P Hubert*, L Gribaldo*, P Kearns*, JM Aublant*, S Diabaté*, C Weiss*, A de Groot*, I Kooter*
    * This author is not affiliated with PMI.

    Applied In Vitro Toxicology

    Vol. 4, No. 2

    DOI : 10.1089/aivt.2017.0034

  • Peer-Reviewed Publication

    July 17, 2018

    Platform 2

    In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells

    C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.07.025

  • Clinical Study

    May 4, 2015

    A Multi-center, Multi-region Smoking Cessation Study to Understand the Biological and Functional Changes Related to Smoking Cessation in Healthy Smokers Who Are Continuously Abstinent From Smoking for One Year

    PMI

  • Clinical Study

    January 13, 2017

    Platform 1

    An Observational Cohort Study in Japan to Assess the Patterns of Product Use and Changes in Health Outcomes Associated With the Use of HeatSticks With the Tobacco Heating System

    PMI

  • Clinical Study

    December 22, 2008

    A Controlled, Randomised, Open-Label, 3-Arm Parallel Single-Centre Confinement Study to Investigate Exposure to Selected Smoke Constituents in Smokers Switching From Conventional Cigarettes to SMAR Cigarettes for 5 Days

    PMI

  • Clinical Study

    November 10, 2010

    A European, Multi-centre Study to Determine the Exposure of Adult Smokers and Non-smokers to Cigarette Smoke Constituents

    PMI

  • Clinical Study

    November 7, 2011

    A Single-centre, Dose Titration Study in Healthy Volunteers (Smokers and Non-smokers) to Evaluate the Capacity of 2-cyanoethylmercapturic Acid (CEMA) to Detect Low Level of Cigarette Smoking Exposure

    PMI

  • Clinical Study

    January 31, 2013

    A Biomarker Study to Compare Gene and Protein Expression Profiles in Four Separate Groups of Subjects Including COPD Cases (GOLD Stage 1-2 and Current Smokers With a ≥ 10 Pack Year Smoking History) and Three Control Groups of Matched Non-smoking Subjects (Never Smoked), Ex-smokers and Current Smokers, to Identify Novel Biomarkers, to Assess Standard Biomarkers of Inflammation and to Compare Inflammatory Cell Responses and Selected Markers of Inflammation in Blood, Induced Sputum and Nasal Samples.

    PMI

  • Clinical Study

    January 31, 2013

    Platform 1

    A Single-center, Open-label, Randomized, Controlled, Crossover Study to Explore the Nicotine Pharmacokinetic Profile and Safety of Tobacco Heating System (THS) 2.1 Compared to Conventional Cigarettes Following Single and ad Libitum Use in Smoking, But Otherwise Healthy Subjects.

    PMI

  • Clinical Study

    January 31, 2013

    Platform 1

    A Single-center, Open-label, Randomized, Controlled, 2-arm Parallel Group Study to Evaluate the Exposure to Selected Smoke Constituents in Smoking, But Otherwise Healthy Subjects Switching From Conventional Cigarettes to the Tobacco Heating System (THS) 2.1

    PMI

  • Clinical Study

    April 4, 2014

    A Multi-center Study to Determine the Levels of Biomarkers of Potential Harm and Biomarkers of Exposure to Cigarette Smoke in Asian Adult Smokers and Non-smokers

    PMI

  • Clinical Study

    March 22, 2017

    A 2-arm, Open Label, Prefatory Study to Explore Changes in Nasal Mucociliary Clearance Between Smokers and Never Smokers and to Standardize Nasal Scraping Procedure

    PMI

  • Clinical Study

    December 7, 2017

    Platform 1

    A 6-month Randomized, Controlled, Open-label, 2-arm Parallel Group, Multicenter Study to Evaluate the Effect of Switching From Cigarette Smoking to the Use of Platform 1 in Smokers With Generalized Chronic Periodontitis on the Response to Mechanical Periodontal Treatment and Oral Health Status.

    PMI

  • Clinical Study

    December 12, 2017

    Platform 3

    A Single-center, Open-label, Randomized, Crossover Study to Investigate the Nicotine Pharmacokinetic Profile, Pharmacodynamics, Safety and Tolerability of Four P3P Variants in Smoking Healthy Adult Subjects

    PMI

  • Clinical Study

    December 20, 2017

    Platform 4

    A Single-center, Open-label, Concentration-ranging Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of the P4M3 Variants

    PMI

  • Clinical Study

    May 16, 2018

    Platform 1

    Cross Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in Italy (2018-2020)

    PMI

  • Clinical Study

    May 16, 2018

    Platform 1

    Cross-Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in Germany (2018-2020)

    PMI

  • Clinical Study

    May 16, 2018

    Platform 1

    Cross Sectional Survey on the Use of Tobacco Products in the General Population and in Users of Platform 1 in London (2018-2020)

    PMI

  • Clinical Study

    June 11, 2018

    Platform 1

    Assessment of passive environmental aerosol exposure through the Tobacco Heating System (THS) in a restaurant setting where THS use, but not cigarette smoking, is allowed

    PMI

  • Peer-Reviewed Publication

    June 30, 2018

    Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

    F Lucci, ND Castro*, AA Rostami*, M J Oldham*, J Hoeng, YB Pithawalla*, A Kuczaj
    * This author is not affiliated with PMI.

    Journal of Aerosol Science

    Volume 123, September 2018, Pages 141-160

    DOI : 10.1016/j.jaerosci.2018.06.015

  • Peer-Reviewed Publication

    July 9, 2018

    Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures

    S Steiner, P Diana, E Dossin, P Guy, G Vuillaume, A Kondylis, S Majeed, S Frentzel, J Hoeng

    Toxicology in Vitro

    DOI : 10.1016/j.tiv.2018.06.024

  • Peer-Reviewed Publication

    July 2, 2018

    Platform 1

    Role of testing standards in smoke-free product assessments

    M Belushkin, M Esposito, G Jaccard, C Jeannet, A Korneliou, D Tafin Djoko

    Regulatory Toxicology and Pharmacology

    Volume 98, October 2018, Pages 1-8

    DOI : 10.1016/j.yrtph.2018.06.021

  • Peer-Reviewed Publication

    June 12, 2011

    Modeling Early Initiation Processes in Smoking-Induced Lung Adenocarcinomas

    G Vuillaume, T Mueller, M Talikka, Y Cheng, G Diserens, M Peitsch, J Hoeng, F Tobin*
    * This author is not affiliated with PMI.

    Proceedings of the 8th International Workshop on Computation Systems Biology

  • Peer-Reviewed Publication

    January 1, 2017

    Menthol Cigarettes, Time to First Cigarette, and Smoking Cessation

    EB Sanders, R Weitkunat, R Dempsey

    Beiträge zur Tabakforschung International

    Volume 27, No. 5

    DOI : 10.1515/cttr-2017-0003

  • Peer-Reviewed Publication

    March 1, 2017

    The Adverse Outcome Pathway for Oxidative Stress-Mediated EGFR Activation Leading to Decreased Lung Function

    K Luettich, M Talikka, FJ Lowe*, LE Haswell, J Park*, M Gaca*, J Hoeng
    * This author is not affiliated with PMI.

    Applied In Vitro Toxicology

    Vol. 3, No. 1

    DOI : 10.1089/aivt.2016.0032

  • Peer-Reviewed Publication

    March 1, 2017

    Development of an adverse outcome pathway for the onset of hypertension by oxidative stress-mediated perturbation of endothelial nitric oxide bioavailability

    FJ Lowe*, K Luettich, M Talikka, V Hoang*, LE Haswell, J Hoeng, M Gaca*
    * This author is not affiliated with PMI.

    Applied In Vitro Toxicology

    Vol. 3, No. 1

    DOI : 10.1089/aivt.2016.0031

  • Peer-Reviewed Publication

    March 31, 2017

    Systems toxicology: Real World Applications and Opportunities

    T Hartung*, RE FitzGerald*, P Jennings*, Gary R. Mirams*, M Peitsch, A Rostami-Hodjegan*, I Shah*, MF Wilks*, SJ Sturla*
    * This author is not affiliated with PMI.

    Chemical Research in Toxicology

    30(4): 870-882

    DOI : 10.1021/acs.chemrestox.7b00003

  • Peer-Reviewed Publication

    September 5, 2017

    Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.

    S Boue, T Exner*, D Ghosh, V Belcastro, J Dokler*, D Page, A Boda, F Bonjour, B Hardy*, P Vanscheeuwijck, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    F1000Research

    6:12

    DOI : 10.12688/f1000research.10493.1

  • Peer-Reviewed Publication

    March 19, 2016

    Evaluation of oscillation-free fluid-porous interface treatments for segregated finite volume flow solvers

    M Stanic*, M Nordlund, EM Frederix*, A Kuczaj, BJ Geurts*
    * This author is not affiliated with PMI.

    Computers & Fluids

    Volume 131, Pages 169-179

    DOI : 10.1016/j.compfluid.2016.03.019

  • Peer-Reviewed Publication

    June 30, 2018

    Advancing Risk Assessment through the Application of Systems Toxicology.

    JM Sauer*, A Kleensang*, M Peitsch, AW Hayes
    * This author is not affiliated with PMI.

    Toxicological Research

    32(1): 5–8.

    DOI : 10.5487/TR.2016.32.1.005

  • Peer-Reviewed Publication

    January 22, 2016

    Heterocyclic aromatic amines and their contribution to the bacterial mutagenicity of the particulate phase of cigarette smoke.

    E Roemer, T Meisgen, J Diekmann, LL Conroy, R Stabbert

    Toxicology Letters

    Toxicol Lett 243: 40-47.

    DOI : 10.1016/j.toxlet.2015.12.008

  • Peer-Reviewed Publication

    May 15, 2016

    Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

    U Marx*, TB Andersson *, A Bahinski*, M Beilmann*, S Beken*, FR Cassee*, M Cirit*, M Daneshian *, S Fitzpatrick*, O Frey *, C Gaertner*, C Giese *, L Griffith *, T Hartung*, MB Heringa*, J Hoeng, WH de Jong *, H Kojima*, J Kuehnl*, M Leist*, A Luch *, I Maschmeyer*, D Sakharov*, AJAM Sips*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, T Tralau*, S Tsyb*, A van de Stolpe *, R Vandebriel*, P Vulto*, J Wang*, J Wiest*, M Rodenburg*, A Roth*
    * This author is not affiliated with PMI.

    Altex

    Altex 33(3): 272-321.

    DOI : 10.14573/altex.1603161

  • Peer-Reviewed Publication

    August 20, 2016

    Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)

    J Fluck*, S Madan*, S Ansari, AT Kodamullil*, R Karki*, M Rastegar-Mojarad*, NL Catlett*, WS Hayes, J Szostak, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    Database

    Database, Volume 2016

    DOI : 10.1093/database/baw113

  • Peer-Reviewed Publication

    December 31, 2016

    Improved knowledge acquisition and creation of structured knowledge for systems toxicology.

    S Ansari, J Szostak, M Talikka, J Fluck*, J Hoeng
    * This author is not affiliated with PMI.

    International Journal On Advances in Life Sciences

    Int J Adv Life Sci 8: 309-319.

  • Peer-Reviewed Publication

    January 5, 2016

    Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.

    S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
    * This author is not affiliated with PMI.

    Scientific Data

    Sci Data 3: 150077.

    DOI : 10.1038/sdata.2015.77

  • Presentation

    June 9, 2018

    Platform 1

    Thermal decomposition behavior of the tobacco material used in a heated tobacco product

    M Nordlund

    Pyro2018

  • Poster

    June 8, 2018

    Platform 1

    Non-targeted screening using GC×GC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product

    M Almstetter, A Knorr, M Rhouma, E Martin, A Castellon, P Pospisil, M Bentley

    66th ASMS Conference on Mass Spectrometry and Allied Topics

  • Poster

    June 8, 2018

    Platform 1

    Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry

    A Knorr, E Martin, M Almstetter, A Castellon, P Pospisil, M Bentley

    66th ASMS Conference on Mass Spectrometry and Allied Topics

  • Poster

    June 8, 2018

    Increasing confidence for compound identification by fragmentation database and in silico fragmentation comparison with LC-HRAM-MS-based non-targeted screening of complex matrices

    C Buchholz, D Arndt, C Wachsmuth, M Bentley

    66th ASMS Conference on Mass Spectrometry and Allied Topics

  • Peer-Reviewed Publication

    June 20, 2018

    Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

    AJ Clippinger*, D Allen*, HP Behrsing *, KA BéruBé*, MB Bolger*, W Casey*, M DeLorme*, M Gaca*, SC Gehen*, K Glover*, P Hayden*, P Hinderliter*, JA Hotchkiss*, A Iskandar, B Keyser*, K Luettich, L Ma-Hock*, A Maione*, P Makena*, J Melbourne*, L Milchak*, SP Ng*, A Paini*, K Page*, G Patlewicz*, P Prieto*, H Raabe*, EN Reinke*, C Roper*, J Rose*, M Sharma*, W Spoo*, PS Thorne*, DM Wilson*, AM Jarabek*
    * This author is not affiliated with PMI.

    Toxicology in Vitro

    Volume 52, Pages 131–145

    DOI : 10.1016/j.tiv.2018.06.009

  • Peer-Reviewed Publication

    June 9, 2018

    Modeling the impact of changes in tobacco use on individual disease risks

    S Djurdjevic, Z Sponsiello Wang, PN Lee*, JS Fry*, R Weitkunat, F Lüdicke, G Baker
    * This author is not affiliated with PMI.

    Regulatory Toxicology and Pharmacology

    Volume 97, Pages 88-97

    DOI : 10.1016/j.yrtph.2018.06.001

  • Peer-Reviewed Publication

    June 22, 2018

    Platform 4

    Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

    TR Sosnowski*, K Jabłczyńska*, M Odziomek*, W Schlage, A Kuczaj
    * This author is not affiliated with PMI.

    Inhalation Toxicology

    DOI : 10.1080/08958378.2018.1478916

  • Peer-Reviewed Publication

    June 16, 2018

    Platform 1

    Investigation and comparison of the transfer of TSNA from tobacco to cigarette mainstream smoke and to the aerosol of a heated tobacco product, THS2.2

    G Jaccard, A Kondylis, I Gunduz, J Pijnenburg, M Belushkin

    Regulatory Toxicology and Pharmacology

    Volume 97, Pages 103–109

    DOI : 10.1016/j.yrtph.2018.06.011

  • Peer-Reviewed Publication

    January 18, 2015

    Synergy, suppression and immorality: forward differences of the entropy function.

    J Whittaker*, F Martin, Y Xiang
    * This author is not affiliated with PMI.

    arXiv

    1501.04368

  • Peer-Reviewed Publication

    June 17, 2015

    Construction of biological networks from unstructured information based on a semi-automated curation workflow.

    J Szostak, S Ansari, S Madan*, J Fluck*, M Talikka, A Iskandar, H De Leon, M Hofmann-Apitius*, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    Database

    DOI : 10.1093/database/bav057

  • Peer-Reviewed Publication

    March 23, 2015

    Systems Toxicology: The Future of Risk Assessment.

    JM Sauer*, T Hartung*, M Leist*, TB Knudsen*, J Hoeng, AW Hayes
    * This author is not affiliated with PMI.

     International Journal of Toxicology

    34(4):346-8.

    DOI : 10.1177/1091581815576551

  • Peer-Reviewed Publication

    May 1, 2015

    An Improved GC-MS Method for Cigarette Smoke Characterization Using a Novel Cold Trap, Dual Column, and Cryofocusing System

    M Rotach, E G R Rouget, J R Crudo

    LC GC Europe

    Volume 28, Issue 5, pg 258–264

  • Peer-Reviewed Publication

    May 19, 2015

    Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas–vapor phase of cigarette smoke.

    E Roemer, V Zenzen, LL Conroy, K Luedemann, R Dempsey, C Schunck*, E TrellesSticken*
    * This author is not affiliated with PMI.

    Toxicology Mechanisms and Methods

    Volume 25, 2015 - Issue 4

    DOI : 10.3109/15376516.2015.1037413

  • Peer-Reviewed Publication

    July 2, 2015

    Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion.

    C Poussin, A Laurent, M Peitsch, J Hoeng, H De Leon

    Toxicological Sciences

    147(2):370-85.

    DOI : 10.1093/toxsci/kfv137

  • Peer-Reviewed Publication

    November 3, 2014

    Differences in cadmium transfer from tobacco to cigarette smoke, compared to arsenic or lead

    JJ Piadé, G Jaccard, C Dolka, M Belushkin, S Wajrock

    Toxicology Reports

    Volume 2, 2015, Pages 12-26

    DOI : 10.1016/j.toxrep.2014.11.005

  • Peer-Reviewed Publication

    May 26, 2015

    Median estimation of chemical constituents for sampling on two occasions under a log-normal model.

    A Kondylis

    Biometrical Journal.

    57(5): 914–929.

    DOI : 10.1002/bimj.201400095

  • Peer-Reviewed Publication

    August 13, 2015

    Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.

    U Kogel, I Gonzalez-Suarez, Y Xiang, E Dossin, P Guy, C Mathis, D Marescotti, D Goedertier, F Martin, M Peitsch, J Hoeng

    Toxicology in Vitro

    Volume 29, Issue 8, Pages 2102-2115

    DOI : 10.1016/j.tiv.2015.08.004

  • Peer-Reviewed Publication

    February 15, 2015

    Where are we at regarding species translation? A review of the sbv IMPROVER challenge.

    J Hoeng, M Peitsch, P Meyer*, I Jurisica
    * This author is not affiliated with PMI.

    Bioinformatics

     Volume 31, Issue 4, Pages 451–452,

  • Peer-Reviewed Publication

    April 30, 2015

    Extension of the compressible PISO algorithm to single-species aerosol formation and transport

    EM Frederix*, M Stanic*, A Kuczaj, M Nordlund, BJ Geurts*
    * This author is not affiliated with PMI.

    International Journal of Multiphase Flow

    Volume 74, September 2015, Pages 184-194

    DOI : 10.1016/j.ijmultiphaseflow.2015.04.015

  • Peer-Reviewed Publication

    June 25, 2015

    Considerations for comparative tobacco product assessments based on smoke constituent yields

    M Belushkin, G Jaccard, A Kondylis

    Regulatory Toxicology and Pharmacology

     Volume 73, Issue 1, October 2015, Pages 105-113

    DOI : 10.1016/j.yrtph.2015.06.017

  • Peer-Reviewed Publication

    February 7, 2014

    Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons

    BSP Schreiner*, R Lehmann*, U Thiel*, PM Ziemba*, LR Beltrán*, MA Sherkheli*, P Jeanbourquin, A Hugi, M Werner*, G Gisselmann*, H Hatt*
    * This author is not affiliated with PMI.

    European Journal of Pharmacology

    Volume 728, 5 April 2014, Pages 48-58

    DOI : 10.1016/j.ejphar.2014.01.060

  • Peer-Reviewed Publication

    June 13, 2014

    A decade of Systems Biology: where are we and where are we going to?

    M Peitsch, D de Graaf*
    * This author is not affiliated with PMI.

    Drug Discovery Today

    DOI : 10.1016/j.drudis.2013.06.002

  • Peer-Reviewed Publication

    January 1, 2013

    A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.

    JW Westra*, W Schlage, A Hengstermann*, S Gebel*, C Mathis, TM Thomson, B Wong*, V Hoang*, E Veljkovic, M Peck, RB Lichtner, D Weisensee, M Talikka, R Deehan*, J Hoeng, M Peitsch
    * This author is not affiliated with PMI.

    Bioinformatics and Biology Insights

    Volume 7

    DOI : 10.4137/BBI.S11509

  • Peer-Reviewed Publication

    November 11, 2013

    Computer-assisted structure identification (CASI)--an automated platform for high-throughput identification of small molecules by two-dimensional gas chromatography coupled to mass spectrometry.

    A Knorr, A Monge, M Stueber, A Stratmann, D Arndt, E Martin, P Pospisil

    Analytical chemistry.

    85(23): 11216-11224.

    DOI : 10.1021/ac4011952

  • Peer-Reviewed Publication

    December 5, 2013

    Assessing smoking behaviour and tobacco smoke exposure: definitions and methods

    E Gregg*, T Bachmann, R Bito*, X Cahours*, M McEwan*, P Nelson*, K Prasad*, G Scherer*, M Stiles*
    * This author is not affiliated with PMI.

    Beiträge zur Tabakforschung International

    Volume 25, No. 8

  • Peer-Reviewed Publication

    August 15, 2013

    Menthol addition to cigarettes using breakable capsules in the filter. Impact on the mainstream smoke yields of the Health Canada list constituents.

    C Dolka, JJ Piadé, M Belushkin, G Jaccard

    Chemical Research in Toxicology

    DOI : 10.1021/tx400146x

  • Peer-Reviewed Publication

    January 12, 2012

    Does the use of ingredients added to tobacco increase cigarette addictiveness?: a detailed analysis.

    EB Sanders, R Weitkunat, A Utan, R Dempsey

    Inhalation Toxicology

    DOI : 10.3109/08958378.2012.663006

  • Peer-Reviewed Publication

    February 6, 2012

    Headspace Volumetric Karl Fischer Titration for the Determination of Water Content in Finished Tobacco Products

    N Aydin, F Chardonnens, M Rotach

    Beiträge zur Tabakforschung International

    Volume 25, No. 1

    DOI : 10.2478/cttr-2013-0914

  • Peer-Reviewed Publication

    February 14, 2011

    Limitations of cigarette machine smoking regimens.

    E Roemer, RA Carchman*
    * This author is not affiliated with PMI.

    Toxicology Letters

    Volume 203, Issue 1

    DOI : 10.1016/j.toxlet.2011.02.014

  • Peer-Reviewed Publication

    July 10, 2011

    Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study.

    D Lindner, S Smith*, C Martin Leroy, A R Tricker
    * This author is not affiliated with PMI.

    Cancer Epidemiology, Biomarkers & Prevention

    DOI : 10.1158/1055-9965.EPI-10-1186

  • Peer-Reviewed Publication

    December 13, 2010

    Cigarette smoke enhances abdominal aortic aneurysm formation in angiotensin II-treated apolipoprotein E-deficient mice.

    K Stolle, A Berges, M Lietz, S Lebrun, T Wallerath

    Toxicology Letters

    Volume 199, Issue 3

    DOI : 10.1016/j.toxlet.2010.10.005

  • Peer-Reviewed Publication

    December 30, 2014

    The Addition of Cocoa, Glycerol, and Saccharose to the Tobacco of Cigarettes: Implications for Smoke Chemistry, In Vitro Cytotoxicity, Mutagenicity and Further Endpoints

    E Roemer, S Wittke, E TrellesSticken*, JJ Piade*, T Bonk, MK Schorp*
    * This author is not affiliated with PMI.

    The Journal of BTFI GmbH

    Volume 24: Issue 3

    DOI : 10.2478/cttr-2013-0890

  • Peer-Reviewed Publication

    June 10, 2009

    Biotransformation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Lung Tissue from Mouse, Rat, Hamster, and Man

    E Richter*, J Engl*, S Friesenegger*, A R Tricker
    * This author is not affiliated with PMI.

    Chemical Research in Toxicology

    22(6):1008-17

    DOI : 10.1021/tx800461d

  • Peer-Reviewed Publication

    December 30, 2014

    A Modelling Approach to Develop Machine Smoking Protocols Reflecting Human Puffing Behaviour for Conventional Cigarettes

    HJ Urban, W Gomm, MK Schorp*
    * This author is not affiliated with PMI.

    The Journal of BTFI GmbH

    DOI : 10.2478/cttr-2013-0844

  • Peer-Reviewed Publication

    January 10, 2009

    Systematic review of the relation between smokeless tobacco and cancer of the pancreas in Europe and North America

    Z Sponsiello Wang, R Weitkunat, PN Lee*
    * This author is not affiliated with PMI.

    BMC Cancer

    8(1):356

    DOI : 10.1186/1471-2407-8-356

  • Infoposter

    June 15, 2018

    Platform 1

    Product experience and risk perceptions in Platform 1 users: a cross-sectional survey in Japan

    P Langer, Z Sponsiello Wang, L Prieto, M Dobrynina, D Skiada, N Camille, R Weitkunat, F Lüdicke

    GFN 2018

  • Infoposter

    June 15, 2018

    Potential Predictors of Intended Use of a Novel Heat-Not-Burn Tobacco Product

    F Beacher, PP Magnani, A Ramazzotti, S Colman*, F Lüdicke, R Weitkunat, G Kallischnigg, B Zwisele*
    * This author is not affiliated with PMI.

    GFN 2018

  • Infoposter

    June 15, 2018

    A Multi-Center, Multi-Regional, Study on Biological and Functional Changes in Healthy Adult Smokers during One Year of Continuous Smoking Abstinence

    C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke

    GFN 2018

  • Infoposter

    June 15, 2018

    Modeling the Population Health Impact of introducing a Reduced Risk Product into the Japan market

    S Djurdjevic, G Baker, T Iida, E Konishi, F Lüdicke

    GFN 2018

  • Infoposter

    June 15, 2018

    Evaluation of biological and functional changes in healthy smokers after switching from cigarettes to Tobacco Heating System (THS) 2.2 for 6 months

    S Ansari, N Lama, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke

    GFN 2018

  • Infoposter

    June 15, 2018

    Assessing consumer responses to reduced risk products: experience at Philip Morris International in developing fit-for-purpose self-report instruments

    C Chrea, E Spies, E Afolalu, N Mainy, S Gallot, P Binggeli, E Clerc, R Weitkunat, T Salzberger, S Cano, C Acquadro*, B Arnould*, V Brunel*, J Lambert*, C Marcuccilli*, L Abetz-Webb*, Jed E Rose PhD*, K Fagerström*
    * This author is not affiliated with PMI.

    GFN 2018

  • Presentation

    June 15, 2018

    Platform 1

    Changes in Biological and Functional Markers after Six Months, in Three Populations: THS 2.2 (IQOS) Users, Continued Smokers, and Smoking Abstinence

    C Haziza

    GFN 2018

  • Peer-Reviewed Publication

    June 8, 2018

    Interrogating the microbiome: experimental and computational considerations in support of study reproducibility

    C Poussin, N Sierro, S Boue, JND Battey, E Scotti, V Belcastro, M Peitsch, NV Ivanov, J Hoeng

    Drug Discovery Today

    DOI : 10.1016/j.drudis.2018.06.005

  • Poster

    June 11, 2018

    Platform 1

    Changes in Clinical Risk Endpoints Linked to Cardiovascular and Other Smoking-Related Diseases after Switching from Cigarettes to the Tobacco Heating System (THS) 2.2 for Six Months

    C Haziza, S Ansari, N Lama, M Bosilkovska, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, F Lüdicke

    ISA 2018

  • Poster

    June 11, 2018

    Platform 1

    Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking

    G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck

    ISA 2018

  • Presentation

    June 9, 2018

    Platform 1

    Cardiovascular Effects of the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking

    P Picavet

    1st Scientific Summit on Tobacco Harm Reduction: Novel products, Research & Policy

  • Methods and Protocols

    June 7, 2018

    Platform 1

    Analysis of water, nicotine, triacetin in Platform 1 aerosol

    PMI

  • Methods and Protocols

    June 7, 2018

    Platform 1

    Analysis of volatiles and semi-volatiles in Platform 1 Aerosol

    PMI

  • Peer-Reviewed Publication

    March 7, 2018

    Physiological and biological characterization of smokers with and without COPD.

    N Chaudhary, K Luettich, M Peck, E Pierri, Loyse Felber Medlin , G Vuillaume, P Leroy, J Hoeng, M Peitsch

    F1000Research

    Version 2

    DOI : 10.12688/f1000research.11698.2

  • Report

    June 6, 2018

    Smoke-Free Products – The Scientific Update June 2018 Issue 05

    PMI

  • Book Chapter

    May 23, 2018

    Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

    G Lo Sasso, W Schlage, B Phillips, M Peitsch, J Hoeng

    Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy

    DOI : 10.5772/intechopen.69569

  • Poster

    May 25, 2018

    Enabling Systems Toxicology Assessment Studies with State-of-the-Art Biospecimen Data Management Systems

    E Dargaud, S Ansari

    ISBER 2018

  • Peer-Reviewed Publication

    May 10, 2018

    SolCyc: a database hub at the Sol Genomics Network (SGN) for the manual curation of metabolic networks in Solanum and Nicotiana specific databases

    H Foerster*, A Bombarely*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
    * This author is not affiliated with PMI.

    Database: The Journal of Biological Databases and Curation

    2018

    DOI : 10.1093/database/bay035

  • Presentation

    April 27, 2018

    Platform 1

    Clinical assessment of products aiming at reducing the risk of use compared with continued cigarette smoking

    A Donelli

  • Poster

    May 9, 2018

    Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology

    C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
    * This author is not affiliated with PMI.

    EAS 2018

  • Poster

    May 9, 2018

    Platform 1

    Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study

    B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
    * This author is not affiliated with PMI.

    EAS 2018

  • Poster

    May 5, 2018

    Platform 4

    Establishing the baseline effects of non-flavoured e-liquids and flavour compounds in the in vitro micronucleus assay

    D Smart, P Vanscheeuwijck, D McHugh, E Nallet, FR Helbling

    GTA 2018

  • Poster

    May 5, 2018

    Mode-of-action analysis of a positive in vitro micronucleus finding in CHO-WBL cells

    D McHugh, P Vanscheeuwijck, FR Helbling, D Smart

    GTA 2018

  • Presentation

    May 5, 2018

    Nicotine-Containing E-Vapor Products

    Mode-of-action analysis of genotoxicity detected by the in vitro micronucleus assay: two industry case studies

    D Smart

    GTA 2018

  • Presentation

    May 21, 2018

    Platform 1

    Molecular biomarkers elucidate the role of inflammation and oxidative stress in smoking-related diseases

    NV Ivanov

    11th International Congress on Autoimmunity

  • Peer-Reviewed Publication

    April 19, 2018

    Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B2

    A van der Plas, S Pouly, G de La Bourdonnaye, W Teck Ng, G Baker, F Lüdicke

    Toxicology Reports

    DOI : 10.1016/j.toxrep.2018.04.005

  • Peer-Reviewed Publication

    May 7, 2018

    Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science

    M Peitsch, R Polosa*, C Proctor*, T Hassler*, M Gaca*, E Hill*, J Hoeng, AW Hayes
    * This author is not affiliated with PMI.

    Toxicology Research and Application

    Volume 2: 1–12

    DOI : 10.1177/2397847318773701

  • Presentation

    April 11, 2018

    A review of analytical approaches to assess transitions in patterns of tobacco product use in the population

    E Afolalu

    Coresta SG PUB

  • Peer-Reviewed Publication

    May 16, 2018

    Platform 1

    Modeling the Population Health Impact of Introducing a Modified Risk Tobacco Product into the U.S. Market

    S Djurdjevic, PN Lee*, R Weitkunat, Z Sponsiello Wang, F Lüdicke, G Baker
    * This author is not affiliated with PMI.

    Healthcare

    DOI : 10.3390/healthcare6020047

  • Report

    May 9, 2016

    Appendix 2: Independent Expert Risk Benefit Assessment

    R Bass*
    * This author is not affiliated with PMI.

  • Report

    May 27, 2016

    Appendix 1: Expert Report of Prof. Dr. Valerio Cozzani

    V Cozzani*
    * This author is not affiliated with PMI.

  • Report

    May 9, 2018

    Platform 1

    Analysis of Polylactic acid filters of Marlboro Heatsticks: Response to the article entitled “iQOS: evidence of pyrolysis and release of a toxicant from plastic” by Davis B. et al., 2018

    A Glabasnia, P Guy, C Goujon-Ginglinger, S Maeder

  • Peer-Reviewed Publication

    April 11, 2018

    Platform 2

    A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

    B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
    * This author is not affiliated with PMI.

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.04.015

  • Peer-Reviewed Publication

    December 14, 2017

    Platform 1

    Pre-market studies from five countries in Asia and Europe to measure the adoption of the tobacco heating system (THS) in smokers

    S Roulet, N Mainy, C Chrea, PP Magnani, R Weitkunat, G Kallischnigg, A Ramazzotti

    Tobacco Science & Technology

    Vol:50 ,13:86-96

    DOI : 10.16135/j.issn1002-0861.2017.0564

  • Peer-Reviewed Publication

    December 15, 2017

    Perceived risks associated with the use of tobacco and nicotine-containing products: Findings from qualitative research

    T Salzberger, C Chrea, S Cano, M Martin, M Atkison*, G Emilien, N Mainy, A Ramazzotti, R Weitkunat, F Lüdicke
    * This author is not affiliated with PMI.

    Tobacco Science & Technology

    2017 ,Vol:50 ,13:32-42

    DOI : 10.16135/j.issn1002-0861.2017.0562

  • Peer-Reviewed Publication

    July 10, 2017

    Nicotine-Containing E-Vapor Products

    In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use.

    HP Behrsing *, R Devlin*, R Tice*, S Fitzpatrick*, H Raabe*, E Hill*, K Pinkerton*, G Oberdörster*, C Wright*, R Wieczorek*, M Aufderheide*, S Steiner, T Krebs*, B Asgharian*, R Corley*, M J Oldham*, J Adamson*, X Li*, I Rahman*, S Grego*, PH Chu*, S McCullough*, R Curren*
    * This author is not affiliated with PMI.

    ATLA

    45(3): 117-158.

  • Peer-Reviewed Publication

    October 18, 2017

    Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways

    EM Frederix*, A Kuczaj, M Nordlund, M Belka*, F Lizal*, J Jedelsky*, J Elcner*, M Jicha*, BJ Geurts*
    * This author is not affiliated with PMI.

    Journal of Aerosol Science

    DOI : 10.1016/j.jaerosci.2017.10.007

  • Peer-Reviewed Publication

    March 13, 2018

    Platform 2

    A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment

    B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.02.058

  • Poster

    March 16, 2018

    Four-Week Continuous Nicotine Treatment of Immortalized Bronchial Epithelial Cells Does Not Contribute to Tumorigenesis

    M Van der Toorn, K Baumer, D Peric, D Bornand, R Dulize, E Guedj, A Sewer, D Marescotti, K Luettich, NV Ivanov, M Peitsch, J Hoeng

    SOT 2018

  • Poster

    March 16, 2018

    Platform 1

    Characterization of clones derived from human bronchial epithelial cells after long-term treatment with TPM from reference cigarettes versus THS 2.2

    M Van der Toorn, M Sgandurra, D Marescotti, M Peitsch, J Hoeng, K Luettich

    SOT 2018

  • Poster

    March 16, 2018

    Platform 4

    Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells

    D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng

    SOT 2018

  • Poster

    March 12, 2018

    Microbiome analysis – a review of current recommendations and utilization of a proven crowdsourcing solution to benchmark methods.

    JND Battey, S Boue, C Poussin, N Sierro, E Scotti, V Belcastro, A Petrelis, G Lo Sasso, RM Gadaleta, NV Ivanov, J Hoeng

    ABLS 2018

  • Poster

    March 16, 2018

    Human In Vitro Models for Respiratory Toxicology: Evaluation of Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays

    S Frentzel, M Aragon*, J Hoeng, S Ito*, S Ishikawa*, J Budde*, A Maione*, P Hayden*, W Fields*, B Keyser*, LE Haswell, D Azzopardi*, HP Behrsing *
    * This author is not affiliated with PMI.

    SOT 2018

  • Poster

    March 9, 2018

    Platform 1

    Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome

    C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng

    Proteomics in Cell Biology and Disease Mechanisms

  • Peer-Reviewed Publication

    March 7, 2018

    Platform 1

    The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product

    M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich

    Toxicology in Vitro

    DOI : 10.1016/j.tiv.2018.02.019

  • Peer-Reviewed Publication

    March 1, 2018

    Platform 2

    Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment

    A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.02.063

  • Peer-Reviewed Publication

    March 2, 2018

    Platform 2

    Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens

    F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.02.062

  • Methods and Protocols

    March 22, 2017

    Platform 1

    Analysis of nitrobenzene in THS aerosol

    PMI

  • Methods and Protocols

    March 14, 2017

    Platform 1

    Analysis of propylene oxide in THS aerosol

    PMI

  • Methods and Protocols

    March 14, 2017

    Platform 1

    Analysis of ethylene oxide and vinyl chloride in THS aerosol

    PMI

  • Methods and Protocols

    March 14, 2017

    Platform 1

    Analysis of 12 polycyclic aromatic hydrocarbons in THS aerosol

    PMI

  • Methods and Protocols

    March 2, 2017

    Platform 1

    Analysis of aromatic amines in THS aerosol

    PMI

  • Methods and Protocols

    August 17, 2016

    Platform 1

    Procedure for accurately quantify water in mainstream aerosol of THS aerosol using the in situ extraction method

    PMI

  • Poster

    May 2, 2016

    Platform 1

    Lung Inflammation and Toxicological Assessment in A/J Mice in Response to Chronic Exposure to Mainstream Aerosol from Candidate Modified Risk Tobacco Product and Smoke from Conventional Cigarettes

    E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, E Veljkovic, AW Hayes, P Leroy, P Vanscheeuwijck, M Peitsch, J Hoeng

  • Poster

    May 2, 2016

    Platform 1

    Xenobiotic Metabolism Responses of Nasal, Oral and Bronchial Organotypic Epithelial Cultures: A Comparison of Tobacco Heating System Aerosol and Combustible Cigarette Smoke

    A Iskandar, S Majeed, L Ortega Torres, D Kuehn, S Johne, F Martin, Y Xiang, A Sewer, P Leroy, R Dulize, E Guedj, NV Ivanov, C Mathis, AW Hayes, J Hoeng, M Peitsch

    The Toxicologist 

  • Poster

    March 20, 2015

    Sytems toxicological-based assessment of sex-related differences in response to cigarette smoke within an OECD rat inhalation study

    U Kogel, A Sewer, G Vuillaume, S Boue, M Talikka, E T Wong, WS Hayes, P Vanscheeuwijck, J Hoeng, M Peitsch

    SOT 2015

  • Poster

    March 17, 2017

    Modeling controlled deposition of polydisperse aerosol in 3D in-vitro exposure systems

    F Lucci, A Kuczaj

    NC3Rs Workshop

  • Poster

    March 12, 2017

    Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Aerosol System

    Chris Wynne*, A Teichert, P Brossard, Loyse Felber Medlin , Larissa Sandalic, J Ancerewicz, M Franzon, Murray Laugesen, F Lüdicke
    * This author is not affiliated with PMI.

    SRNT 2017

  • Poster

    March 12, 2017

    Nicotine Population Pharmacokinetics in Healthy Adult Smokers

    P Brossard, M Marchand*, N Lama, R Weitkunat, H Merdjan*, F Lüdicke
    * This author is not affiliated with PMI.

    SRNT 2017

  • Poster

    March 12, 2017

    Intention to use the Tobacco Heating System, associated with variants of a potential product brochure

    F Beacher, PP Magnani, A Ramazzotti, R Weitkunat, G Kallischnigg, S Colman*, T Alfieri*
    * This author is not affiliated with PMI.

    SRNT 2017

  • Poster

    February 27, 2018

    Platform 1

    Comparative effect of a candidate modified risk tobacco product aerosol and cigarette smoke on color stability of enamel, dentin and dental composite resins

    F Zanetti, X Zhao, S Majeed, H Malmstrom*, M Peitsch, Y Ren*, J Hoeng
    * This author is not affiliated with PMI.

    SRNT 2018

  • Poster

    February 27, 2018

    Prediction of disease-specific death rates by using forecasts of their key predictive ecological indicators

    S Djurdjevic, A van der Plas, H Brenner*, G Baker, F Lüdicke
    * This author is not affiliated with PMI.

    SRNT 2018

  • Poster

    February 27, 2018

    Platform 1

    Psychometric evaluation of the mCEQ applied to cigarettes and heat-notburn products in the US and Japan

    T Salzberger, S Cano, N Mainy, C Chrea, S Vandyke, C Haziza, R Weitkunat, Jed E Rose PhD*
    * This author is not affiliated with PMI.

    SRNT 2018

  • Poster

    February 26, 2018

    Platform 1

    Methodology for monitoring adverse event reports for potential modified risk tobacco products: experience at Philip Morris International

    J Magnette, N Blanc, M Pietro, L Prieto, F Lüdicke

    SRNT 2018

  • Poster

    February 26, 2018

    Platform 1

    Potential Predictors of Intended Use of a Novel Heat-not-burn Tobacco Product

    F Beacher, PP Magnani, G Kallischnigg, B Zwisele*, S Colman*, F Lüdicke, A Ramazzotti, R Weitkunat
    * This author is not affiliated with PMI.

    SRNT 2018

  • Poster

    February 26, 2018

    Development of a tobacco and nicotine products dependence instrument

    C Chrea, T Salzberger, L Abetz-Webb*, E Afolalu, S Cano, Jed E Rose PhD*, R Weitkunat, K Fagerström*
    * This author is not affiliated with PMI.

    SRNT 2018

  • Poster

    February 26, 2018

    A multi-center multiregional study on biological and functional changes in healthy adult smokers during one year of continuous smoking abstinence

    C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke

    SRNT 2018

  • Poster

    February 26, 2018

    Linguistic validation of the Perceived Risk Instrument (PRI) into French, German, Italian, Japanese, Polish and Russian

    C Acquadro*, A Belay*, A Popielnicki*, N Mainy, R Weitkunat, C Chrea
    * This author is not affiliated with PMI.

    SRNT 2018

  • Peer-Reviewed Publication

    February 16, 2018

    Platform 1

    Determination of eight carbonyl compounds in aerosols trapped in phosphate buffer saline solutions to support in vitro assessment studies

    R Buratto, D Correia, M Parel, M Crenna, M Bilger, A Debrick

    Talanta

    DOI : 10.1016/j.talanta.2018.02.048

  • Peer-Reviewed Publication

    February 13, 2018

    Platform 1

    Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes

    D Malińska*, J Szymanski*, P Patalas-Krawczyk*, B Michalska*, A Wojtala*, M Prill*, M Partyka*, K Drabik*, J Walczak*, A Sewer, S Johne, K Luettich, M Peitsch, J Hoeng, J Duszynski*, J Szczepanowska*, M Van der Toorn, M Wieckowski*
    * This author is not affiliated with PMI.

    Food and Chemical Toxicology

    DOI : 10.1016/j.fct.2018.02.013

  • Poster

    February 9, 2018

    High-content screening-based phenotypic analysis of 3D organotypic bronchial tissues

    D Marescotti, D Bovard, M Morelli, K Luettich, S Frentzel, M Peitsch, J Hoeng

    SLAS 2018

  • Poster

    February 5, 2018

    Transcriptomic and metabolic analyses of 35S:S523DNR tobacco plants

    L Bovet, J Lu*, JND Battey, RS Lewis, S Goepfert, RE Dewey*
    * This author is not affiliated with PMI.

    SwissPLANT 2018

  • Presentation

    January 18, 2018

    Platform 1

    Nicotine biosynthesis pathway: beyond tobacco

    M Kajikawa*, N Sierro, H Kawaguchi*, N Bakaher, NV Ivanov, T Hashimoto*, T Shoji*
    * This author is not affiliated with PMI.

    PAG 2018

  • Peer-Reviewed Publication

    June 14, 2017

    Platform 1

    Systems Biology: Methods and Applications

    B Titz, A Knorr, A Sewer, F Martin, NV Ivanov, M Talikka, I Gonzalez-Suarez, M Peitsch, J Hoeng

    Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

    Pages 434–480

    DOI : 10.1016/B978-0-12-409547-2.12333-9

  • Peer-Reviewed Publication

    February 5, 2018

    Organization of the TC and TE cT-DNA regions in Nicotiana otophora and functional analysis of three diverged TE-6b genes

    K Chen*, F Dorlhac de Borne*, N Sierro, NV Ivanov, M Alouia*, S Koechler*, L Otten*
    * This author is not affiliated with PMI.

    the plant journal

    DOI : 10.1111/tpj.13853

  • Book Chapter

    January 3, 2018

    Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases 1st Edition

    E Veljkovic, W Xia, B Phillips, E T Wong, J Ho, A Oviedo, J Hoeng, M Peitsch

    Academic Press

  • Peer-Reviewed Publication

    December 29, 2017

    Platform 1

    Accuracy of the Smoking Questionnaire

    Z Sponsiello Wang, G de La Bourdonnaye, M David, F Lüdicke, R Weitkunat

    Beiträge zur Tabakforschung International/Contributions to Tobacco Research

    DOI : 10.1515/cttr-2017-0023

  • Peer-Reviewed Publication

    December 29, 2017

    Platform 1

    Determination of Mercury in Aerosol by Inductively Coupled Plasma Mass Spectrometry

    I Hofer, M Gremaud, A Marchese, S Le Bouhellec

    Beiträge zur Tabakforschung International/Contributions to Tobacco Research

    Volume 27, Issue 8, Pages 186–194

    DOI : 10.1515/cttr-2017-0020

  • Report

    December 10, 2017

    Smoke-Free Products – The Scientific Update December 2017 Issue 04

    PMI

  • Report

    November 2, 2017

    Smoke-Free Products – The Scientific Update November 2017 Issue 03

    PMI

  • Peer-Reviewed Publication

    January 9, 2018

    Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

    M Peck, EB Sanders, G Scherer*, F Lüdicke, R Weitkunat
    * This author is not affiliated with PMI.

    Biomarkers

    DOI : 10.1080/1354750X.2017.1419284

  • Peer-Reviewed Publication

    December 28, 2017

    Platform 1

    Innovative methodology based on thermo-denuder principle for the detection of combustion related solid particles or high boiling point droplets: Applications to cigarette and the Tobacco Heating System THS 2.2

    P Pratte, S Cosandey, C Goujon-Ginglinger

    Journal of Aerosol Science

    DOI : 10.1016/j.jaerosci.2017.12.011

  • Peer-Reviewed Publication

    January 2, 2018

    Platform 1

    Effects of cigarette smoking on color stability of dental resin composites.

    X Zhao, F Zanetti, S Majeed, J Pan*, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
    * This author is not affiliated with PMI.

    American Journal of Dentistry.

    30(6):316-322.

  • Peer-Reviewed Publication

    December 13, 2017

    Exploring the microbiome in health and disease: Implications for toxicology

    E Scotti, S Boue, G Lo Sasso, F Zanetti, V Belcastro, C Poussin, N Sierro, JND Battey, A Gimalac, NV Ivanov, J Hoeng

    Toxicology Research and Application

    DOI : 10.1177/2397847317741884

  • Peer-Reviewed Publication

    December 18, 2017

    Platform 1

    Quantifying the risk-reduction potential of new Modified Risk Tobacco Products

    F Martin, G Vuillaume, G Baker, Z Sponsiello Wang, PF Ricci*, F Lüdicke, R Weitkunat
    * This author is not affiliated with PMI.

    Regulatory Toxicology and Pharmacology

    DOI : 10.1016/j.yrtph.2017.12.011

  • Presentation

    December 5, 2017

    Genetic Approaches and Resources for Enabling Compliance to Proposed NNN Standards

    RE Dewey*, RS Lewis, J Lu*, L Bovet, S Goepfert, P Campanoni
    * This author is not affiliated with PMI.

    71st Tobacco Science Research Conference

  • Poster

    December 5, 2017

    Platform 1

    Systems Toxicology meta-analysis: Impact of a candidate Modified-Risk Tobacco Product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures

    A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng

    SWISSTOX 2017- Annual Meeting of the Swiss Society of Toxicology

  • Poster

    November 20, 2017

    Platform 1

    Genetic and Cell Toxicology In Vitro Assessment of Potentially Reduced Risk Products for Smokers

    D McHugh, D Smart, G Cudazzo, P Vanscheeuwijck

    ICEM-ACEM 2017

  • Presentation

    November 20, 2017

    Platform 1

    Pre-clinical and clinical studies in COPD and Cardiovascular areas and the Role of Biomarkers

    JND Battey

    ICEM-ACEM 2017

  • Poster

    September 14, 2017

    Platform 2

    Biomarker of Exposure Reductions Upon Switching for 5 Days From Cigarettes to a Carbon Heated Tobacco Product (CHTP 1.0)

    C Tran, A Donelli, C Haziza, J Ancerewicz, G de La Bourdonnaye, R Weitkunat, F Lüdicke

    EUROTOX 2017

  • Poster

    November 16, 2017

    Platform 1

    Multiomics integration of transcriptomics, proteomics, and lipidomics for toxicological assessment

    A Sewer, B Titz, F Martin, M Peitsch, J Hoeng

    EMBO | EMBL Symposia

  • Peer-Reviewed Publication

    November 9, 2017

    Platform 1

    Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes

    S Maeder, M Peitsch